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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''G protein-activated inward rectifier potassium channel 2''' is a [[protein]] that in humans is encoded by the ''KCNJ6'' [[gene]].<ref name="pmid7796919">{{cite journal | vauthors = Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM | title = Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit | journal = FEBS Lett | volume = 367 | issue = 2 | pages = 193–7 | date = August 1995 | pmid = 7796919 | pmc =  | doi = 10.1016/0014-5793(95)00498-X }}</ref><ref name="pmid16382105">{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 509–26 | date = December 2005 | pmid = 16382105 | pmc =  | doi = 10.1124/pr.57.4.11 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3763| accessdate = }}</ref> Mutation in KCNJ6 gene has been proposed to be the cause of [[Keppen-Lubinsky Syndrome]] (KPLBS). <ref>{{Cite journal|last=Masotti|first=Andrea|last2=Uva|first2=Paolo|last3=Davis-Keppen|first3=Laura|last4=Basel-Vanagaite|first4=Lina|last5=Cohen|first5=Lior|last6=Pisaneschi|first6=Elisa|last7=Celluzzi|first7=Antonella|last8=Bencivenga|first8=Paola|last9=Fang|first9=Mingyan|date=2015-02-05|title=Keppen-Lubinsky Syndrome Is Caused by Mutations in the Inwardly Rectifying K+ Channel Encoded by KCNJ6|url=http://www.cell.com/ajhg/abstract/S0002-9297(14)00517-5|journal=The American Journal of Human Genetics|language=English|volume=96|issue=2|pages=295–300|doi=10.1016/j.ajhg.2014.12.011|issn=0002-9297|pmid=25620207|pmc=4320262}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 6
| HGNCid = 6267
| Symbol = KCNJ6
| AltSymbols =; BIR1; GIRK2; KATP2; KCNJ7; KIR3.2; MGC126596; hiGIRK2
| OMIM = 600877
| ECnumber = 
| Homologene = 1688
| MGIid = 104781
| GeneAtlas_image1 = PBB_GE_KCNJ6_210454_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0015467 |text = G-protein activated inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3763
    | Hs_Ensembl = ENSG00000157542
    | Hs_RefseqProtein = NP_002231
    | Hs_RefseqmRNA = NM_002240
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 37918656
    | Hs_GenLoc_end = 38023562
    | Hs_Uniprot = P48051
    | Mm_EntrezGene = 16522
    | Mm_Ensembl = ENSMUSG00000043301
    | Mm_RefseqmRNA = NM_001025584
    | Mm_RefseqProtein = NP_001020755
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 94869867
    | Mm_GenLoc_end = 95106172
    | Mm_Uniprot = Q0VB45
  }}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 6''', also known as '''KCNJ6''' or '''K<sub>ir</sub>3.2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3763| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by [[G protein|G-proteins]] and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3763| accessdate = }}</ref>
 
}}
KCNJ6 has been shown to [[Protein-protein interaction|interact]] with [[KCNJ9]]<ref name=pmid10956667>{{cite journal | vauthors = Jelacic TM, Kennedy ME, Wickman K, Clapham DE | title = Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 | journal = J. Biol. Chem. | volume = 275 | issue = 46 | pages = 36211–6 | date = November 2000 | pmid = 10956667 | doi = 10.1074/jbc.M007087200 }}</ref><ref name=pmid12297500>{{cite journal | vauthors = Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH | title = G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase | journal = J. Biol. Chem. | volume = 277 | issue = 48 | pages = 46010–9 | date = November 2002 | pmid = 12297500 | doi = 10.1074/jbc.M205035200 }}</ref> and [[DLG1]].<ref name=pmid10619846>{{cite journal | vauthors = Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y | title = Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain | journal = EMBO J. | volume = 19 | issue = 1 | pages = 78–83 | date = January 2000 | pmid = 10619846 | pmc = 1171779 | doi = 10.1093/emboj/19.1.78 }}</ref>


==See also==
==See also==
Line 59: Line 15:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Patil N, Cox DR, Bhat D, Faham M, Myers RM, Peterson AS | title = A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. | journal = Nat. Genet. | volume = 11 | issue = 2 | pages = 126–9 | year = 1995 | pmid = 7550338 | doi = 10.1038/ng1095-126 }}
| citations =
*{{cite journal | vauthors = Ferrer J, Nichols CG, Makhina EN, Salkoff L, Bernstein J, Gerhard D, Wasson J, Ramanadham S, Permutt A | title = Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. | journal = J. Biol. Chem. | volume = 270 | issue = 44 | pages = 26086–91 | year = 1995 | pmid = 7592809 | doi = 10.1074/jbc.270.44.26086 }}
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
*{{cite journal | vauthors = Tsaur ML, Menzel S, Lai FP, Espinosa R, Concannon P, Spielman RS, Hanis CL, Cox NJ, Le Beau MM, German MS | title = Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM. | journal = Diabetes | volume = 44 | issue = 5 | pages = 592–6 | year = 1995 | pmid = 7729621 | doi = 10.2337/diabetes.44.5.592 }}
*{{cite journal | author=Patil N, Cox DR, Bhat D, ''et al.'' |title=A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. |journal=Nat. Genet. |volume=11 |issue= 2 |pages= 126-9 |year= 1995 |pmid= 7550338 |doi= 10.1038/ng1095-126 }}
*{{cite journal | vauthors = Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP | title = Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. | journal = FEBS Lett. | volume = 353 | issue = 1 | pages = 37–42 | year = 1994 | pmid = 7926018 | doi = 10.1016/0014-5793(94)01007-2 }}
*{{cite journal | author=Ferrer J, Nichols CG, Makhina EN, ''et al.'' |title=Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26086-91 |year= 1995 |pmid= 7592809 |doi= }}
*{{cite journal | vauthors = Liao YJ, Jan YN, Jan LY | title = Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. | journal = J. Neurosci. | volume = 16 | issue = 22 | pages = 7137–50 | year = 1996 | pmid = 8929423 | doi =  }}
*{{cite journal | author=Tsaur ML, Menzel S, Lai FP, ''et al.'' |title=Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM. |journal=Diabetes |volume=44 |issue= 5 |pages= 592-6 |year= 1995 |pmid= 7729621 |doi= }}
*{{cite journal | vauthors = Signorini S, Liao YJ, Duncan SA, Jan LY, Stoffel M | title = Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 3 | pages = 923–7 | year = 1997 | pmid = 9023358 | pmc = 19615 | doi = 10.1073/pnas.94.3.923 }}
*{{cite journal | author=Sakura H, Bond C, Warren-Perry M, ''et al.'' |title=Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit. |journal=FEBS Lett. |volume=367 |issue= 2 |pages= 193-7 |year= 1995 |pmid= 7796919 |doi=  }}
*{{cite journal | vauthors = Ohira M, Seki N, Nagase T, Suzuki E, Nomura N, Ohara O, Hattori M, Sakaki Y, Eki T, Murakami Y, Saito T, Ichikawa H, Ohki M | title = Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. | journal = Genome Res. | volume = 7 | issue = 1 | pages = 47–58 | year = 1997 | pmid = 9037601 | doi = 10.1101/gr.7.1.47 }}
*{{cite journal | author=Lesage F, Duprat F, Fink M, ''et al.'' |title=Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. |journal=FEBS Lett. |volume=353 |issue= 1 |pages= 37-42 |year= 1994 |pmid= 7926018 |doi= }}
*{{cite journal | vauthors = Huang CL, Jan YN, Jan LY | title = Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. | journal = FEBS Lett. | volume = 405 | issue = 3 | pages = 291–8 | year = 1997 | pmid = 9108307 | doi = 10.1016/S0014-5793(97)00197-X }}
*{{cite journal | author=Liao YJ, Jan YN, Jan LY |title=Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. |journal=J. Neurosci. |volume=16 |issue= 22 |pages= 7137-50 |year= 1996 |pmid= 8929423 |doi= }}
*{{cite journal | vauthors = Dahmane N, Ghezala GA, Gosset P, Chamoun Z, Dufresne-Zacharia MC, Lopes C, Rabatel N, Gassanova-Maugenre S, Chettouh Z, Abramowski V, Fayet E, Yaspo ML, Korn B, Blouin JL, Lehrach H, Poutska A, Antonarakis SE, Sinet PM, Créau N, Delabar JM | title = Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. | journal = Genomics | volume = 48 | issue = 1 | pages = 12–23 | year = 1998 | pmid = 9503011 | doi = 10.1006/geno.1997.5146 }}
*{{cite journal | author=Signorini S, Liao YJ, Duncan SA, ''et al.'' |title=Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 3 |pages= 923-7 |year= 1997 |pmid= 9023358 |doi= }}
*{{cite journal | vauthors = Inanobe A, Horio Y, Fujita A, Tanemoto M, Hibino H, Inageda K, Kurachi Y | title = Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. | journal = J. Physiol. | volume = Pt 1 | issue = | pages = 19–30 | year = 2000 | pmid = 10562331 | pmc = 2269641 | doi =  10.1111/j.1469-7793.1999.00019.x| series = 521 }}
*{{cite journal | author=Ohira M, Seki N, Nagase T, ''et al.'' |title=Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. |journal=Genome Res. |volume=7 |issue= 1 |pages= 47-58 |year= 1997 |pmid= 9037601 |doi= }}
*{{cite journal | vauthors = Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y | title = Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain. | journal = EMBO J. | volume = 19 | issue = 1 | pages = 78–83 | year = 2000 | pmid = 10619846 | pmc = 1171779 | doi = 10.1093/emboj/19.1.78 }}
*{{cite journal | author=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291-8 |year= 1997 |pmid= 9108307 |doi=  }}
*{{cite journal | vauthors = Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH | title = Co-expression of human Kir3 subunits can yield channels with different functional properties. | journal = Cell. Signal. | volume = 11 | issue = 12 | pages = 871–83 | year = 2000 | pmid = 10659995 | doi = 10.1016/S0898-6568(99)00059-5 }}
*{{cite journal | author=Dahmane N, Ghezala GA, Gosset P, ''et al.'' |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. |journal=Genomics |volume=48 |issue= 1 |pages= 12-23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146 }}
*{{cite journal | vauthors = Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML | title = The DNA sequence of human chromosome 21. | journal = Nature | volume = 405 | issue = 6784 | pages = 311–9 | year = 2000 | pmid = 10830953 | doi = 10.1038/35012518 }}
*{{cite journal | author=Inanobe A, Horio Y, Fujita A, ''et al.'' |title=Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. |journal=J. Physiol. (Lond.) |volume=521 Pt 1 |issue= |pages= 19-30 |year= 2000 |pmid= 10562331 |doi= }}
*{{cite journal | vauthors = Jelacic TM, Kennedy ME, Wickman K, Clapham DE | title = Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. | journal = J. Biol. Chem. | volume = 275 | issue = 46 | pages = 36211–6 | year = 2000 | pmid = 10956667 | doi = 10.1074/jbc.M007087200 }}
*{{cite journal | author=Hibino H, Inanobe A, Tanemoto M, ''et al.'' |title=Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain. |journal=EMBO J. |volume=19 |issue= 1 |pages= 78-83 |year= 2000 |pmid= 10619846 |doi= 10.1093/emboj/19.1.78 }}
*{{cite journal | vauthors = Chen L, Kawano T, Bajic S, Kaziro Y, Itoh H, Art JJ, Nakajima Y, Nakajima S | title = A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 12 | pages = 8430–5 | year = 2002 | pmid = 12034888 | pmc = 123084 | doi = 10.1073/pnas.122682899 }}
*{{cite journal  | author=Schoots O, Wilson JM, Ethier N, ''et al.'' |title=Co-expression of human Kir3 subunits can yield channels with different functional properties. |journal=Cell. Signal. |volume=11 |issue= 12 |pages= 871-83 |year= 2000 |pmid= 10659995 |doi= }}
*{{cite journal | vauthors = Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH | title = G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. | journal = J. Biol. Chem. | volume = 277 | issue = 48 | pages = 46010–9 | year = 2003 | pmid = 12297500 | doi = 10.1074/jbc.M205035200 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal | vauthors = Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser-Steinecke B, Schreibmayer W, Dessauer CW, Dascal N | title = Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 29174–83 | year = 2003 | pmid = 12743112 | doi = 10.1074/jbc.M304518200 }}
*{{cite journal | author=Jelacic TM, Kennedy ME, Wickman K, Clapham DE |title=Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36211-6 |year= 2000 |pmid= 10956667 |doi= 10.1074/jbc.M007087200 }}
*{{cite journal | author=Chen L, Kawano T, Bajic S, ''et al.'' |title=A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8430-5 |year= 2002 |pmid= 12034888 |doi= 10.1073/pnas.122682899 }}
*{{cite journal | author=Lavine N, Ethier N, Oak JN, ''et al.'' |title=G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46010-9 |year= 2003 |pmid= 12297500 |doi= 10.1074/jbc.M205035200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ivanina T, Rishal I, Varon D, ''et al.'' |title=Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29174-83 |year= 2003 |pmid= 12743112 |doi= 10.1074/jbc.M304518200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|KCNJ6+protein,+human}}
* {{MeshName|KCNJ6+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}

Latest revision as of 09:10, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene.[1][2][3] Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome (KPLBS). [4]

Function

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.[3]

Interactions

KCNJ6 has been shown to interact with KCNJ9[5][6] and DLG1.[7]

See also

References

  1. ↑ Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM (August 1995). "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit". FEBS Lett. 367 (2): 193–7. doi:10.1016/0014-5793(95)00498-X. PMID 7796919.
  2. ↑ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
  3. ↑ 3.0 3.1 "Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6".
  4. ↑ Masotti, Andrea; Uva, Paolo; Davis-Keppen, Laura; Basel-Vanagaite, Lina; Cohen, Lior; Pisaneschi, Elisa; Celluzzi, Antonella; Bencivenga, Paola; Fang, Mingyan (2015-02-05). "Keppen-Lubinsky Syndrome Is Caused by Mutations in the Inwardly Rectifying K+ Channel Encoded by KCNJ6". The American Journal of Human Genetics. 96 (2): 295–300. doi:10.1016/j.ajhg.2014.12.011. ISSN 0002-9297. PMC 4320262. PMID 25620207.
  5. ↑ Jelacic TM, Kennedy ME, Wickman K, Clapham DE (November 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.
  6. ↑ Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
  7. ↑ Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y (January 2000). "Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain". EMBO J. 19 (1): 78–83. doi:10.1093/emboj/19.1.78. PMC 1171779. PMID 10619846.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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