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{{Infobox_gene}}
{{PBB_Controls
'''Potassium voltage-gated channel subfamily A member 2''' also known as '''K<sub>v</sub>1.2''' is a [[protein]] that in humans is encoded by the ''KCNA2'' [[gene]].<ref name="pmid16382104">{{cite journal | vauthors = Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 473–508 | date = December 2005 | pmid = 16382104 | pmc =  | doi = 10.1124/pr.57.4.10 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3737| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_KCNA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dsx.
| PDB = {{PDB2|1dsx}}, {{PDB2|1exb}}, {{PDB2|1qdv}}, {{PDB2|1qdw}}, {{PDB2|2a79}}
| Name = Potassium voltage-gated channel, shaker-related subfamily, member 2
| HGNCid = 6220
| Symbol = KCNA2
| AltSymbols =; HK4; HBK5; HUKIV; KV1.2; MGC50217; MK2; NGK1; RBK2
| OMIM = 176262
| ECnumber = 
| Homologene = 21034
| MGIid = 96659
| GeneAtlas_image1 = PBB_GE_KCNA2_208564_at_tn.png
| Function = {{GNF_GO|id=GO:0005251 |text = delayed rectifier potassium channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3737
    | Hs_Ensembl = ENSG00000177301
    | Hs_RefseqProtein = NP_004965
    | Hs_RefseqmRNA = NM_004974
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 110937725
    | Hs_GenLoc_end = 110975619
    | Hs_Uniprot = P16389
    | Mm_EntrezGene = 16490
    | Mm_Ensembl = ENSMUSG00000040724
    | Mm_RefseqmRNA = NM_008417
    | Mm_RefseqProtein = NP_032443
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 107229623
    | Mm_GenLoc_end = 107234935
    | Mm_Uniprot = P63141
  }}
}}
'''Potassium voltage-gated channel, shaker-related subfamily, member 2''', also known as '''KCNA2''' or '''K<sub>v</sub>1.2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3737| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.<ref name="entrez">{{cite web | title = Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3737| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
KCNA2 has been shown to [[Protein-protein interaction|interact]] with [[KCNA4]],<ref name=pmid10428084>{{cite journal | vauthors = Coleman SK, Newcombe J, Pryke J, Dolly JO | title = Subunit composition of Kv1 channels in human CNS | journal = Journal of Neurochemistry | volume = 73 | issue = 2 | pages = 849–58 | date = August 1999 | pmid = 10428084 | doi = 10.1046/j.1471-4159.1999.0730849.x }}</ref> [[DLG4]],<ref name=pmid12435606>{{cite journal | vauthors = Eldstrom J, Doerksen KW, Steele DF, Fedida D | title = N-terminal PDZ-binding domain in Kv1 potassium channels | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 529–37 | date = November 2002 | pmid = 12435606 | doi = 10.1016/S0014-5793(02)03572-X }}</ref> [[PTPRA]],<ref name=pmid9878055>{{cite journal | vauthors = Tsai W, Morielli AD, Cachero TG, Peralta EG | title = Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity | journal = The EMBO Journal | volume = 18 | issue = 1 | pages = 109–18 | date = January 1999 | pmid = 9878055 | pmc = 1171107 | doi = 10.1093/emboj/18.1.109 }}</ref> [[KCNAB2]],<ref name=pmid10428084/><ref name=pmid8636142>{{cite journal | vauthors = Nakahira K, Shi G, Rhodes KJ, Trimmer JS | title = Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits | journal = The Journal of Biological Chemistry | volume = 271 | issue = 12 | pages = 7084–9 | date = March 1996 | pmid = 8636142 | doi = 10.1074/jbc.271.12.7084 }}</ref> [[RHOA]]<ref name=pmid9635436>{{cite journal | vauthors = Cachero TG, Morielli AD, Peralta EG | title = The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel | journal = Cell | volume = 93 | issue = 6 | pages = 1077–85 | date = June 1998 | pmid = 9635436 | doi = 10.1016/S0092-8674(00)81212-X }}</ref> and [[Cortactin]].<ref name=pmid12151401>{{cite journal | vauthors = Hattan D, Nesti E, Cachero TG, Morielli AD | title = Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin | journal = The Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38596–606 | date = October 2002 | pmid = 12151401 | doi = 10.1074/jbc.M205005200 }}</ref>
 
==Clinical==
 
Mutations in this gene have been associated with [[hereditary spastic paraplegia]].<ref name=Helbig2016>{{cite journal | vauthors = Helbig KL, Hedrich UB, Shinde DN, Krey I, Teichmann AC, Hentschel J, Schubert J, Chamberlin AC, Huether R, Lu HM, Alcaraz WA, Tang S, Jungbluth C, Dugan SL, Vainionpää L, Karle KN, Synofzik M, Schöls L, Schüle R, Lehesjoki AE, Helbig I, Lerche H, Lemke JR | title = A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia | journal = Annals of Neurology | volume = 80 | issue = 4 | date = October 2016 | pmid = 27543892 | pmc = 5129488 | doi = 10.1002/ana.24762 }}</ref>
 
== See also ==
* [[Voltage-gated potassium channel]]
* [[Voltage-gated potassium channel]]
* [[Pandinotoxin]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE | title = Cloning and expression of a rat cardiac delayed rectifier potassium channel | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 17 | pages = 7892–5 | date = September 1991 | pmid = 1715584 | pmc = 52410 | doi = 10.1073/pnas.88.17.7892 }}
| citations =
* {{cite journal | vauthors = Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG | title = Expression and chromosomal localization of a lymphocyte K+ channel gene | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 23 | pages = 9411–5 | date = December 1990 | pmid = 2251283 | pmc = 55175 | doi = 10.1073/pnas.87.23.9411 }}
*{{cite journal | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
* {{cite journal | vauthors = McKinnon D | title = Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family | journal = The Journal of Biological Chemistry | volume = 264 | issue = 14 | pages = 8230–6 | date = May 1989 | pmid = 2722779 | doi =  }}
*{{cite journal | author=Paulmichl M, Nasmith P, Hellmiss R, ''et al.'' |title=Cloning and expression of a rat cardiac delayed rectifier potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7892-5 |year= 1991 |pmid= 1715584 |doi= }}
* {{cite journal | vauthors = Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M | title = Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases | journal = Nature | volume = 378 | issue = 6552 | pages = 85–8 | date = November 1995 | pmid = 7477295 | doi = 10.1038/378085a0 }}
*{{cite journal | author=Grissmer S, Dethlefs B, Wasmuth JJ, ''et al.'' |title=Expression and chromosomal localization of a lymphocyte K+ channel gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9411-5 |year= 1991 |pmid= 2251283 |doi=  }}
* {{cite journal | vauthors = Klocke R, Roberds SL, Tamkun MM, Gronemeier M, Augustin A, Albrecht B, Pongs O, Jockusch H | title = Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal | journal = Genomics | volume = 18 | issue = 3 | pages = 568–74 | date = December 1993 | pmid = 7905852 | doi = 10.1016/S0888-7543(05)80358-1 }}
*{{cite journal | author=McKinnon D |title=Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. |journal=J. Biol. Chem. |volume=264 |issue= 14 |pages= 8230-6 |year= 1989 |pmid= 2722779 |doi= }}
* {{cite journal | vauthors = Ramaswami M, Tanouy M, Mathew MK | title = Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs | journal = Indian Journal of Biochemistry & Biophysics | volume = 31 | issue = 4 | pages = 254–60 | date = August 1994 | pmid = 8002006 | doi =  }}
*{{cite journal | author=Kim E, Niethammer M, Rothschild A, ''et al.'' |title=Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. |journal=Nature |volume=378 |issue= 6552 |pages= 85-8 |year= 1995 |pmid= 7477295 |doi= 10.1038/378085a0 }}
* {{cite journal | vauthors = Nakahira K, Shi G, Rhodes KJ, Trimmer JS | title = Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits | journal = The Journal of Biological Chemistry | volume = 271 | issue = 12 | pages = 7084–9 | date = March 1996 | pmid = 8636142 | doi = 10.1074/jbc.271.12.7084 }}
*{{cite journal | author=Klocke R, Roberds SL, Tamkun MM, ''et al.'' |title=Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. |journal=Genomics |volume=18 |issue= 3 |pages= 568-74 |year= 1994 |pmid= 7905852 |doi=  }}
* {{cite journal | vauthors = Adda S, Fleischmann BK, Freedman BD, Yu M, Hay DW, Kotlikoff MI | title = Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 13239–43 | date = May 1996 | pmid = 8662756 | doi = 10.1074/jbc.271.22.13239 }}
*{{cite journal | author=Ramaswami M, Tanouy M, Mathew MK |title=Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs. |journal=Indian J. Biochem. Biophys. |volume=31 |issue= 4 |pages= 254-60 |year= 1995 |pmid= 8002006 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Nakahira K, Shi G, Rhodes KJ, Trimmer JS |title=Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7084-9 |year= 1996 |pmid= 8636142 |doi= }}
* {{cite journal | vauthors = Kim E, Sheng M | title = Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases | journal = Neuropharmacology | volume = 35 | issue = 7 | pages = 993–1000 | year = 1997 | pmid = 8938729 | doi = 10.1016/0028-3908(96)00093-7 }}
*{{cite journal | author=Adda S, Fleischmann BK, Freedman BD, ''et al.'' |title=Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 13239-43 |year= 1996 |pmid= 8662756 |doi= }}
* {{cite journal | vauthors = Cachero TG, Morielli AD, Peralta EG | title = The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel | journal = Cell | volume = 93 | issue = 6 | pages = 1077–85 | date = June 1998 | pmid = 9635436 | doi = 10.1016/S0092-8674(00)81212-X }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Tsai W, Morielli AD, Cachero TG, Peralta EG | title = Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity | journal = The EMBO Journal | volume = 18 | issue = 1 | pages = 109–18 | date = January 1999 | pmid = 9878055 | pmc = 1171107 | doi = 10.1093/emboj/18.1.109 }}
*{{cite journal | author=Kim E, Sheng M |title=Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. |journal=Neuropharmacology |volume=35 |issue= 7 |pages= 993-1000 |year= 1997 |pmid= 8938729 |doi= }}
* {{cite journal | vauthors = Coleman SK, Newcombe J, Pryke J, Dolly JO | title = Subunit composition of Kv1 channels in human CNS | journal = Journal of Neurochemistry | volume = 73 | issue = 2 | pages = 849–58 | date = August 1999 | pmid = 10428084 | doi = 10.1046/j.1471-4159.1999.0730849.x }}
*{{cite journal | author=Cachero TG, Morielli AD, Peralta EG |title=The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. |journal=Cell |volume=93 |issue= 6 |pages= 1077-85 |year= 1998 |pmid= 9635436 |doi= }}
* {{cite journal | vauthors = D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M | title = Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function | journal = FASEB Journal | volume = 13 | issue = 11 | pages = 1335–45 | date = August 1999 | pmid = 10428758 | doi =  }}
*{{cite journal | author=Tsai W, Morielli AD, Cachero TG, Peralta EG |title=Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity. |journal=EMBO J. |volume=18 |issue= 1 |pages= 109-18 |year= 1999 |pmid= 9878055 |doi= 10.1093/emboj/18.1.109 }}
* {{cite journal | vauthors = Wade GR, Laurier LG, Preiksaitis HG, Sims SM | title = Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction | journal = The American Journal of Physiology | volume = 277 | issue = 4 Pt 1 | pages = G885-95 | date = October 1999 | pmid = 10516156 | doi =  }}
*{{cite journal | author=Coleman SK, Newcombe J, Pryke J, Dolly JO |title=Subunit composition of Kv1 channels in human CNS. |journal=J. Neurochem. |volume=73 |issue= 2 |pages= 849-58 |year= 1999 |pmid= 10428084 |doi=  }}
* {{cite journal | vauthors = Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E | title = Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels | journal = Neuron | volume = 24 | issue = 4 | pages = 1037–47 | date = December 1999 | pmid = 10624965 | doi = 10.1016/S0896-6273(00)81049-1 }}
*{{cite journal | author=D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M |title=Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function. |journal=FASEB J. |volume=13 |issue= 11 |pages= 1335-45 |year= 1999 |pmid= 10428758 |doi=  }}
* {{cite journal | vauthors = Manganas LN, Trimmer JS | title = Subunit composition determines Kv1 potassium channel surface expression | journal = The Journal of Biological Chemistry | volume = 275 | issue = 38 | pages = 29685–93 | date = September 2000 | pmid = 10896669 | doi = 10.1074/jbc.M005010200 }}
*{{cite journal | author=Wade GR, Laurier LG, Preiksaitis HG, Sims SM |title=Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction. |journal=Am. J. Physiol. |volume=277 |issue= 4 Pt 1 |pages= G885-95 |year= 1999 |pmid= 10516156 |doi= }}
* {{cite journal | vauthors = Kuryshev YA, Wible BA, Gudz TI, Ramirez AN, Brown AM | title = KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression | journal = American Journal of Physiology. Cell Physiology | volume = 281 | issue = 1 | pages = C290-9 | date = July 2001 | pmid = 11401852 | doi = }}
*{{cite journal | author=Poliak S, Gollan L, Martinez R, ''et al.'' |title=Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. |journal=Neuron |volume=24 |issue= 4 |pages= 1037-47 |year= 2000 |pmid= 10624965 |doi= }}
* {{cite journal | vauthors = Byron KL, Lucchesi PA | title = Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7298–307 | date = March 2002 | pmid = 11739373 | doi = 10.1074/jbc.M104726200 }}
*{{cite journal | author=Manganas LN, Trimmer JS |title=Subunit composition determines Kv1 potassium channel surface expression. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29685-93 |year= 2000 |pmid= 10896669 |doi= 10.1074/jbc.M005010200 }}
*{{cite journal | author=Kuryshev YA, Wible BA, Gudz TI, ''et al.'' |title=KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 1 |pages= C290-9 |year= 2001 |pmid= 11401852 |doi=  }}
*{{cite journal  | author=Byron KL, Lucchesi PA |title=Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7298-307 |year= 2002 |pmid= 11739373 |doi= 10.1074/jbc.M104726200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|KCNA2+protein,+human}}
* {{MeshName|KCNA2+protein,+human}}


{{membrane-protein-stub}}
{{PDB Gallery|geneid=3737}}
{{Ion channels|g3}}
 
{{NLM content}}
{{NLM content}}
{{Ion channels}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}

Revision as of 21:43, 11 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene.[1][2]

Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.[2]

Interactions

KCNA2 has been shown to interact with KCNA4,[3] DLG4,[4] PTPRA,[5] KCNAB2,[3][6] RHOA[7] and Cortactin.[8]

Clinical

Mutations in this gene have been associated with hereditary spastic paraplegia.[9]

See also

References

  1. ↑ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
  2. ↑ 2.0 2.1 "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2".
  3. ↑ 3.0 3.1 Coleman SK, Newcombe J, Pryke J, Dolly JO (August 1999). "Subunit composition of Kv1 channels in human CNS". Journal of Neurochemistry. 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084.
  4. ↑ Eldstrom J, Doerksen KW, Steele DF, Fedida D (November 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters. 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID 12435606.
  5. ↑ Tsai W, Morielli AD, Cachero TG, Peralta EG (January 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". The EMBO Journal. 18 (1): 109–18. doi:10.1093/emboj/18.1.109. PMC 1171107. PMID 9878055.
  6. ↑ Nakahira K, Shi G, Rhodes KJ, Trimmer JS (March 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". The Journal of Biological Chemistry. 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142.
  7. ↑ Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel". Cell. 93 (6): 1077–85. doi:10.1016/S0092-8674(00)81212-X. PMID 9635436.
  8. ↑ Hattan D, Nesti E, Cachero TG, Morielli AD (October 2002). "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of Biological Chemistry. 277 (41): 38596–606. doi:10.1074/jbc.M205005200. PMID 12151401.
  9. ↑ Helbig KL, Hedrich UB, Shinde DN, Krey I, Teichmann AC, Hentschel J, Schubert J, Chamberlin AC, Huether R, Lu HM, Alcaraz WA, Tang S, Jungbluth C, Dugan SL, Vainionpää L, Karle KN, Synofzik M, Schöls L, Schüle R, Lehesjoki AE, Helbig I, Lerche H, Lemke JR (October 2016). "A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia". Annals of Neurology. 80 (4). doi:10.1002/ana.24762. PMC 5129488. PMID 27543892.

Further reading

  • Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE (September 1991). "Cloning and expression of a rat cardiac delayed rectifier potassium channel". Proceedings of the National Academy of Sciences of the United States of America. 88 (17): 7892–5. doi:10.1073/pnas.88.17.7892. PMC 52410. PMID 1715584.
  • Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG (December 1990). "Expression and chromosomal localization of a lymphocyte K+ channel gene". Proceedings of the National Academy of Sciences of the United States of America. 87 (23): 9411–5. doi:10.1073/pnas.87.23.9411. PMC 55175. PMID 2251283.
  • McKinnon D (May 1989). "Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family". The Journal of Biological Chemistry. 264 (14): 8230–6. PMID 2722779.
  • Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M (November 1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases". Nature. 378 (6552): 85–8. doi:10.1038/378085a0. PMID 7477295.
  • Klocke R, Roberds SL, Tamkun MM, Gronemeier M, Augustin A, Albrecht B, Pongs O, Jockusch H (December 1993). "Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal". Genomics. 18 (3): 568–74. doi:10.1016/S0888-7543(05)80358-1. PMID 7905852.
  • Ramaswami M, Tanouy M, Mathew MK (August 1994). "Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs". Indian Journal of Biochemistry & Biophysics. 31 (4): 254–60. PMID 8002006.
  • Nakahira K, Shi G, Rhodes KJ, Trimmer JS (March 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". The Journal of Biological Chemistry. 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142.
  • Adda S, Fleischmann BK, Freedman BD, Yu M, Hay DW, Kotlikoff MI (May 1996). "Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle". The Journal of Biological Chemistry. 271 (22): 13239–43. doi:10.1074/jbc.271.22.13239. PMID 8662756.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Kim E, Sheng M (1997). "Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases". Neuropharmacology. 35 (7): 993–1000. doi:10.1016/0028-3908(96)00093-7. PMID 8938729.
  • Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel". Cell. 93 (6): 1077–85. doi:10.1016/S0092-8674(00)81212-X. PMID 9635436.
  • Tsai W, Morielli AD, Cachero TG, Peralta EG (January 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". The EMBO Journal. 18 (1): 109–18. doi:10.1093/emboj/18.1.109. PMC 1171107. PMID 9878055.
  • Coleman SK, Newcombe J, Pryke J, Dolly JO (August 1999). "Subunit composition of Kv1 channels in human CNS". Journal of Neurochemistry. 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084.
  • D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M (August 1999). "Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function". FASEB Journal. 13 (11): 1335–45. PMID 10428758.
  • Wade GR, Laurier LG, Preiksaitis HG, Sims SM (October 1999). "Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction". The American Journal of Physiology. 277 (4 Pt 1): G885–95. PMID 10516156.
  • Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E (December 1999). "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels". Neuron. 24 (4): 1037–47. doi:10.1016/S0896-6273(00)81049-1. PMID 10624965.
  • Manganas LN, Trimmer JS (September 2000). "Subunit composition determines Kv1 potassium channel surface expression". The Journal of Biological Chemistry. 275 (38): 29685–93. doi:10.1074/jbc.M005010200. PMID 10896669.
  • Kuryshev YA, Wible BA, Gudz TI, Ramirez AN, Brown AM (July 2001). "KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression". American Journal of Physiology. Cell Physiology. 281 (1): C290–9. PMID 11401852.
  • Byron KL, Lucchesi PA (March 2002). "Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking". The Journal of Biological Chemistry. 277 (9): 7298–307. doi:10.1074/jbc.M104726200. PMID 11739373.

External links

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