Irritable bowel syndrome causes: Difference between revisions
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==Overview== | ==Overview== | ||
There is no definite cause that has been established for irritable bowel syndrome (IBS). However, many factors contribute to the development of IBS such as emotional disturbances, stress, adverse early life events, history of inflammatory bowel disease, and acute gastrointestinal [[Infection|infections]]. Less common causes of IBS include [[genetics]] and [[Hormone|hormonal]] changes. | There is no definite cause that has been established for irritable bowel syndrome (IBS). However, many factors contribute to the development of IBS such as emotional disturbances, stress, adverse early life events, history of [[inflammatory bowel disease]], and acute gastrointestinal [[Infection|infections]]. Less common causes of IBS include [[genetics]] and [[Hormone|hormonal]] changes. | ||
==Causes== | ==Causes== | ||
Revision as of 16:48, 26 October 2017
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Differentiating Irritable bowel syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There is no definite cause that has been established for irritable bowel syndrome (IBS). However, many factors contribute to the development of IBS such as emotional disturbances, stress, adverse early life events, history of inflammatory bowel disease, and acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes.
Causes
Irritable bowel syndrome (IBS) results from a complex interaction among multiple factors. These may include psychological, epidemiological, genetic, and infectious factors. To review these factors in detail, click here.
Genetic Causes
Genetic causes of inflammatory bowel disease (IBS) include:[1]
- IBS is caused by a mutation of type V (alpha subunit) of SCN5A-encoded voltage gated sodium channel gene.
- Other genes such as tumor necrosis factor alpha (TNFα) and genes coding for superfamily member 15 (TNFSF15) are also involved.
- SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation, and epithelial barriers.
- Genes involved in the regulation of hepatic bile acid synthesis such as a functional Klothoβ gene variant are mutated in IBS patients.
- Genome wide DNA methylation profiling is different in IBS patients, especially involving genes linked to neuropeptide hormone function and oxidative stress.
References
- ↑ Makker J, Chilimuri S, Bella JN (2015). "Genetic epidemiology of irritable bowel syndrome". World J. Gastroenterol. 21 (40): 11353–61. doi:10.3748/wjg.v21.i40.11353. PMC 4616211. PMID 26525775.