High triglyceride causes: Difference between revisions

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*[[Diabetes mellitus]]
*[[Diabetes mellitus]]
*[[Obesity]]
*[[Obesity]]
===Primary hypertriglyceridemia===
====Genetics <ref name="pmid19355858">{{cite journal| author=Kolovou GD, Anagnostopoulou KK, Kostakou PM, Bilianou H, Mikhailidis DP| title=Primary and secondary hypertriglyceridaemia. | journal=Curr Drug Targets | year= 2009 | volume= 10 | issue= 4 | pages= 336-43 | pmid=19355858 | doi= | pmc= | url= }} </ref>====
=====Type I hyperlipoproteinemia=====
* [[Genetic]] deficiency or dysfunction of enzyme [[lipoprotein lipase]] (LPL)
* Deficiency of apo C-II, that acts as a cofactor of [[LPL]]
* Insulin deficiency or dysfunction in [[diabetes]] type 1 and 2 can also cause this disorder as LPL requires insulin for its full function.
=====Familial combined hyperlipidemia=====
* [[Autosomal dominant]] disorder
* Patients have either isolated [[triglyceride]] or LDL-c elevations or both.
* Family history of premature [[coronary artery disease]]  in 1 or more first-degree relatives
* Family history for elevated triglycerides with or without elevated LDL-c levels.
=====Familial hypertriglyceridemia=====
* Autosomal dominant trait
* These patients and their families have isolated triglyceride elevations
* Increased risk of premature coronary artery disease.
===Idiopathic (constitutional)===
===Secondary hypertriglyceridemia===
===Metabolic <ref name="pmid19355858">{{cite journal| author=Kolovou GD, Anagnostopoulou KK, Kostakou PM, Bilianou H, Mikhailidis DP| title=Primary and secondary hypertriglyceridaemia. | journal=Curr Drug Targets | year= 2009 | volume= 10 | issue= 4 | pages= 336-43 | pmid=19355858 | doi= | pmc= | url= }} </ref>===
* [[Diabetes mellitus]] and [[insulin resistance]]
* [[Obesity]]
* [[Hypothyroidism]]
* [[Nephrotic syndrome]]
* [[Renal failure]]
===Drugs===
* [[Diuretics]] (high dose [[thiazide]] or [[chlorthalidone]])
* [[Beta-blockers]] (high doses)
* [[Estrogen replacement therapy]]
* [[Oral contraceptive pills]] (high [[estrogen]] )
* [[Tamoxifen]]
* [[Glucocorticoids]]
* Oral [[isotretinoin]]
* [[Antiretroviral therapy]] ([[protease inhibitors]], [[nonnucleoside reverse transcriptase inhibitors]])
* Atypical [[antipsychotics]]
===Miscellaneous===
* [[Alcohol]]
* [[Pregnancy]]
* [[Acute pancreatitis]]
* [[Nonalcoholic fatty liver]] disorder
* High-carbohydrate or [[high glycemic index]]
* [[Glycogen storage disease]] type 1
* [[Lysosomal acid lipase deficiency]] or [[Cholesteryl ester storage disease]]
* [[Paraproteinemia]]s (e.g., [[hypergammaglobulinemia]] in [[macroglobulinemia]], [[myeloma]], [[lymphoma]] and [[lymphocytic leukemias]])
* [[Autoimmune]] disorders (e.g., [[systemic lupus erythematosis]])


==References==
==References==

Revision as of 19:11, 24 September 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

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Hypertriglyceridemia can occur due to various causes, including genetics, familial, metabolic and drugs

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