Heartburn causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Divya Yadav MD [2] Luke Rusowicz-Orazem, B.S.

Overview

Heartburn is commonly caused by sources of acid reflux, including adverse reactions with various food and drugs. Other causes are far less common, but are potentially life-threatening.

Causes

Heartburn is commonly caused by sources of acid reflux, including adverse reactions with various food and drugs.
Esophageal and gastrointestinal cancer are potentially life threatening causes of heartburn and require prompt diagnosis and management.

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular Celiac artery stenosis , Diffuse systemic sclerosi  , Nocturnal heartburn  , Pylephlebitis 
Chemical/Poisoning 1,2-dibromo-3-chloropropane  , Acid regurgitation, Alcohol, Aromatic amino acid decarboxylase deficiency  , Callistin shellfish poisoning  , Citrus fruit, Copper toxicity  , Niacin toxicity  , Nickel carbonyl  , Pollen food allergy syndrome  , Pyresmethrin  , Silafluofen  , Smoking, Sodas , Sulfite  , Tobacco products , Tomatoes , Vinyl choride
Dental No underlying causes
Dermatologic Scleroderma
Drug Side Effect Acrinathrin  , Alpha-cypermethrin  , Amines  , Barthrin  , Beta-cyfluthrin  , Beta-cypermethrin  , Bifenthrin  , Bioallethrin  , Bioehtanomethrin  , Biopermethrin  , Bioresmethrin, Caffeine , Cismethrin  , Cyclethrin  , Cyfluthrin  , Cyhalothrin  , Cyllprothrin  , Cyphenothrin  , Deltamethrin  , Dimefluthrin, Dimethrin  , Empenthrin  , Esfenvalerate  , Fenfluthrin, Fenpirithrin  , Fenpropathrin  , Fenvalerate  , Flucythrinate  , Flufenprox  , Flurbiprofen, Fluvalinate  , Furethrin  , Gamma-cyhalothrin  , Glucosamine , Halfenprox  , Ibuprofen, Imiprothrin  , Indinavir, Ketorolac tromethamine, Lambda-cyhalothrin  , Methamphetamine , Methylene dianiline  , Metofluthrin  , Oxaprozin, Piroxicam, Prallethrin  , Profluthrin  , Protrifenbute  , Pyrethroid  , Salicylate  , Tau-fluvalinate  , Tefluthrin  , Theta-cypermethrin  , Tolbutamide, Tralomethrin  , Transfluthrin  , Transpermethrin, Zeta-cypermethrin 
Ear Nose Throat Achalasia cardia, Sjogren's syndrome 
Endocrine Carnitine-acylcarnitine translocase deficiency  , Secondary hyperparathyroidism 
Environmental No underlying causes
Gastroenterologic Achalasia cardia, Acute gastritis, Acute oesophagitis, Barrett esophagus  , Celiac artery stenosis , Crohn's disease of the esophagus  , Decreased gastrointestinal motility  , Esophageal carcinoma  , Esophageal ulcer  , Esophagus cancer  , Gastric lymphoma  , Gastroesophageal reflux disease  , Gastrointestinal motility disorders, Indigestion  , Janbon syndrome  , Microgastria short stature diabetes  , Mitochondrial neurogastrointestinal encephalopathy syndrome, Peptic ulcer, Reflux  , Sandifer syndrome  , Schatzki ring  , Short bowel syndrome  , Stomach cancer  , Stomach emptying disorders, Weak esophageal muscles, Zieve syndrome  , Zollinger-ellison syndrome
Genetic Bbb syndrome, Brachmann-de lange syndrome  , Chromosome 12p tetrasomy syndrome  , Chromosome 1p deletion syndrome  , Chromosome 22q deletion syndrome  , Chromosome 9q deletion syndrome  , Congenital microgastria limb reduction defect  , Cornelia de lange syndrome 1  , Deletion of the short arm of chromosome 1  , Emanuel syndrome, Hypertelorism, Nyssen-van bogaert syndrome  , Opitz syndrome , Pallister-killian syndrome, Smith-lemli-opitz syndrome  , Wagr syndrome  , Worster drought syndrome  , X-linked alpha thalassemia mental retardation syndrome
Hematologic Carnitine-acylcarnitine translocase deficiency  , Familial infantile metachromatic leukodystrophy , Microgastria short stature diabetes  , Velocardiofacial syndrome  , Wilms tumor
Iatrogenic No underlying causes
Infectious Disease Ankylostomiasis  , Fascioliasis  , Helicobacter pylori bacteria, Pylephlebitis  , Strongyloidiasis 
Musculoskeletal/Orthopedic Congenital microgastria limb reduction defect  , Rest syndrome, Spastic paraplegia 9
Neurologic Mental retardation, Mitochondrial neurogastrointestinal encephalopathy syndrome, Polyneuropathy , Rest syndrome, Sleep apnea syndromes  , Spastic paraplegia 9, X-linked alpha thalassemia mental retardation syndrome
Nutritional/Metabolic Chocolate, Citrus fruit, Fatty foods , Food additives  , Garlic, Msg  , Naproxen sodium, Peanuts, Peppermint , Red pepper , Sodas , Spicy foods, Tomatoes , Wine
Obstetric/Gynecologic Pregnancy
Oncologic Esophagus cancer  , Gastric lymphoma  , Lymphoma, Stomach cancer  , Wilms tumor , Zollinger-ellison syndrome
Ophthalmologic No underlying causes
Overdose/Toxicity Alcohol, Caffeine , Peanuts, Peppermint , Pollen food allergy syndrome 
Psychiatric Stress
Pulmonary Mediastinitis  , Sleep apnea syndromes 
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Allergenic cross-reactivity  , Gluten allergy  , Grain-based foods, Scleroderma 
Sexual No underlying causes
Trauma Hiatus hernia
Urologic Hypospadias
Miscellaneous No underlying causes

Causes in Alphabetical Order

References