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__NOTOC__
__NOTOC__
{{Hantavirus pulmonary syndrome}}
{{Hantavirus infection}}
{{CMG}} {{AE}} {{MMF}}
==Overview==
The symptoms of hantavirus infection may include sudden [[fever]], [[prostration]], [[myalgia]], and [[abdominal discomfort]]. [[Pulmonary]] and [[hemorrhagic]] symptoms may also arise in severe disease.


{{CMG}}
==History and symptoms==
===History===
Patient usually presents with history of flu-like illness. History of rodent or rodent dropping contact may be helpful.<ref name="pmid8004332">{{cite journal |vauthors=Levy H, Simpson SQ |title=Hantavirus pulmonary syndrome |journal=Am. J. Respir. Crit. Care Med. |volume=149 |issue=6 |pages=1710–3 |year=1994 |pmid=8004332 |doi=10.1164/ajrccm.149.6.8004332 |url=}}</ref>
===Common symptoms===
The common symptoms of hantavirus infection are:<ref name="pmid28120221">{{cite journal |vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X |title=Hantavirus infection: a global zoonotic challenge |journal=Virol Sin |volume=32 |issue=1 |pages=32–43 |year=2017 |pmid=28120221 |doi=10.1007/s12250-016-3899-x |url=}}</ref>
*Sudden [[fever]]
*[[Prostration]]
*[[Myalgia]]
*[[Abdominal discomfort]]


==Symptoms==
===Less common symptoms===
'''Early symptoms'''
In severe disease (cardiopulmonary or hemorrhagic fever), hantavirus infection can cause the following symptoms:The common symptoms of hantavirus infection are:<ref name="pmid28120221">{{cite journal |vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X |title=Hantavirus infection: a global zoonotic challenge |journal=Virol Sin |volume=32 |issue=1 |pages=32–43 |year=2017 |pmid=28120221 |doi=10.1007/s12250-016-3899-x |url=}}</ref>
*Dry [[cough]]
*Rapidly increasing [[dyspnea]]
*[[Petechiae]]
*Inflammatory symptoms of the eye
*Acute [[myopia]]
*[[Altered mental status]]
*[[Hypotension]]
===Symptomatic stages of Hantavirus hemorrhagic fever with renal syndrome===
On the basis of symptoms, hemorrhagic fever with renal syndrome caused by hantavirus infection is divided into the following stages:<ref name="pmid28120221">{{cite journal |vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X |title=Hantavirus infection: a global zoonotic challenge |journal=Virol Sin |volume=32 |issue=1 |pages=32–43 |year=2017 |pmid=28120221 |doi=10.1007/s12250-016-3899-x |url=}}</ref><ref name="pmid12521363">{{cite journal |vauthors=Lednicky JA |title=Hantaviruses. a short review |journal=Arch. Pathol. Lab. Med. |volume=127 |issue=1 |pages=30–5 |year=2003 |pmid=12521363 |doi=10.1043/0003-9985(2003)127<30:>2.0.CO;2 |url=}}</ref><ref name="pmid22553984">{{cite journal |vauthors=Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G |title=Hantavirus infections for the clinician: from case presentation to diagnosis and treatment |journal=Crit. Rev. Microbiol. |volume=38 |issue=4 |pages=317–29 |year=2012 |pmid=22553984 |doi=10.3109/1040841X.2012.673553 |url=}}</ref>
#Prodormal or Febrile phase(3-5 days):It may include
#*[[Fever]]
#*[[Headache]]
#*[[Malaise]]
#*[[Myalgia]]
#*[[Abdominal discomfort]]
#Hemorrhagic phase(1-2 days): It may include
#*[[Flushing]] of the face
#*[[Conjunctival injection|Injection of the conjunctiva]]
#*[[Bleeding]] from mucous membranes
#*[[Petechial rash]]
#*[[Nausea and vomiting]]
#*[[Hypotension]]
#*[[Confusion]]
#*[[Cold]] skin
#Oliguric phase (3-5 days):
#*Decreased urine output which may result in [[renal failure]]
#*Resolution of petechiae and flushing
#Polyuric phase:
#*Onset of [[diuresis]]
#*Clinical improvement
#Convalescent phase (weeks to months):
#*[[Muscle weakness]]
#*Hyposthenuria
#*[[Polyuria]]


Early symptoms include fatigue, fever and muscle aches, especially in the large muscle groups-thighs, hips, back, and sometimes shoulders. These symptoms are universal.
===Symptomatic stages of Hantavirus cardiopulmonary syndrome===
On the basis of symptoms, cardiopulmonary syndrome caused by hantavirus infection is divided into the following stages:<ref name="pmid8004332">{{cite journal |vauthors=Levy H, Simpson SQ |title=Hantavirus pulmonary syndrome |journal=Am. J. Respir. Crit. Care Med. |volume=149 |issue=6 |pages=1710–3 |year=1994 |pmid=8004332 |doi=10.1164/ajrccm.149.6.8004332 |url=}}</ref><ref name="pmid28120221">{{cite journal |vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X |title=Hantavirus infection: a global zoonotic challenge |journal=Virol Sin |volume=32 |issue=1 |pages=32–43 |year=2017 |pmid=28120221 |doi=10.1007/s12250-016-3899-x |url=}}</ref><ref name="pmid12521363">{{cite journal |vauthors=Lednicky JA |title=Hantaviruses. a short review |journal=Arch. Pathol. Lab. Med. |volume=127 |issue=1 |pages=30–5 |year=2003 |pmid=12521363 |doi=10.1043/0003-9985(2003)127<30:>2.0.CO;2 |url=}}</ref><ref name="pmid22553984">{{cite journal |vauthors=Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G |title=Hantavirus infections for the clinician: from case presentation to diagnosis and treatment |journal=Crit. Rev. Microbiol. |volume=38 |issue=4 |pages=317–29 |year=2012 |pmid=22553984 |doi=10.3109/1040841X.2012.673553 |url=}}</ref>
#Prodormal or febrile stage (3-5 days) : It may include
#*[[Fever]]
#*[[Headache]]
#*[[Malaise]]
#*[[Myalgia]]
#*[[Abdominal discomfort]]
#Cardiopulmonary phase (5-7 days):
#*[[Cough]]
#*[[Dyspnea]]
#*[[Chest pain]]
#*[[Cyanosis]]
#*[[Shock]]
#Polyuric phase (2-3 days):
#*Onset of [[diuresis]]
#*Clinical improvement
#Convalescent phase (months to years):
#*[[Fatigue]]
#*[[Weakness]]
#*Impaired cognitive function


There may also be headaches, dizziness, chills, and abdominal problems, such as nausea, vomiting, diarrhea, and abdominal pain. About half of all HPS patients experience these symptoms.
==References==
{{Reflist|2}}


'''Late symptoms'''
{{WH}}
{{WikiDoc Sources}}


Four to 10 days after the initial phase of illness, the late symptoms of HPS appear. These include coughing and shortness of breath, with the sensation of, as one survivor put it, a "...tight band around my chest and a pillow over my face" as the lungs fill with fluid.
[[Category:Viral diseases]]
 
'''Uncommon symptoms'''
 
Earache, sore throat, runny nose, and rash are very uncommon symptoms of HPS.
 
'''Incubation period'''
 
Due to the small number of HPS cases, the "incubation time" is not positively known. However, on the basis of limited information, it appears that symptoms may develop between 1 and 5 weeks after exposure to urine, droppings, or saliva of infected rodents.
 
Another important point to remember from the data that the CDC Special Pathogens Branch keeps on all reported cases of HPS, is that it appears many people who have become ill were in a situation where they did not see rodents or rodent droppings. Other people have had frequent contact with rodents and their droppings before becoming ill. This apparent inconsistency makes it very difficult to pin down the precise time when the virus was transmitted.
 
==References==
{{Reflist|2}}
http://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/symptoms.htm
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Latest revision as of 21:57, 29 July 2020

Hantavirus infection Microchapters

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Hantavirus cardiopulmonary syndrome (HCPS) (patient information)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The symptoms of hantavirus infection may include sudden fever, prostration, myalgia, and abdominal discomfort. Pulmonary and hemorrhagic symptoms may also arise in severe disease.

History and symptoms

History

Patient usually presents with history of flu-like illness. History of rodent or rodent dropping contact may be helpful.[1]

Common symptoms

The common symptoms of hantavirus infection are:[2]

Less common symptoms

In severe disease (cardiopulmonary or hemorrhagic fever), hantavirus infection can cause the following symptoms:The common symptoms of hantavirus infection are:[2]

Symptomatic stages of Hantavirus hemorrhagic fever with renal syndrome

On the basis of symptoms, hemorrhagic fever with renal syndrome caused by hantavirus infection is divided into the following stages:[2][3][4]

  1. Prodormal or Febrile phase(3-5 days):It may include
  2. Hemorrhagic phase(1-2 days): It may include
  3. Oliguric phase (3-5 days):
    • Decreased urine output which may result in renal failure
    • Resolution of petechiae and flushing
  4. Polyuric phase:
  5. Convalescent phase (weeks to months):

Symptomatic stages of Hantavirus cardiopulmonary syndrome

On the basis of symptoms, cardiopulmonary syndrome caused by hantavirus infection is divided into the following stages:[1][2][3][4]

  1. Prodormal or febrile stage (3-5 days) : It may include
  2. Cardiopulmonary phase (5-7 days):
  3. Polyuric phase (2-3 days):
  4. Convalescent phase (months to years):

References

  1. ↑ 1.0 1.1 Levy H, Simpson SQ (1994). "Hantavirus pulmonary syndrome". Am. J. Respir. Crit. Care Med. 149 (6): 1710–3. doi:10.1164/ajrccm.149.6.8004332. PMID 8004332.
  2. ↑ 2.0 2.1 2.2 2.3 Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X (2017). "Hantavirus infection: a global zoonotic challenge". Virol Sin. 32 (1): 32–43. doi:10.1007/s12250-016-3899-x. PMID 28120221.
  3. ↑ 3.0 3.1 Lednicky JA (2003). "Hantaviruses. a short review". Arch. Pathol. Lab. Med. 127 (1): 30–5. doi:10.1043/0003-9985(2003)127<30:>2.0.CO;2. PMID 12521363.
  4. ↑ 4.0 4.1 Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G (2012). "Hantavirus infections for the clinician: from case presentation to diagnosis and treatment". Crit. Rev. Microbiol. 38 (4): 317–29. doi:10.3109/1040841X.2012.673553. PMID 22553984.

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