Group B streptococcal infection medical therapy

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Group B Streptococcal Infection Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

Overview

Medical Therapy

Empirical Antibiotic Therapy in Neonatal Meningitis

GBS should be suspected as a causative agent for bacterial meningitis in infants less than two years of age for whom empirical antibiotic therapy should be initiated immediately.

Age Possible pathogens causing the bacterial meningitis Empirical treatment
< 1 month Streptococcus agalactiae
Escherichia coli
Listeria monocytogenes
Klebsiella
Ampicillin + cefotaxime
OR
Ampicillin + aminoglycoside
1-23 months Streptococcus pneumoniae
Neisseria meningitidis
Streptococcus agalactiae
Haemophilus influenzae
E. coli
Vancomycin + third generation cephalosporin

Targeted Antibiotic Therapy in Neonatal Meningitis

Recommended therapy for GBS meningitis Alternative therapy for GBS meningitis
Ampicillin
OR
Penicillin
Consider adding an aminoglycoside
Third generation cephalosporin
(Ceftriaxone or cefotaxime)

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