Goodpasture syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
There are no known direct causes for Goodpasture syndrome. Common risk factors for Goodpasture syndrome are viral or bacterial infections and certain environmental and behavioral risk factors such as smoking, hydrocarbons, formaldehyde and cocaine use.[1]
Causes
Goodpasture syndrome may be caused by either viral or bacterial infections, occupational, environmental or behavioral risk factors.
Viral and bacterial risk factors causing Goodpasture syndrome
It is not clear how bacterial or viral infections play a role in Goodpasture syndrome. However, it is presumed that infections such as the influenza virus may play a role in the disease because of cross-reactivity in the basement membrane.[2]
Occupational, Environmental and Behavioral risk factors causing Goodpasture syndrome[1]
Occupational, environmental and behavioral risk factors that cause Goodpasture syndrome include:
- Smoking tobacco
- Exposure to organic solvents
- Exposure to hydrocarbons
- Cocaine
Goodpasture syndrome is an autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Persons with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomureli) of the kidney.
These substances are called anti-glomerular basement membrane antibodies. Glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane are antibodies against this membrane. They can lead to kidney damage.
Sometimes the disorder is triggered by a viral respiratory infection or by breathing in hydrocarbon solvents. In such cases, the immune system may attack organs or tissues because it mistakes them for these viruses or foreign chemicals.
The immune system's faulty response causes bleeding in the air sacs and inflammation in the kidney's filtering units.
Drug Induced
- Penicillamine
References
- ↑ 1.0 1.1 Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
- ↑ Wilson CB, Dixon FJ (1973). "Anti-glomerular basement membrane antibody-induced glomerulonephritis". Kidney Int. 3 (2): 74–89. PMID 4571918.