Gliomatosis cerebri medical therapy: Difference between revisions

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==Overview==
==Overview==
[[Radiotherapy]] and [[chemotherapy]] are recommended among all patients who develop gliomatosis cerebri. [[Temozolomide]] and [[PCV regimen|PCV 3 combination chemotherapy]] are the preferred drugs for the treatment of high-grade and low-grade gliomatosis cerebri, respectively.<ref name="pmid21301914">{{cite journal| author=Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T| title=Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases. | journal=Neurosurg Rev | year= 2010 | volume= 34 | issue= 2 | pages= 197-208 | pmid=21301914 | doi=10.1007/s10143-010-0306-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21301914  }} </ref><ref name="pmid11708542">{{cite journal| author=Hejazi N, Witzmann A, Hergan K| title=Gliomatosis cerebri: intra vitam stereotactic determination in two cases and review of the literature. | journal=Br J Neurosurg | year= 2001 | volume= 15 | issue= 5 | pages= 396-401 | pmid=11708542 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11708542  }} </ref><ref name="pmid15798516">{{cite journal| author=Sanson M, Napolitano M, Cartalat-Carel S, Taillibert S| title=[Gliomatosis cerebri]. | journal=Rev Neurol (Paris) | year= 2005 | volume= 161 | issue= 2 | pages= 173-81 | pmid=15798516 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15798516  }} </ref> Supportive therapy for gliomatosis cerebri includes [[anticonvulsants]] and [[corticosteroids]].<ref name="pmid22740882">{{cite journal| author=Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR| title=Presentation patterns and outcome of gliomatosis cerebri. | journal=Oncol Lett | year= 2012 | volume= 3 | issue= 1 | pages= 209-213 | pmid=22740882 | doi=10.3892/ol.2011.445 | pmc=PMC3362440 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22740882  }} </ref>
[[Radiotherapy]] and [[chemotherapy]] are recommended among all patients who develop gliomatosis cerebri. [[Temozolomide]] and [[PCV regimen|PCV 3 combination chemotherapy]] are the preferred drugs for the treatment of high-grade and low-grade gliomatosis cerebri, respectivel Supportive therapy for gliomatosis cerebri includes [[anticonvulsants]] and [[corticosteroids]].


==Medical Therapy==
==Medical Therapy==

Latest revision as of 12:19, 25 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Radiotherapy and chemotherapy are recommended among all patients who develop gliomatosis cerebri. Temozolomide and PCV 3 combination chemotherapy are the preferred drugs for the treatment of high-grade and low-grade gliomatosis cerebri, respectivel Supportive therapy for gliomatosis cerebri includes anticonvulsants and corticosteroids.

Medical Therapy

The medical therapy of gliomatosis cerebri includes:

1. Radiotherapy

  • Post-operative radiotherapy is recommended among all patients who develop gliomatosis cerebri.[1]
  • Radiotherapy may not cure the cancer but can control the tumor, delay recurrence, and increase survival.
  • Radiation therapy is associated with temporary improvement of clinical symptoms.[2]
  • External beam radiation therapy is preferred to whole brain radiotherapy.[3]
  • The median dose of radiation is 60 Gy (range: 50-72 Gy).[1]

2. Chemotherapy

3. Supportive treatment

References

  1. 1.0 1.1 Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T (2010). "Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases". Neurosurg Rev. 34 (2): 197–208. doi:10.1007/s10143-010-0306-1. PMID 21301914.
  2. 2.0 2.1 Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR (2012). "Presentation patterns and outcome of gliomatosis cerebri". Oncol Lett. 3 (1): 209–213. doi:10.3892/ol.2011.445. PMC 3362440. PMID 22740882.
  3. Hejazi N, Witzmann A, Hergan K (2001). "Gliomatosis cerebri: intra vitam stereotactic determination in two cases and review of the literature". Br J Neurosurg. 15 (5): 396–401. PMID 11708542.
  4. Levin N, Gomori JM, Siegal T (2004). "Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide". Neurology. 63 (2): 354–6. PMID 15277636.
  5. Lodi R, Setola E, Tonon C, Ambrosetto P, Franceschi E, Crinò L; et al. (2003). "Gliomatosis cerebri: clinical, neurochemical and neuroradiological response to temozolomide administration". Magn Reson Imaging. 21 (9): 1003–7. PMID 14684203.
  6. Sanson M, Napolitano M, Cartalat-Carel S, Taillibert S (2005). "[Gliomatosis cerebri]". Rev Neurol (Paris). 161 (2): 173–81. PMID 15798516.
  7. Levin VA, Edwards MS, Wright DC, Seager ML, Schimberg TP, Townsend JJ; et al. (1980). "Modified procarbazine, CCNU, and vincristine (PCV 3) combination chemotherapy in the treatment of malignant brain tumors". Cancer Treat Rep. 64 (2–3): 237–44. PMID 7407756.
  8. Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB; et al. (2002). "Gliomatosis cerebri: molecular pathology and clinical course". Ann Neurol. 52 (4): 390–9. doi:10.1002/ana.10297. PMID 12325066.
  9. Qaddoumi I, Kocak M, Pai Panandiker AS, Armstrong GT, Wetmore C, Crawford JR; et al. (2014). "Phase II Trial of Erlotinib during and after Radiotherapy in Children with Newly Diagnosed High-Grade Gliomas". Front Oncol. 4: 67. doi:10.3389/fonc.2014.00067. PMC 3978340. PMID 24744992.
  10. Kyritsis AP, Yung WK, Jaeckle KA, Bruner J, Gleason MJ, Ictech SE; et al. (1996). "Combination of 6-thioguanine, procarbazine, lomustine, and hydroxyurea for patients with recurrent malignant gliomas". Neurosurgery. 39 (5): 921–6. PMID 8905746.


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