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{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(i), alpha-1 subunit''' is a [[protein]] that in humans is encoded by the ''GNAI1'' [[gene]].<ref name="pmid3110783">{{cite journal | vauthors = Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M | title = Human cDNA clones for an alpha subunit of Gi signal-transduction protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 15 | pages = 5115–9 | date = Aug 1987 | pmid = 3110783 | pmc = 298804 | doi = 10.1073/pnas.84.15.5115 }}</ref><ref>{{cite web | title = Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2770| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactive pathway map ==
{{GNF_Protein_box
{{NicotineDopaminergicActivity_WP1602|highlight=GNAI1}}
| image = PBB_Protein_GNAI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1agr.
| PDB = {{PDB2|1agr}}, {{PDB2|1as0}}, {{PDB2|1as2}}, {{PDB2|1as3}}, {{PDB2|1bh2}}, {{PDB2|1bof}}, {{PDB2|1cip}}, {{PDB2|1gdd}}, {{PDB2|1gfi}}, {{PDB2|1gg2}}, {{PDB2|1gia}}, {{PDB2|1gil}}, {{PDB2|1git}}, {{PDB2|1gp2}}, {{PDB2|1kjy}}, {{PDB2|1svk}}, {{PDB2|1svs}}, {{PDB2|1y3a}}, {{PDB2|2g83}}, {{PDB2|2gtp}}, {{PDB2|2hlb}}, {{PDB2|2ihb}}, {{PDB2|2ik8}}, {{PDB2|2ode}}
| Name = Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
| HGNCid = 4384
| Symbol = GNAI1
| AltSymbols =; Gi
| OMIM = 139310
| ECnumber = 
| Homologene = 74417
| MGIid = 95771
| GeneAtlas_image1 = PBB_GE_GNAI1_209576_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2770
    | Hs_Ensembl = ENSG00000127955
    | Hs_RefseqProtein = NP_002060
    | Hs_RefseqmRNA = NM_002069
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 79602076
    | Hs_GenLoc_end = 79686655
    | Hs_Uniprot = P63096
    | Mm_EntrezGene = 14677
    | Mm_Ensembl = ENSMUSG00000057614
    | Mm_RefseqmRNA = NM_010305
    | Mm_RefseqProtein = NP_034435
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 17776959
    | Mm_GenLoc_end = 17872237
    | Mm_Uniprot = 
  }}
}}
'''Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1''', also known as '''GNAI1''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2770| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
GNAI1 has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
{{div col|colwidth=20em}}
* [[GPR143]],<ref name = pmid10471510>{{cite journal | vauthors = Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A | title = Ocular albinism: evidence for a defect in an intracellular signal transduction system | journal = Nature Genetics | volume = 23 | issue = 1 | pages = 108–12 | date = Sep 1999 | pmid = 10471510 | doi = 10.1038/12715 }}</ref>
* [[RGS12]],<ref name = pmid11387333/>
* [[RGS14]],<ref name = pmid11387333>{{cite journal | vauthors = Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP | title = RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29275–81 | date = Aug 2001 | pmid = 11387333 | doi = 10.1074/jbc.M103208200 }}</ref><ref name = pmid11976690>{{cite journal | vauthors = Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP | title = Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits | journal = Nature | volume = 416 | issue = 6883 | pages = 878–81 | date = Apr 2002 | pmid = 11976690 | doi = 10.1038/416878a }}</ref>
* [[RGS19]],<ref name = pmid10364213>{{cite journal | vauthors = Woulfe DS, Stadel JM | title = Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP | journal = The Journal of Biological Chemistry | volume = 274 | issue = 25 | pages = 17718–24 | date = Jun 1999 | pmid = 10364213 | doi =  10.1074/jbc.274.25.17718}}</ref><ref name = pmid8986788>{{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 26 | pages = 15203–8 | date = Dec 1996 | pmid = 8986788 | pmc = 26381 | doi =  10.1073/pnas.93.26.15203}}</ref>
* [[RIC8A]],<ref name = pmid12509430>{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8356–62 | date = Mar 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}</ref>  and
* [[S1PR1]].<ref name = pmid8626678>{{cite journal | vauthors = Lee MJ, Evans M, Hla T | title = The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11272–9 | date = May 1996 | pmid = 8626678 | doi =  10.1074/jbc.271.19.11272}}</ref>
{{Div col end}}


==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sidhu A, Niznik HB | title = Coupling of dopamine receptor subtypes to multiple and diverse G proteins | journal = International Journal of Developmental Neuroscience | volume = 18 | issue = 7 | pages = 669–77  | date = Nov 2000 | pmid = 10978845 | doi = 10.1016/S0736-5748(00)00033-2 }}
| citations =
* {{cite journal | vauthors = Brown EJ, Frazier WA | title = Integrin-associated protein (CD47) and its ligands | journal = Trends in Cell Biology | volume = 11 | issue = 3 | pages = 130–5  | date = Mar 2001 | pmid = 11306274 | doi = 10.1016/S0962-8924(00)01906-1 }}
*{{cite journal | author=Sidhu A, Niznik HB |title=Coupling of dopamine receptor subtypes to multiple and diverse G proteins. |journal=Int. J. Dev. Neurosci. |volume=18 |issue= 7 |pages= 669-77 |year= 2000 |pmid= 10978845 |doi= }}
* {{cite journal | vauthors = Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN | title = Multiplicity of mechanisms of serotonin receptor signal transduction | journal = Pharmacology & Therapeutics | volume = 92 | issue = 2-3 | pages = 179–212 | year = 2002 | pmid = 11916537 | doi = 10.1016/S0163-7258(01)00169-3 }}
*{{cite journal | author=Brown EJ, Frazier WA |title=Integrin-associated protein (CD47) and its ligands. |journal=Trends Cell Biol. |volume=11 |issue= 3 |pages= 130-5 |year= 2001 |pmid= 11306274 |doi= }}
* {{cite journal | vauthors = Jiang M, Pandey S, Tran VT, Fong HK | title = Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 9 | pages = 3907–11  | date = May 1991 | pmid = 1902575 | pmc = 51562 | doi = 10.1073/pnas.88.9.3907 }}
*{{cite journal | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi= }}
* {{cite journal | vauthors = Gennity JM, Siess W | title = Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets | journal = The Biochemical Journal | volume = 279 ( Pt 3) | issue = Pt 3 | pages = 643–50  | date = Nov 1991 | pmid = 1953657 | pmc = 1151493 | doi =  }}
*{{cite journal | author=Jiang M, Pandey S, Tran VT, Fong HK |title=Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3907-11 |year= 1991 |pmid= 1902575 |doi= }}
* {{cite journal | vauthors = Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y | title = Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs | journal = The Journal of Biological Chemistry | volume = 263 | issue = 14 | pages = 6656–64  | date = May 1988 | pmid = 2834384 | doi =  }}
*{{cite journal | author=Gennity JM, Siess W |title=Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets. |journal=Biochem. J. |volume=279 ( Pt 3) |issue= |pages= 643-50 |year= 1991 |pmid= 1953657 |doi=  }}
* {{cite journal | vauthors = Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG, Morton CC | title = The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus | journal = American Journal of Human Genetics | volume = 42 | issue = 6 | pages = 884–8  | date = Jun 1988 | pmid = 3130752 | pmc = 1715192 | doi =  }}
*{{cite journal | author=Itoh H, Toyama R, Kozasa T, ''et al.'' |title=Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. |journal=J. Biol. Chem. |volume=263 |issue= 14 |pages= 6656-64 |year= 1988 |pmid= 2834384 |doi=  }}
* {{cite journal | vauthors = Nagata K, Katada T, Tohkin M, Itoh H, Kaziro Y, Ui M, Nozawa Y | title = GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin | journal = FEBS Letters | volume = 237 | issue = 1-2 | pages = 113–7  | date = Sep 1988 | pmid = 3139448 | doi = 10.1016/0014-5793(88)80182-0 }}
*{{cite journal | author=Bray P, Carter A, Guo V, ''et al.'' |title=Human cDNA clones for an alpha subunit of Gi signal-transduction protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 15 |pages= 5115-9 |year= 1987 |pmid= 3110783 |doi=  }}
* {{cite journal | vauthors = Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K, Kozasa T, Imura H, Seino S, Seino Y | title = Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein | journal = Biochemical and Biophysical Research Communications | volume = 202 | issue = 2 | pages = 1188–95  | date = Jul 1994 | pmid = 7914078 | doi = 10.1006/bbrc.1994.2054 }}
*{{cite journal | author=Bloch DB, Bloch KD, Iannuzzi M, ''et al.'' |title=The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus. |journal=Am. J. Hum. Genet. |volume=42 |issue= 6 |pages= 884-8 |year= 1988 |pmid= 3130752 |doi= }}
* {{cite journal | vauthors = Nitta K, Uchida K, Kawashima A, Tsutsui T, Ozu H, Naito T, Yumura W, Nihei H | title = Identification of GTP-binding proteins in human glomeruli | journal = Nihon Jinzo Gakkai Shi | volume = 36 | issue = 1 | pages = 9–12  | date = Jan 1994 | pmid = 8107314 | doi = }}
*{{cite journal | author=Nagata K, Katada T, Tohkin M, ''et al.'' |title=GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin. |journal=FEBS Lett. |volume=237 |issue= 1-2 |pages= 113-7 |year= 1988 |pmid= 3139448 |doi= }}
* {{cite journal | vauthors = Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J, Reisine T | title = Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation | journal = Molecular Pharmacology | volume = 45 | issue = 4 | pages = 587–90  | date = Apr 1994 | pmid = 8183236 | doi =  }}
*{{cite journal | author=Kagimoto S, Yamada Y, Kubota A, ''et al.'' |title=Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 2 |pages= 1188-95 |year= 1994 |pmid= 7914078 |doi= 10.1006/bbrc.1994.2054 }}
* {{cite journal | vauthors = Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A | title = Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy | journal = Endocrinology | volume = 132 | issue = 6 | pages = 2484–90  | date = Jun 1993 | pmid = 8504751 | doi = 10.1210/en.132.6.2484 }}
*{{cite journal | author=Nitta K, Uchida K, Kawashima A, ''et al.'' |title=Identification of GTP-binding proteins in human glomeruli. |journal=Nippon Jinzo Gakkai shi |volume=36 |issue= 1 |pages= 9-12 |year= 1994 |pmid= 8107314 |doi=  }}
* {{cite journal | vauthors = Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G | title = The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 116–20  | date = Jan 1996 | pmid = 8552586 | pmc = 40189 | doi = 10.1073/pnas.93.1.116 }}
*{{cite journal | author=Law SF, Zaina S, Sweet R, ''et al.'' |title=Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation. |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 587-90 |year= 1994 |pmid= 8183236 |doi= }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13  | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A |title=Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. |journal=Endocrinology |volume=132 |issue= 6 |pages= 2484-90 |year= 1993 |pmid= 8504751 |doi= }}
* {{cite journal | vauthors = Lee MJ, Evans M, Hla T | title = The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11272–9  | date = May 1996 | pmid = 8626678 | doi = 10.1074/jbc.271.19.11272 }}
*{{cite journal | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116-20 |year= 1996 |pmid= 8552586 |doi= }}
* {{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 26 | pages = 15203–8 | year = 1997 | date = Dec 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8  | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Lee MJ, Evans M, Hla T |title=The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11272-9 |year= 1996 |pmid= 8626678 |doi= }}
* {{cite journal | vauthors = Popov S, Yu K, Kozasa T, Wilkie TM | title = The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 14 | pages = 7216–20  | date = Jul 1997 | pmid = 9207071 | pmc = 23796 | doi = 10.1073/pnas.94.14.7216 }}
*{{cite journal | author=De Vries L, Elenko E, Hubler L, ''et al.'' |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203-8 |year= 1997 |pmid= 8986788 |doi= }}
* {{cite journal | vauthors = Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI | title = RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells | journal = Journal of Neurochemistry | volume = 70 | issue = 5 | pages = 1964–72  | date = May 1998 | pmid = 9572280 | doi = 10.1046/j.1471-4159.1998.70051964.x }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal | author=Popov S, Yu K, Kozasa T, Wilkie TM |title=The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7216-20 |year= 1997 |pmid= 9207071 |doi= }}
*{{cite journal  | author=Shuey DJ, Betty M, Jones PG, ''et al.'' |title=RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells. |journal=J. Neurochem. |volume=70 |issue= 5 |pages= 1964-72 |year= 1998 |pmid= 9572280 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Intracellular signaling peptides and proteins}}
{{PDB Gallery|geneid=2770}}
 
{{GTPases}}
{{GTPases}}
{{WikiDoc Sources}}

Latest revision as of 08:50, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.[1][2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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<imagemap> Image:NicotineDopaminergic_WP1602.png
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNAI1 has been shown to interact with:

References

  1. ↑ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.
  2. ↑ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".
  3. ↑ Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics. 23 (1): 108–12. doi:10.1038/12715. PMID 10471510.
  4. ↑ 4.0 4.1 Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
  5. ↑ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690.
  6. ↑ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
  7. ↑ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
  8. ↑ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  9. ↑ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=GNAI1&oldid=1422035"