Epilepsy laboratory findings: Difference between revisions
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__NOTOC__ | |||
{{Epilepsy}} | {{Epilepsy}} | ||
{{CMG}} {{AE}} {{ | {{CMG}} {{AE}} {{Fs}} | ||
== Overview == | |||
Laboratory findings consistent with the diagnosis of epilepsy include: Elevated [[creatine phosphokinase]] (CPK), elevated [[cortisol]], elevated [[white blood cell count]], elevated [[lactate dehydrogenase]] and elevated [[neuron-specific enolase]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
* Laboratory findings consistent with the diagnosis of a seizure attack include:<ref name="pmid15080857">{{cite journal |vauthors=Willert C, Spitzer C, Kusserow S, Runge U |title=Serum neuron-specific enolase, prolactin, and creatine kinase after epileptic and psychogenic non-epileptic seizures |journal=Acta Neurol. Scand. |volume=109 |issue=5 |pages=318–23 |date=May 2004 |pmid=15080857 |doi=10.1046/j.1600-0404.2003.00232.x |url=}}</ref><ref name="pmid4037754">{{cite journal |vauthors=Pritchard PB, Wannamaker BB, Sagel J, Daniel CM |title=Serum prolactin and cortisol levels in evaluation of pseudoepileptic seizures |journal=Ann. Neurol. |volume=18 |issue=1 |pages=87–9 |date=July 1985 |pmid=4037754 |doi=10.1002/ana.410180115 |url=}}</ref> | * Laboratory findings consistent with the diagnosis of a [[seizure]] attack include:<ref name="pmid15080857">{{cite journal |vauthors=Willert C, Spitzer C, Kusserow S, Runge U |title=Serum neuron-specific enolase, prolactin, and creatine kinase after epileptic and psychogenic non-epileptic seizures |journal=Acta Neurol. Scand. |volume=109 |issue=5 |pages=318–23 |date=May 2004 |pmid=15080857 |doi=10.1046/j.1600-0404.2003.00232.x |url=}}</ref><ref name="pmid4037754">{{cite journal |vauthors=Pritchard PB, Wannamaker BB, Sagel J, Daniel CM |title=Serum prolactin and cortisol levels in evaluation of pseudoepileptic seizures |journal=Ann. Neurol. |volume=18 |issue=1 |pages=87–9 |date=July 1985 |pmid=4037754 |doi=10.1002/ana.410180115 |url=}}</ref> | ||
** Elevated creatine phosphokinase (CPK) | ** Elevated [[creatine phosphokinase]] (CPK) | ||
** Elevated cortisol | ** Elevated [[cortisol]] | ||
** Elevated white blood cell count | ** Elevated [[white blood cell count]] | ||
** Elevated lactate dehydrogenase | ** Elevated [[lactate dehydrogenase]] | ||
** Elevated neuron-specific enolase | ** Elevated [[neuron-specific enolase]] | ||
* For the first seizure episode, in order to find the etiology we should test for:<ref name="pmid18025394">{{cite journal |vauthors=Krumholz A, Wiebe S, Gronseth G, Shinnar S, Levisohn P, Ting T, Hopp J, Shafer P, Morris H, Seiden L, Barkley G, French J |title=Practice Parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society |journal=Neurology |volume=69 |issue=21 |pages=1996–2007 |date=November 2007 |pmid=18025394 |doi=10.1212/01.wnl.0000285084.93652.43 |url=}}</ref> | * For the first [[seizure]] episode, in order to find the etiology we should test for:<ref name="pmid18025394">{{cite journal |vauthors=Krumholz A, Wiebe S, Gronseth G, Shinnar S, Levisohn P, Ting T, Hopp J, Shafer P, Morris H, Seiden L, Barkley G, French J |title=Practice Parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society |journal=Neurology |volume=69 |issue=21 |pages=1996–2007 |date=November 2007 |pmid=18025394 |doi=10.1212/01.wnl.0000285084.93652.43 |url=}}</ref> | ||
** Electrolytes | ** [[Electrolyte|Electrolytes]] | ||
** Glucose | ** [[Glucose]] | ||
** Calcium | ** [[Calcium]] | ||
** Magnesium | ** [[Magnesium]] | ||
** Complete blood count | ** [[Complete blood count]] | ||
** Renal function tests | ** [[Renal function tests]] | ||
** Liver function tests | ** [[Liver function tests]] | ||
** Urinalysis | ** [[Urinalysis]] | ||
** Toxicology screens | ** [[Toxicology]] screens | ||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Needs overview]] | [[Category:Needs overview]] | ||
[[Category:Neurological disorders]] | [[Category:Neurological disorders]] | ||
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[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
Latest revision as of 21:37, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
Laboratory findings consistent with the diagnosis of epilepsy include: Elevated creatine phosphokinase (CPK), elevated cortisol, elevated white blood cell count, elevated lactate dehydrogenase and elevated neuron-specific enolase.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of a seizure attack include:[1][2]
- Elevated creatine phosphokinase (CPK)
- Elevated cortisol
- Elevated white blood cell count
- Elevated lactate dehydrogenase
- Elevated neuron-specific enolase
- For the first seizure episode, in order to find the etiology we should test for:[3]
References
- ↑ Willert C, Spitzer C, Kusserow S, Runge U (May 2004). "Serum neuron-specific enolase, prolactin, and creatine kinase after epileptic and psychogenic non-epileptic seizures". Acta Neurol. Scand. 109 (5): 318–23. doi:10.1046/j.1600-0404.2003.00232.x. PMID 15080857.
- ↑ Pritchard PB, Wannamaker BB, Sagel J, Daniel CM (July 1985). "Serum prolactin and cortisol levels in evaluation of pseudoepileptic seizures". Ann. Neurol. 18 (1): 87–9. doi:10.1002/ana.410180115. PMID 4037754.
- ↑ Krumholz A, Wiebe S, Gronseth G, Shinnar S, Levisohn P, Ting T, Hopp J, Shafer P, Morris H, Seiden L, Barkley G, French J (November 2007). "Practice Parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society". Neurology. 69 (21): 1996–2007. doi:10.1212/01.wnl.0000285084.93652.43. PMID 18025394.