Differentiating urticaria from other diseases: Difference between revisions

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==Differentiating Urticaria from other Diseases==
==Differentiating Urticaria from other Diseases==
* Hereditary or acquired deficiency of complement factor C1
*[[Complement deficiency|Hereditary or acquired deficiency of complement factor C1]]
* Cutaneous [[mastocytosis]]/urticaria pigmentosa  
*[[mast cell tumor|Cutaneous mastocytosis]]/[[urticaria pigmentosa]]
* [[Malignancy]]
*[[Malignancy]]
* Poison ivy contact dermatitis: The rash that develops from poison ivy, poison oak, and poison sumac contact are commonly mistaken for urticaria. This rash is caused by contact with [[urushiol]] and results in a form of [[contact dermatitis]] called [[Urushiol-induced contact dermatitis]]. Urushiol is spread by contact but can be washed off with a strong grease/oil dissolving detergent and cool water.
*[[Connective tissue diseases]]
* [[Angioedema]]: It is related to urticaria.  In angioedema, the swelling occurs in a lower layer of the dermis than it does in urticaria.<ref>{{cite web | url = http://www.webmd.com/allergies/guide/hives-urticaria-angioedema | title = Hives (Urticaria and Angioedema) | date = 2006-03-01 | accessdate = 2007-08-24}}</ref>  This swelling can occur around the mouth, in the throat, in the abdomen, or in other locations. Urticaria and angioedema sometimes occur together in response to an [[allergen]] and is a concern in severe cases because angioedema of the throat can be fatal.
*photosensitive diseases
*[[Urushiol-induced contact dermatitis|Poison ivy contact dermatitis]]: The rash that develops from [[Urushiol-induced contact dermatitis|poison ivy, poison oak, and poison sumac contact]] are commonly mistaken for [[urticaria]]. This [[rash]] is caused by contact with [[urushiol]] and results in a form of [[contact dermatitis]] called [[Urushiol-induced contact dermatitis]].  
*[[Angioedema]]:  
**Although it might be related to [[urticaria]], [[angioedema]] occur due to the swelling of lower layers of the [[dermis]].<ref>{{cite web | url = http://www.webmd.com/allergies/guide/hives-urticaria-angioedema | title = Hives (Urticaria and Angioedema) | date = 2006-03-01 | accessdate = 2007-08-24}}</ref>   
**[[Edema]] can occur around the [[mouth]], in the [[throat]], in the [[abdomen]], or in other locations. [[Urticaria]] and [[angioedema]] sometimes occur together in response to an [[allergen]] and is a concern in severe cases because [[angioedema]] of the [[throat]] can be fatal.
*A possible [[differential diagnosis]] for diseases that cause [[urticaria]], and [[rash]] include:
*A possible [[differential diagnosis]] for diseases that cause [[urticaria]], and [[rash]] include:
**Cold Contact Urticaria
**[[Schnitzler Syndrome]]
**Schnitzler Syndrome
**Deficiency in [[Interleukin 1 receptor antagonist|interleukin-1 receptor antagonist]]
**Deficiency in Interleukin-1 Receptor Antagonist
**[[Juvenile idiopathic arthritis]]
**Systemic-Onset Juvenile Idiopathic Arthritis
**[[Adult-onset Still’s disease]]
**Adult-Onset Still’s Disease
**[[virus|Viral]] [[rashes]]
*Table below differentiates the aforementioned [[conditions]]:
*Table below differentiates some of the aforementioned [[conditions]]:
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* May cause destructive [[arthritis]]
* May cause destructive [[arthritis]]
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 19:41, 23 December 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Differentiating Urticaria from other Diseases

Disease name Age of onset Signs/Symptoms Diagnostic feature(s) Other features
Cold Contact Urticaria[2][3]
  • Early adulthood
  • Urticarial skin eruption after exposure to cold
  • Urticaria and/or angioedema affects areas only in contact with cold
  • Systemic symptoms may be present in case of extensive skin involvement (even anaphylaxis)
  • Ice cube test is positive
  • The wheal appears within 5 minutes of cold contact
Familial Cold Autoinflammatory Syndrome[4]
  • Infancy, but may be delayed until adulthood


  • Ice cube test is negative
Schnitzler Syndrome[5]
Deficiency in Interleukin-1 Receptor Antagonist[6]
Systemic-Onset Juvenile Idiopathic Arthritis[7]
  • 2-16 years of age
Adult-Onset Still’s Disease[8]
  • 16-35 years
  • May affect all ages
  • More commonly seen among women
  • May cause destructive arthritis

References

  1. "Hives (Urticaria and Angioedema)". 2006-03-01. Retrieved 2007-08-24.
  2. Siebenhaar, F.; Weller, K.; Mlynek, A.; Magerl, M.; Altrichter, S.; Vieira dos Santos, R.; Maurer, M.; Zuberbier, T. (2007). "Acquired cold urticaria: clinical picture and update on diagnosis and treatment". Clinical and Experimental Dermatology. 32 (3): 241–245. doi:10.1111/j.1365-2230.2007.02376.x. ISSN 0307-6938.
  3. Krause, Karoline; Zuberbier, Torsten; Maurer, Marcus (2010). "Modern Approaches to the Diagnosis and Treatment of Cold Contact Urticaria". Current Allergy and Asthma Reports. 10 (4): 243–249. doi:10.1007/s11882-010-0121-3. ISSN 1529-7322.
  4. Kastner, D. L. (2005). "Hereditary Periodic Fever Syndromes". Hematology. 2005 (1): 74–81. doi:10.1182/asheducation-2005.1.74. ISSN 1520-4391.
  5. de Koning, Heleen D.; Bodar, Evelien J.; van der Meer, Jos W.M.; Simon, Anna (2007). "Schnitzler Syndrome: Beyond the Case Reports: Review and Follow-Up of 94 Patients with an Emphasis on Prognosis and Treatment". Seminars in Arthritis and Rheumatism. 37 (3): 137–148. doi:10.1016/j.semarthrit.2007.04.001. ISSN 0049-0172.
  6. Aksentijevich, Ivona; Masters, Seth L.; Ferguson, Polly J.; Dancey, Paul; Frenkel, Joost; van Royen-Kerkhoff, Annet; Laxer, Ron; Tedgård, Ulf; Cowen, Edward W.; Pham, Tuyet-Hang; Booty, Matthew; Estes, Jacob D.; Sandler, Netanya G.; Plass, Nicole; Stone, Deborah L.; Turner, Maria L.; Hill, Suvimol; Butman, John A.; Schneider, Rayfel; Babyn, Paul; El-Shanti, Hatem I.; Pope, Elena; Barron, Karyl; Bing, Xinyu; Laurence, Arian; Lee, Chyi-Chia R.; Chapelle, Dawn; Clarke, Gillian I.; Ohson, Kamal; Nicholson, Marc; Gadina, Massimo; Yang, Barbara; Korman, Benjamin D.; Gregersen, Peter K.; van Hagen, P. Martin; Hak, A. Elisabeth; Huizing, Marjan; Rahman, Proton; Douek, Daniel C.; Remmers, Elaine F.; Kastner, Daniel L.; Goldbach-Mansky, Raphaela (2009). "An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist". New England Journal of Medicine. 360 (23): 2426–2437. doi:10.1056/NEJMoa0807865. ISSN 0028-4793.
  7. Gurion, R.; Lehman, T. J. A.; Moorthy, L. N. (2012). "Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment". International Journal of Inflammation. 2012: 1–16. doi:10.1155/2012/271569. ISSN 2090-8040.
  8. Efthimiou, P (2006). "Diagnosis and management of adult onset Still's disease". Annals of the Rheumatic Diseases. 65 (5): 564–572. doi:10.1136/ard.2005.042143. ISSN 0003-4967.

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