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==Overview==
==Overview==
[[William Osler|Sir William Osler]], known as "the father of modern medicine," appreciated the morbidity and mortality of pneumonia, describing it as the "captain of the men of death" in 1918. However, several key developments in the 1900s improved the outcome for those with pneumonia. With the advent of [[penicillin]] and other antibiotics, modern surgical techniques, and intensive care in the twentieth century, mortality from pneumonia dropped precipitously in the developed world. Vaccination of infants against ''[[Haemophilus influenzae]]'' type b began in 1988 and led to a dramatic decline in cases shortly thereafter.<ref name=adams>Adams WG, Deaver KA, Cochi SL, et al. Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era.''JAMA''1993;269:221-6. PMID 8417239</ref> Vaccination against ''[[Streptococcus pneumoniae|Streptococcus pneumoniae]]'' in adults began in 1977 and in children it began in 2000, resulting in a similar decline.<ref name=whit>Whitney CG, Farley MM, Hadler J, et al. Decline in invasive pneumococcal disease after the introduction of pneumococcal protein-polysaccharide conjugate vaccine.'' New Engl J Med''. 2003;348:1737–1746. PMID 12724479</ref>
 
[[William Osler|Sir William Osler]], known as "the Father of Modern Medicine," appreciated the morbidity and mortality of [[pneumonia]], describing it as the "Captain of the Men of Death" in 1918. However, several key developments in the 1900s improved the outcome for those with pneumonia. With the arrival of: [[penicillin]] and other antibiotics; modern surgical techniques; and intensive care in the twentieth century, mortality from [[pneumonia]] dropped precipitously in the developed world. [[Vaccination]] of infants against ''[[Haemophilus influenzae]]'' type b began in 1988 and led to a dramatic decline in cases shortly thereafter.<ref name=adams>Adams WG, Deaver KA, Cochi SL, et al. Decline of childhood ''[[Haemophilus influenzae]]'' type b (Hib) disease in the Hib vaccine era.''JAMA''1993;269:221-6. PMID 8417239</ref> Vaccination against ''[[Streptococcus pneumoniae|Streptococcus pneumoniae]]'' in adults began in 1977, and it began in children in 2000, resulting in a similar decline.<ref name=whit>Whitney CG, Farley MM, Hadler J, et al. Decline in invasive pneumococcal disease after the introduction of pneumococcal protein-polysaccharide conjugate vaccine.'' New Engl J Med''. 2003;348:1737–1746. PMID 12724479</ref>


==Historical Perspective==
==Historical Perspective==
The symptoms of pneumonia were described by [[Hippocrates]] (c. 460 BC–380 BC) as:
 
The symptoms of [[pneumonia]] were described by [[Hippocrates]] (c. 460 BC–380 BC) as:
{{cquote|
{{cquote|
Peripneumonia, and pleuritic affections, are to be thus observed: If the fever be acute, and if there be pains on either side, or in both, and if expiration be if cough be present, and the sputa expectorated be of a blond or livid color, or likewise thin, frothy, and florid, or having any other character different from the common... When pneumonia is at its height, the case is beyond remedy if he is not purged, and it is bad if he has dyspnoea, and urine that is thin and acrid, and if sweats come out about the neck and head, for such sweats are bad, as proceeding from the suffocation, rales, and the violence of the disease which is obtaining the upper hand.''}}
Peripneumonia, and pleuritic affections, are to be thus observed: If the fever be acute, and if there be pains on either side, or in both, and if expiration be if cough be present, and the sputa expectorated be of a blond or livid color, or likewise thin, frothy, and florid, or having any other character different from the common... When pneumonia is at its height, the case is beyond remedy if he is not purged, and it is bad if he has dyspnoea, and urine that is thin and acrid, and if sweats come out about the neck and head, for such sweats are bad, as proceeding from the suffocation, rales, and the violence of the disease which is obtaining the upper hand.''}}


However, Hippocrates himself referred to pneumonia as a disease "named by the ancients." He also reported the results of surgical drainage of empyemas. Maimonides (1138–1204 AD) observed "The basic symptoms which occur in pneumonia and which are never lacking are as follows: acute fever, sticking [[pleuritic pain]] in the side, short rapid breaths, serrated pulse and cough."<ref name=maimo>Maimonides, ''Fusul Musa'' ("''Pirkei Moshe''").</ref> This clinical description is quite similar to those found in modern textbooks, and it reflected the extent of medical knowledge through the Middle Ages into the 19th century.
However, [[Hippocrates]] himself referred to pneumonia as a disease "named by the ancients." He also reported the results of surgical drainage of [[empyema]]s. Maimonides (1138–1204 AD) observed "The basic symptoms which occur in [[pneumonia]] and which are never lacking are as follows: acute fever, sticking [[pleuritic pain]] in the side, short rapid breaths, serrated pulse and cough."<ref name=maimo>Maimonides, ''Fusul Musa'' ("''Pirkei Moshe''").</ref> This clinical description is quite similar to those found in modern textbooks, and it reflects the extent of medical knowledge during the Middle Ages into the 19th century.


Bacteria was first seen in the airways of individuals who died from pneumonia by [[Edwin Klebs]] in 1875.<ref name=klebs>Klebs E. Beiträge zur Kenntniss der pathogenen Schistomyceten. VII Die Monadinen. ''Arch. exptl. Pathol. Parmakol.'' 1875 Dec 10;4(5/6):40–488.</ref> Initial work identifying the two common bacterial causes ''Streptococcus pneumoniae'' and ''Klebsiella pneumoniae'' was performed by [[Carl Friedländer]]<ref name=fried>Friedländer C. Über die Schizomyceten bei der acuten fibrösen Pneumonie.'' Virchow's Arch pathol. Anat. u. Physiol.'' 1882 Feb 4;87(2):319–324.</ref> and Albert Fränkel (1848-1916)<ref name=fraenkel>Fraenkel A. Über die genuine Pneumonie, Verhandlungen des Congress für innere Medicin. ''Dritter Congress''. 1884 April 21;3:17–31.</ref> in 1882 and 1884, respectively. Friedländer's initial work introduced the [[Gram staining|Gram stain]], a fundamental laboratory test still used to identify and categorize bacteria. Christian Gram's paper describing the procedure in 1884 helped differentiate the two different bacteria and showed that pneumonia could be caused by more than one microorganism.<ref name=gram>Gram C. Über die isolierte Färbung der Schizomyceten in Schnitt- und Trocken-präparaten.'' Fortschr. Med''. 1884 March 15;2(6):185–189.</ref>
[[Edwin Klebs]] was the first to see Bacteria in the airways of individuals who died from [[pneumonia]] in 1875.<ref name=klebs>Klebs E. Beiträge zur Kenntniss der pathogenen Schistomyceten. VII Die Monadinen. ''Arch. exptl. Pathol. Parmakol.'' 1875 Dec 10;4(5/6):40–488.</ref> Initial work performed by [[Carl Friedländer]]<ref name=fried>Friedländer C. Über die Schizomyceten bei der acuten fibrösen Pneumonie.'' Virchow's Arch pathol. Anat. u. Physiol.'' 1882 Feb 4;87(2):319–324.</ref> and Albert Fränkel (1848-1916)<ref name=fraenkel>Fraenkel A. Über die genuine Pneumonie, Verhandlungen des Congress für innere Medicin. ''Dritter Congress''. 1884 April 21;3:17–31.</ref> in 1882 and 1884, respectively, identified the two common bacterial causes ''Streptococcus pneumoniae'' and ''Klebsiella pneumoniae''. Friedländer's initial work introduced the [[Gram staining|Gram stain]], a fundamental laboratory test still used to identify and categorize bacteria. [[Hans Christian Gram|Christian Gram]]'s paper describing the procedure in 1884 helped differentiate the two different bacteria and showed that pneumonia can be caused by more than one microorganism.<ref name=gram>Gram C. Über die isolierte Färbung der Schizomyceten in Schnitt- und Trocken-präparaten.'' Fortschr. Med''. 1884 March 15;2(6):185–189.</ref>


===Early Classification Schemes===
===Early Classification Schemes===


Pneumonias can be classified in several ways. Pathologists originally classified them according to the [[anatomy|anatomic]] changes that were found in the lungs during [[autopsy|autopsies]]. As more became known about the microorganisms causing pneumonia, a [[microbiology|microbiologic]] classification arose, and with the advent of [[x-ray]]s, a [[radiology|radiological]] classification was created as well. Another important system of classification is the combined clinical classification, which combines factors such as age, risk factors for certain microorganisms, the presence of underlying lung disease and underlying systemic disease, and whether the person has recently been hospitalized.
Pneumonia can be classified in several ways. Pathologists originally classified the different forms according to the [[anatomy|anatomic]] changes that were found in the lungs during [[autopsy|autopsies]]. As more became known about the microorganisms causing [[pneumonia]], a [[microbiology|microbiologic]] classification arose, and with the advent of [[x-ray]]s, a [[radiology|radiological]] classification was created as well. Another important system of classification is the combined clinical classification, which combines factors such as: age, risk factors for certain microorganisms, the presence of underlying lung disease and underlying systemic disease, and whether or not the person has recently been hospitalized.
 
Initial descriptions of pneumonia focused on the anatomic or [[pathology|pathologic]] appearance of the lung, either by direct inspection during [[autopsy]] or by its appearance under a [[microscope]].  


Initial descriptions of pneumonia focused on the anatomic or [[pathology|pathologic]] appearance of the lung, either by direct inspection at [[autopsy]] or by its appearance under a [[microscope]]. A ''lobar'' pneumonia is an infection that only involves a single lobe, or section, of a [[lung]]. Lobar pneumonia is often due to ''[[Streptococcus pneumoniae]]''. ''Multilobar'' pneumonia involves more than one lobe, and it often causes a more severe illness. ''Interstitial'' pneumonia involves the areas in between the [[alveoli]], and it may be called "interstitial pneumonitis." It is more likely to be caused by viruses or by atypical bacteria. The discovery of x-rays made it possible to determine the anatomic type of pneumonia without direct examination of the lungs at autopsy and led to the development of a [[radiology|radiological]] classification. Early investigators distinguished between typical lobar pneumonia and atypical (e.g. Chlamydophila) or [[viral pneumonia]] using the location, distribution, and the appearance of the opacities they saw on chest x-rays. Certain x-ray findings can be used to help predict the course of illness, although it is not possible to clearly determine the microbiologic cause of a pneumonia with x-rays alone.
* ''Lobar pneumonia'' is an infection that only involves a single lobe, or section, of a [[lung]]. Lobar pneumonia is often due to ''[[Streptococcus pneumoniae]]''.
 
* ''Multilobar pneumonia'' involves more than one lobe, and it often causes a more severe illness.  
 
* ''Interstitial pneumonia'' involves the areas in between the [[alveoli]], and it may be called "[[interstitial pneumonitis]]". It is more likely to be caused by viruses or by atypical bacteria.  
 
The discovery of x-rays made it possible to determine the anatomic type of pneumonia without direct examination of the lungs during autopsy; this led to the development of a [[radiology|radiological]] classification. Early investigators distinguished between typical lobar pneumonia and atypical (e.g. [[Chlamydophila]]) or [[viral pneumonia]] using the location, distribution, and the appearance of the opacities they saw on chest X-rays. Certain X-ray findings can be used to help predict the course of illness, although it is not possible to clearly determine the microbiologic cause of a [[pneumonia]] with X-rays alone.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Needs content]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Infectious disease]]
[[Category:Pneumonia|Pneumonia]]
[[Category:Pneumonia|Pneumonia]]
[[Category:Emergency medicine]]
[[Category:Emergency medicine]]
[[Category:primary care]]

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Sir William Osler, known as "the Father of Modern Medicine," appreciated the morbidity and mortality of pneumonia, describing it as the "Captain of the Men of Death" in 1918. However, several key developments in the 1900s improved the outcome for those with pneumonia. With the arrival of: penicillin and other antibiotics; modern surgical techniques; and intensive care in the twentieth century, mortality from pneumonia dropped precipitously in the developed world. Vaccination of infants against Haemophilus influenzae type b began in 1988 and led to a dramatic decline in cases shortly thereafter.[1] Vaccination against Streptococcus pneumoniae in adults began in 1977, and it began in children in 2000, resulting in a similar decline.[2]

Historical Perspective

The symptoms of pneumonia were described by Hippocrates (c. 460 BC–380 BC) as:

Peripneumonia, and pleuritic affections, are to be thus observed: If the fever be acute, and if there be pains on either side, or in both, and if expiration be if cough be present, and the sputa expectorated be of a blond or livid color, or likewise thin, frothy, and florid, or having any other character different from the common... When pneumonia is at its height, the case is beyond remedy if he is not purged, and it is bad if he has dyspnoea, and urine that is thin and acrid, and if sweats come out about the neck and head, for such sweats are bad, as proceeding from the suffocation, rales, and the violence of the disease which is obtaining the upper hand.

However, Hippocrates himself referred to pneumonia as a disease "named by the ancients." He also reported the results of surgical drainage of empyemas. Maimonides (1138–1204 AD) observed "The basic symptoms which occur in pneumonia and which are never lacking are as follows: acute fever, sticking pleuritic pain in the side, short rapid breaths, serrated pulse and cough."[3] This clinical description is quite similar to those found in modern textbooks, and it reflects the extent of medical knowledge during the Middle Ages into the 19th century.

Edwin Klebs was the first to see Bacteria in the airways of individuals who died from pneumonia in 1875.[4] Initial work performed by Carl Friedländer[5] and Albert Fränkel (1848-1916)[6] in 1882 and 1884, respectively, identified the two common bacterial causes Streptococcus pneumoniae and Klebsiella pneumoniae. Friedländer's initial work introduced the Gram stain, a fundamental laboratory test still used to identify and categorize bacteria. Christian Gram's paper describing the procedure in 1884 helped differentiate the two different bacteria and showed that pneumonia can be caused by more than one microorganism.[7]

Early Classification Schemes

Pneumonia can be classified in several ways. Pathologists originally classified the different forms according to the anatomic changes that were found in the lungs during autopsies. As more became known about the microorganisms causing pneumonia, a microbiologic classification arose, and with the advent of x-rays, a radiological classification was created as well. Another important system of classification is the combined clinical classification, which combines factors such as: age, risk factors for certain microorganisms, the presence of underlying lung disease and underlying systemic disease, and whether or not the person has recently been hospitalized.

Initial descriptions of pneumonia focused on the anatomic or pathologic appearance of the lung, either by direct inspection during autopsy or by its appearance under a microscope.

  • Lobar pneumonia is an infection that only involves a single lobe, or section, of a lung. Lobar pneumonia is often due to Streptococcus pneumoniae.
  • Multilobar pneumonia involves more than one lobe, and it often causes a more severe illness.
  • Interstitial pneumonia involves the areas in between the alveoli, and it may be called "interstitial pneumonitis". It is more likely to be caused by viruses or by atypical bacteria.

The discovery of x-rays made it possible to determine the anatomic type of pneumonia without direct examination of the lungs during autopsy; this led to the development of a radiological classification. Early investigators distinguished between typical lobar pneumonia and atypical (e.g. Chlamydophila) or viral pneumonia using the location, distribution, and the appearance of the opacities they saw on chest X-rays. Certain X-ray findings can be used to help predict the course of illness, although it is not possible to clearly determine the microbiologic cause of a pneumonia with X-rays alone.

References

  1. Adams WG, Deaver KA, Cochi SL, et al. Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era.JAMA1993;269:221-6. PMID 8417239
  2. Whitney CG, Farley MM, Hadler J, et al. Decline in invasive pneumococcal disease after the introduction of pneumococcal protein-polysaccharide conjugate vaccine. New Engl J Med. 2003;348:1737–1746. PMID 12724479
  3. Maimonides, Fusul Musa ("Pirkei Moshe").
  4. Klebs E. Beiträge zur Kenntniss der pathogenen Schistomyceten. VII Die Monadinen. Arch. exptl. Pathol. Parmakol. 1875 Dec 10;4(5/6):40–488.
  5. Friedländer C. Über die Schizomyceten bei der acuten fibrösen Pneumonie. Virchow's Arch pathol. Anat. u. Physiol. 1882 Feb 4;87(2):319–324.
  6. Fraenkel A. Über die genuine Pneumonie, Verhandlungen des Congress für innere Medicin. Dritter Congress. 1884 April 21;3:17–31.
  7. Gram C. Über die isolierte Färbung der Schizomyceten in Schnitt- und Trocken-präparaten. Fortschr. Med. 1884 March 15;2(6):185–189.