Colorectal cancer surgery: Difference between revisions

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__NOTOC__
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{{Colon cancer}}
{{Colon cancer}}
'''Editor(s)-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:charlesmichaelgibson@gmail.com]  Phone:617-632-7753; Elliot B. Tapper, M.D., Beth Israel Deaconess Medical Center
To view the surgery of familial adenomatous polyposis (FAP), click [[Familial adenomatous polyposis surgery|'''here''']]<br>
To view the surgery of hereditary nonpolyposis colorectal cancer (HNPCC), click [[Hereditary nonpolyposis colorectal cancer surgery|'''here''']]<br><br>
{{CMG}} {{AE}} Elliot B. Tapper, M.D., Saarah T. Alkhairy, M.D.


==Overview==
==Overview==
Surgery remains the primary treatment while chemotherapy and/or radiotherapy may be recommended depending on the individual patient's staging and other medical factors.
Surgery remains the primary treatment while chemotherapy and/or radiotherapy may be recommended depending on the individual patient's staging and other medical factors.


==Surgery==
==Colorectal Cancer Surgery==


Surgeries can be categorised into curative, palliative, bypass, fecal diversion, or open-and-close.
Surgeries can be categorized into curative, palliative, bypass, open-and-close, or laparoscopic surgical treatment.


'''Curative''' [[Surgery|Surgical]] treatment can be offered if the tumor is localized.  
===Curative Surgical Treatment===
* Very early cancer that develops within a [[polyp]] can often be cured by removing the polyp (i.e., polypectomy) at the time of [[colonoscopy]].  
*This surgical treatment can be offered if the tumor is localized.
* In colon cancer, a more advanced tumor typically requires surgical removal of the section of colon containing the tumor with sufficient margins, and radical en-bloc resection of [[mesentery]] and [[lymph node]]s to reduce local recurrence (i.e., colectomy). If possible, the remaining parts of colon are [[anastomosis|anastomosed]] together to create a functioning colon. In cases when anastomosis is not possible, a [[stoma (medicine)|stoma]] (artificial orifice) is created.  
*Very early cancer that develops within a [[polyp]] can often be cured by removing the polyp (i.e., polypectomy) at the time of [[colonoscopy]].  
* Curative surgery on rectal cancer includes [[total mesorectal excision]] ([[lower anterior resection]]) or [[abdominoperineal excision]].
*In colon cancer, a more advanced tumor typically requires surgical removal of the section of colon (i.e., colectomy) containing the tumor with sufficient margins, and radical en-bloc resection of [[mesentery]] and [[lymph node]]s to reduce local recurrence.
:*If possible, the remaining parts of colon are [[anastomosis|anastomosed]] together to create a functioning colon, otherwise a [[stoma (medicine)|stoma]] is created.
*Curative surgery on rectal cancer includes [[total mesorectal excision]] ([[lower anterior resection]]) or [[abdominoperineal excision]].<ref name="pmid26298899">{{cite journal| author=Peschaud F| title=[Surgical treatment of colorectal cancer]. | journal=Rev Prat | year= 2015 | volume= 65 | issue= 6 | pages= 779-83 | pmid=26298899 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26298899  }}</ref>


In case of multiple metastases, '''palliative''' (non curative) [[resection]] of the primary tumor is still offered in order to reduce further [[morbidity]] caused by tumor bleeding, invasion, and its catabolic effect. Surgical removal of isolated liver metastases is, however, common and may be curative in selected patients; improved [[chemotherapy]] has increased the number of patients who are offered surgical removal of isolated liver metastases.  
===Palliative Surgical Treatment===
*In case of multiple metastases, a palliative [[resection]] of the primary tumor is still offered to reduce further [[morbidity]].  
*Surgical removal of isolated liver metastases is common and may be curative<ref name="pmid20729045">{{cite journal| author=McCullough JA, Engledow AH| title=Treatment options in obstructed left-sided colonic cancer. | journal=Clin Oncol (R Coll Radiol) | year= 2010 | volume= 22 | issue= 9 | pages= 764-70 | pmid=20729045 | doi=10.1016/j.clon.2010.07.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20729045  }}</ref> 


If the tumor invaded into adjacent vital structures which makes [[excision]] technically difficult, the surgeons may prefer to '''bypass''' the tumor (ileotransverse bypass) or to do a proximal '''fecal diversion''' through a [[stoma (medicine)|stoma]].
===Bypass Surgical Treatment===
*If the tumor invaded adjacent vital structures which makes [[excision]] technically difficult, surgeons may prefer to bypass the tumor (ileotransverse bypass) or to do a proximal fecal diversion through a [[stoma (medicine)|stoma]].<ref name="pmid7522123">{{cite journal| author=McGinnis LS| title=Surgical treatment options for colorectal cancer. | journal=Cancer | year= 1994 | volume= 74 | issue= 7 Suppl | pages= 2147-50 | pmid=7522123 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7522123  }}</ref>


The worst case would be an '''open-and-close''' surgery, when surgeons find the tumor unresectable and the small bowel involved; any more procedures would do more harm than good to the patient. This is uncommon with the advent of laparoscopy and better radiological imaging.  Most of these cases formerly subjected to "open and close" procedures are now diagnosed in advance and surgery avoided.  
===Open-and-close Surgical Treatment===
*If the surgeons find the tumor unresectable and the small bowel is involved, any more procedures would do more harm than good to the patient   
*This is uncommon with [[laparoscopy]] and better radiological imaging.<ref name="pmid17298624">{{cite journal| author=Jones OM, John SK, Horseman N, Lawrance RJ, Fozard JB| title=Cause and place of death in patients dying with colorectal cancer. | journal=Colorectal Dis | year= 2007 | volume= 9 | issue= 3 | pages= 253-7 | pmid=17298624 | doi=10.1111/j.1463-1318.2006.01131.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17298624 }}</ref>
*Most of these cases formerly subjected to "open and close" procedures are now diagnosed in advance and surgery is avoided.


[[Laparoscopic surgery|Laparoscopic]]-assisted [[colectomy]] is a [[Minimally invasive procedure|minimally-invasive]] technique that can reduce the size of the incision, minimize the risk of infection, and reduce post-operative pain.  
===Laparoscopic-assisted Colectomy===
*This is a [[minimally invasive procedure|minimally-invasive]] technique that can reduce the size of the incision, minimize the risk of infection, and reduce post-operative pain.<ref name="pmid26108772">{{cite journal| author=Zhang S, Ding Z, Qiu X, Yuan S, Yan F, Hong X et al.| title=[Laparoscopic-assisted natural orifice specimen extraction radical left colectomy]. | journal=Zhonghua Wei Chang Wai Ke Za Zhi | year= 2015 | volume= 18 | issue= 6 | pages= 577-80 | pmid=26108772 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26108772  }}</ref>


As with any surgical procedure, colorectal surgery may result in complications including
==Complications with Colorectal Surgery==
* wound [[infection]], [[dehiscence]] (bursting of wound) or hernia
*Wound [[infection]]
* anastomosis breakdown, leading to abscess or fistula formation, and/or peritonitis
*[[Dehiscence]]
* bleeding with or without [[hematoma]] formation
*[[Hernia]]
* [[Adhesion (medicine)|adhesions]] resulting in [[bowel obstruction]] (especially small bowel)
*[[Anastomosis]] breakdown, leading to [[abscess]] or [[fistula]] formation and/or [[peritonitis]]
* [[blind loop syndrome]] as in bypass surgery.
*[[Bleeding]] with or without [[hematoma]] formation
* adjacent organ injury; most commonly to the small intestine, ureters, spleen, or bladder
*[[Adhesion (medicine)|Adhesions]] leading to [[bowel obstruction]]  
* Cardiorespiratory complications such as [[myocardial infarction]], [[pneumonia]], [[arrythmia]], [[pulmonary embolism]] etc
*[[Blind loop syndrome]] in bypass surgery
*Adjacent organ injury - most commonly to the [[small intestine]], [[ureters]], [[spleen]], or [[bladder]]
*[[Cardiorespiratory arrest|Cardiorespiratory]] complications such as [[myocardial infarction]], [[pneumonia]], [[arrythmia]], or [[pulmonary embolism]]  


==References==
==References==
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[[Category:Disease]]
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[[Category:Gastroenterology]]
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[[Category:Types of cancer]]
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[[Category:Conditions diagnosed by stool test]]
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Latest revision as of 01:10, 28 January 2019

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To view the surgery of familial adenomatous polyposis (FAP), click here
To view the surgery of hereditary nonpolyposis colorectal cancer (HNPCC), click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Elliot B. Tapper, M.D., Saarah T. Alkhairy, M.D.

Overview

Surgery remains the primary treatment while chemotherapy and/or radiotherapy may be recommended depending on the individual patient's staging and other medical factors.

Colorectal Cancer Surgery

Surgeries can be categorized into curative, palliative, bypass, open-and-close, or laparoscopic surgical treatment.

Curative Surgical Treatment

  • This surgical treatment can be offered if the tumor is localized.
  • Very early cancer that develops within a polyp can often be cured by removing the polyp (i.e., polypectomy) at the time of colonoscopy.
  • In colon cancer, a more advanced tumor typically requires surgical removal of the section of colon (i.e., colectomy) containing the tumor with sufficient margins, and radical en-bloc resection of mesentery and lymph nodes to reduce local recurrence.
  • If possible, the remaining parts of colon are anastomosed together to create a functioning colon, otherwise a stoma is created.

Palliative Surgical Treatment

  • In case of multiple metastases, a palliative resection of the primary tumor is still offered to reduce further morbidity.
  • Surgical removal of isolated liver metastases is common and may be curative[2]

Bypass Surgical Treatment

  • If the tumor invaded adjacent vital structures which makes excision technically difficult, surgeons may prefer to bypass the tumor (ileotransverse bypass) or to do a proximal fecal diversion through a stoma.[3]

Open-and-close Surgical Treatment

  • If the surgeons find the tumor unresectable and the small bowel is involved, any more procedures would do more harm than good to the patient
  • This is uncommon with laparoscopy and better radiological imaging.[4]
  • Most of these cases formerly subjected to "open and close" procedures are now diagnosed in advance and surgery is avoided.

Laparoscopic-assisted Colectomy

  • This is a minimally-invasive technique that can reduce the size of the incision, minimize the risk of infection, and reduce post-operative pain.[5]

Complications with Colorectal Surgery

References

  1. Peschaud F (2015). "[Surgical treatment of colorectal cancer]". Rev Prat. 65 (6): 779–83. PMID 26298899.
  2. McCullough JA, Engledow AH (2010). "Treatment options in obstructed left-sided colonic cancer". Clin Oncol (R Coll Radiol). 22 (9): 764–70. doi:10.1016/j.clon.2010.07.008. PMID 20729045.
  3. McGinnis LS (1994). "Surgical treatment options for colorectal cancer". Cancer. 74 (7 Suppl): 2147–50. PMID 7522123.
  4. Jones OM, John SK, Horseman N, Lawrance RJ, Fozard JB (2007). "Cause and place of death in patients dying with colorectal cancer". Colorectal Dis. 9 (3): 253–7. doi:10.1111/j.1463-1318.2006.01131.x. PMID 17298624.
  5. Zhang S, Ding Z, Qiu X, Yuan S, Yan F, Hong X; et al. (2015). "[Laparoscopic-assisted natural orifice specimen extraction radical left colectomy]". Zhonghua Wei Chang Wai Ke Za Zhi. 18 (6): 577–80. PMID 26108772.


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