CLCN6: Difference between revisions

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{{Infobox_gene}}
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'''Chloride transport protein 6''' is a [[protein]] that in humans is encoded by the ''CLCN6'' [[gene]].<ref name="pmid8543009">{{cite journal | vauthors = Brandt S, Jentsch TJ | title = ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family | journal = FEBS Lett | volume = 377 | issue = 1 | pages = 15–20 |date=Feb 1996 | pmid = 8543009 | pmc = | doi =10.1016/0014-5793(95)01298-2  }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chloride channel 6
| HGNCid = 2024
| Symbol = CLCN6
| AltSymbols =; CLC-6; KIAA0046
| OMIM = 602726
| ECnumber = 
| Homologene = 985
| MGIid = 1347049
| Function = {{GNF_GO|id=GO:0005247 |text = voltage-gated chloride channel activity}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0006884 |text = regulation of cell volume}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1185
    | Hs_Ensembl = ENSG00000011021
    | Hs_RefseqProtein = NP_001277
    | Hs_RefseqmRNA = NM_001286
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 11788855
    | Hs_GenLoc_end = 11825788
    | Hs_Uniprot = P51797
    | Mm_EntrezGene = 26372
    | Mm_Ensembl = ENSMUSG00000029016
    | Mm_RefseqmRNA = NM_011929
    | Mm_RefseqProtein = NP_036059
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 146850284
    | Mm_GenLoc_end = 146882567
    | Mm_Uniprot = Q3UM91
  }}
}}
'''Chloride channel 6''', also known as '''CLCN6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLCN6 chloride channel 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1185| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.<ref name="entrez">{{cite web | title = Entrez Gene: CLCN6 chloride channel 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1185| accessdate = }}</ref>
| summary_text = The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.<ref name="entrez">{{cite web | title = Entrez Gene: CLCN6 chloride channel 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1185| accessdate = }}</ref>
}}
}}
==See also==
* [[Chloride channel]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
*{{cite journal  | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi= }}
*{{cite journal  | vauthors=Nomura N, Nagase T, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223  |display-authors=etal}}
*{{cite journal  | author=Brandt S, Jentsch TJ |title=ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family. |journal=FEBS Lett. |volume=377 |issue= 1 |pages= 15-20 |year= 1996 |pmid= 8543009 |doi= }}
*{{cite journal  | vauthors=Eggermont J, Buyse G, Voets T |title=Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific |journal=Biochem. J. |volume=325 ( Pt 1) |issue=  Pt 1|pages= 269–76 |year= 1997 |pmid= 9224655 |doi=  | pmc=1218554  |display-authors=etal}}
*{{cite journal  | author=Eggermont J, Buyse G, Voets T, ''et al.'' |title=Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific. |journal=Biochem. J. |volume=325 ( Pt 1) |issue=  |pages= 269-76 |year= 1997 |pmid= 9224655 |doi=  }}
*{{cite journal  | author=Eggermont J |title=The exon-intron architecture of human chloride channel genes is not conserved |journal=Biochim. Biophys. Acta |volume=1397 |issue= 2 |pages= 156–60 |year= 1998 |pmid= 9565675 |doi=  10.1016/s0167-4781(98)00014-1}}
*{{cite journal  | author=Eggermont J |title=The exon-intron architecture of human chloride channel genes is not conserved. |journal=Biochim. Biophys. Acta |volume=1397 |issue= 2 |pages= 156-60 |year= 1998 |pmid= 9565675 |doi=  }}
*{{cite journal  | vauthors=Lamb FS, Clayton GH, Liu BX |title=Expression of CLCN voltage-gated chloride channel genes in human blood vessels |journal=J. Mol. Cell. Cardiol. |volume=31 |issue= 3 |pages= 657–66 |year= 1999 |pmid= 10198195 |doi= 10.1006/jmcc.1998.0901 |display-authors=etal}}
*{{cite journal  | author=Lamb FS, Clayton GH, Liu BX, ''et al.'' |title=Expression of CLCN voltage-gated chloride channel genes in human blood vessels. |journal=J. Mol. Cell. Cardiol. |volume=31 |issue= 3 |pages= 657-66 |year= 1999 |pmid= 10198195 |doi= 10.1006/jmcc.1998.0901 }}
*{{cite journal  | vauthors=Kornak U, Bösl MR, Kubisch C |title=Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1) |journal=Biochim. Biophys. Acta |volume=1447 |issue= 1 |pages= 100–6 |year= 1999 |pmid= 10500249 |doi=  10.1016/s0167-4781(99)00128-1}}
*{{cite journal  | author=Kornak U, Bösl MR, Kubisch C |title=Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1). |journal=Biochim. Biophys. Acta |volume=1447 |issue= 1 |pages= 100-6 |year= 1999 |pmid= 10500249 |doi=  }}
*{{cite journal  | vauthors=Lamb FS, Graeff RW, Clayton GH |title=Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium |journal=Am. J. Respir. Cell Mol. Biol. |volume=24 |issue= 4 |pages= 376–81 |year= 2001 |pmid= 11306429 |doi=  10.1165/ajrcmb.24.4.4114|display-authors=etal}}
*{{cite journal  | author=Lamb FS, Graeff RW, Clayton GH, ''et al.'' |title=Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=24 |issue= 4 |pages= 376-81 |year= 2001 |pmid= 11306429 |doi=  }}
*{{cite journal  | vauthors=Tran P, Leclerc D, Chan M |title=Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms |journal=Mamm. Genome |volume=13 |issue= 9 |pages= 483–92 |year= 2003 |pmid= 12370778 |doi= 10.1007/s00335-002-2167-6 |display-authors=etal}}
*{{cite journal  | author=Tran P, Leclerc D, Chan M, ''et al.'' |title=Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. |journal=Mamm. Genome |volume=13 |issue= 9 |pages= 483-92 |year= 2003 |pmid= 12370778 |doi= 10.1007/s00335-002-2167-6 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{MeshName|CLCN6+protein,+human}}
* {{UCSC gene info|CLCN6}}
 
{{NLM content}}
{{Ion channels|g4}}
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[[Category:Ion channels]]
 
 
{{gene-1-stub}}

Latest revision as of 09:45, 30 August 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.[1][2]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.[2]

See also

References

  1. ↑ Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett. 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009.
  2. ↑ 2.0 2.1 "Entrez Gene: CLCN6 chloride channel 6".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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