Breast cancer laboratory tests: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 5: Line 5:
==Overview==
==Overview==
An elevated concentration of serum [[alkaline phosphatase]] is diagnostic of bone metastasis of breast cancer.
An elevated concentration of serum [[alkaline phosphatase]] is diagnostic of bone metastasis of breast cancer.
==Blood Chemistry==
==Blood chemistry==
Blood chemistry tests measure certain chemicals in the blood. They show how well certain organs are functioning and can also be used to detect abnormalities. They are used to stage breast cancer. <ref name="ss">Breast cancer. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/breast/signs-and-symptoms/?region=on#ixzz3xScycfqv Accessed on January 16, 2016</ref>
Blood chemistry tests measure certain chemicals in the blood. They show how well certain organs are functioning and can also be used to detect abnormalities. They are used to stage breast cancer. <ref name="ss">Breast cancer. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/breast/signs-and-symptoms/?region=on#ixzz3xScycfqv Accessed on January 16, 2016</ref>
*[[Urea]] ([[blood urea nitrogen]] or [[Blood urea nitrogen|BUN]]) and [[creatinine]] may be measured to check kidney function. Kidney function is checked before chemotherapy is given and may be rechecked during or after treatment.
*[[Urea]] ([[blood urea nitrogen]] or [[Blood urea nitrogen|BUN]]) and [[creatinine]] may be measured to check kidney function. Kidney function is checked before chemotherapy is given and may be rechecked during or after treatment.
*[[Alanine transaminase|Alanine aminotransferase]] ([[Alanine transaminase|ALT]]), [[aspartate transaminase]] ([[Aspartate transaminase|AST]]) and [[alkaline phosphatase]] may be measured to check liver function.
*[[Alanine transaminase|Alanine aminotransferase]] ([[Alanine transaminase|ALT]]), [[aspartate transaminase]] ([[Aspartate transaminase|AST]]) and [[alkaline phosphatase]] may be measured to check liver function.
:*Increased levels could indicate that cancer has spread to the liver.
:*Increased levels could indicate that cancer has spread to the liver.
*Alkaline phosphatase can also be used to check for cancer in the bone.
*[[Alkaline phosphatase]] can also be used to check for cancer in the bone.
:*Increased levels could indicate that cancer has spread to the bone. Tumor markers such as [[Ki-67 (Biology)|'''Ki67''']]
:*Increased levels could indicate that cancer has spread to the [[bone]].  
:*Tumor markers such as [[Ki-67 (Biology)|'''Ki67''']]


==BRCA1/BRCA 2 Gene Testing==
==[[BRCA1]]/[[BRCA2]] Gene testing==
Genetic markers, if present, suggest an 80% likelihood of breast cancer occurrence.
Genetic markers, if present, suggest an 80% likelihood of breast cancer occurrence.


==HER2 Status Testing==
==HER2 Status testing==
*ERBB2 is a gene that has changed (mutated) so it helps a tumor grow oncogene. It is more commonly known as [[HER2]] (or HER2/neu). [[HER2]] stands for human epidermal growth factor receptor 2.<ref name="ss">Breast cancer. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/breast/signs-and-symptoms/?region=on#ixzz3xScycfqv Accessed on January 16, 2016</ref>
*ERBB2 is a gene that has changed (mutated) so it helps a tumor grow oncogene. It is more commonly known as [[HER2]] (or [[HER2/neu]]). [[HER2]] stands for human epidermal growth factor receptor 2.<ref name="ss">Breast cancer. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/breast/signs-and-symptoms/?region=on#ixzz3xScycfqv Accessed on January 16, 2016</ref>
*[[HER2]] status testing is done to find out the amount of [[HER2]] produced by a breast tumor.
*[[HER2]] status testing is done to find out the amount of [[HER2]] produced by a breast tumor.
Other Genetic panels such as:  
Other Genetic panels such as:  

Revision as of 04:23, 8 April 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2] Mirdula Sharma, MBBS [3]l; Ammu Susheela, M.D. [4]

Breast Cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Breast cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT scan

MRI

Echocardiography or Ultrasound

Other Imaging Studies

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Breast cancer laboratory tests On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Breast cancer laboratory tests

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Breast cancer laboratory tests

CDC on Breast cancer laboratory tests

Breast cancer laboratory tests in the news

Blogs on Breast cancer laboratory tests

Directions to Hospitals Treating Breast cancer

Risk calculators and risk factors for Breast cancer laboratory tests

Overview

An elevated concentration of serum alkaline phosphatase is diagnostic of bone metastasis of breast cancer.

Blood chemistry

Blood chemistry tests measure certain chemicals in the blood. They show how well certain organs are functioning and can also be used to detect abnormalities. They are used to stage breast cancer. [1]

  • Increased levels could indicate that cancer has spread to the liver.
  • Increased levels could indicate that cancer has spread to the bone.
  • Tumor markers such as Ki67

BRCA1/BRCA2 Gene testing

Genetic markers, if present, suggest an 80% likelihood of breast cancer occurrence.

HER2 Status testing

  • ERBB2 is a gene that has changed (mutated) so it helps a tumor grow oncogene. It is more commonly known as HER2 (or HER2/neu). HER2 stands for human epidermal growth factor receptor 2.[1]
  • HER2 status testing is done to find out the amount of HER2 produced by a breast tumor.

Other Genetic panels such as:

  • Oncotype DX®
  • MammaPrint®

References

  1. 1.0 1.1 Breast cancer. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/breast/signs-and-symptoms/?region=on#ixzz3xScycfqv Accessed on January 16, 2016

Template:WH Template:WS