User:Soroush Seifirad

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Soroush Seifirad, M.D.

Contact: Email: sseifira@bidmc.harvard.edu

Current Position

Professional Background

  • Soroush Seifirad, MD, currently holds a Research fellowship at PERFUSE study group, Division of Cardiology, Department of Medicine, BIDMC, Harvard Medical School. He serves as Associate Editor-In-Chief for WikiDoc Project.
  • Previously, he fulfilled a research fellowship at Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences (TUMS), Iran. He also had an affiliation with the Department of Cardiology in Children Medical Center, an affiliated hospital of TUMS.
  • His main research interest concerns inflammation and oxidative stress in Cardiopulmonary medicine but also translational medicine and disease modeling.
  • Dr. Seifirad published more than 40 peer-reviewed articles which were cited more than 490 times (h-index: 14, i10-index: 17). His research has been published in several leading journals such as Frontiers in Physiology, Echocardiography, Pediatric Cardiology, Respiration, Clinical and Experimental Rheumatology, Clinical Toxicology, Journal of Diabetes and Metabolic Disorders, and Medical Hypotheses.
  • Dr. Seifirad reviews for several journals such as BMJ case reports, Journal of Diabetes and Metabolic Disorders, Clinical and Experimental Toxicology, Iranian Journal of Public Health, Iranian Journal of Allergy, Asthma and Immunology, etc.”

Personal Interests

Curriculum Vitae

Soroush Seifirad, MD

PERFUSE Study Group

Division of Cardiology, Department of Medicine

Beth Israel Deaconess Medical Center

Harvard Medical School

https://orcid.org/0000-0003-2598-1899

Personal profile:

March 1984, Male, Bachelor, Iranian

Education:

1995-2002 Experimental Sciences Diploma from Iran's National Organization for Development of Exceptional Talents (NODET)

2002-2010 Medical Doctorate, Tabriz University of Medical Sciences

Memberships:

Medical Council, Iran I.R

European Respiratory Society, Silver Member

Professional Appointments:

2007-2008: Research Assistant, Drug Applied Research Center, Tabriz University of Medical Sciences

2009-2010: Executive Manager, Pulmonary and Critical Care Research Center, Tehran University of Medical Sciences

2010-2018: Research Fellow, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences

2010-present (Remote Contributor): Research Fellow, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences

2009-2018: Volunteer Research Fellow, Department of Cardiovascular Medicine, Children Medical Center, Tehran University of Medical Sciences

2019- present: Research fellow, PERFUSE Study Group, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School

Reviewing for the following journals:

BMJ case reports

Experimental Lung Research

Human and Experimental Toxicology (SAGE Publication)

Journal of Diabetes and Metabolic Disorders (Springer Publication)

Iranian Journal of Allergy, Asthma and Immunology

Iranian Journal of Public health, etc...

Innovations:

A: New Indications for old drugs:

1-     I was the first investigator that suggested and studied Pirfenidone for the treatment of Paraquat poisoning.(2012)

2-     Our team was one of the very first groups that proposed Colchicine for the treatment of Osteoarthritis. (2011)

3-     I have had the honor to be a member of one of the first groups that studied Sildenafil in the treatment of Fontan palliated patients.

B: Devices:

4-     Our team was one of the very first groups that recommended and studied the feasibility of hot biopsy forceps for endobronchial biopsy.

5-     As a medical student, I designed an extremely simple and affordable device that helped the patients (especially elderly) to inject a pre-titrated dose of insulin using traditional insulin injection and insulin vials. Healthcare practitioners will fix the dosage both for NPH and Regular for the day and night. The device is designed user-friendly with particular care for the people with decreased levels of a sigh as well as completely blinded patients. The application of this device eliminated the risk of overdoses and under-treatment with insulin.

C: Hypothetical concepts:

6-     For the first time, I have hypothesized that treatment with Apelin might reduce the risk of contrast-induced nephropathy in patients with congestive heart failure.

7-     I have suggested the concept of “reductive stress” and was one of the very first researchers that wrote against overtreatment with antioxidants.

Clinical experience:

1-     General practitioner: After graduation from medical school, I have served in several governmental as well as private clinics as a general practitioner. (2010 – 2018)

2-     Emergency room physician: I have worked as an ER man for several years in different emergency rooms and trauma centers. (2010 – 2018)

Management Experience:

1-     Executive manager, Pulmonary and Critical Care Research center, Tehran University of Medical Sciences. (2009-2011)

2-     Metabolic Disease Research Center (MDRC), Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences.  I have written the founding proposal for MDRC, including lab devices, materials, protocols, and research center office and laboratory structure. (2010)

Extracurricular activity:

3-     I have founded my own jewelry brand with a friend of mine (Nastaran and Soroush); I was responsible for designing, marketing, and advertising our products.

Teaching experience:

1-     Research methodology instructor at Tehran University of Medical Sciences, Students’ Scientific Research Center

Extracurricular activity:

2-     Music theory instructor, Tabriz University of Medical Sciences

3-     Private piano teacher, Tabriz and Tehran

Selected Publications:

Total Published Articles: 40, Total Citations: 483, h-index: 14, i10 index: 17

Theoretical articles:

1-     Seifirad S (corresponding author), A Ghaffari, MM Amoli. The antioxidants dilemma: are they potentially immunosuppressants and carcinogens? Front. Physiol. 2014. 5:245. doi: 10.3389/fphys.2014.0024.

2-     Seifirad S, Masoudkabir F. Apelin could reduce risk of contrast-induced nephropathy in patients with congestive heart failure. Medical Hypotheses. 81 (5), 898-900.

3-      Seifirad S (corresponding author). An emerging need for developing new models for myocardial infarction as a chronic complex disease: Lessons learnt from animal vs human studies on cardioprotective effects of Erythropoietin in reperfused myocardium. Front. Physiol. 2014. 5:44. doi:10.3389/fphys.2014.00044 .

4-      Seifirad S and Haghpanah V. Clothes Don't Make the Man: Well-favored Figures are Game-changers in the Biomedical Publication. J Korean Med Sci. 2015 Sep;30:e267. English.

5-     Seifirad S (corresponding author). A Randomized Controlled Trial of Hot versus Cold Biopsy Forceps in the Diagnosis of Endobronchial Lesions: strengths, pitfalls, and ethics points in the study designing. Respiration. 2011; 82(1):65.

6- Seifirad S (corresponding author). A comprehensive model for the asthma paradox: Is asthma a protective or a risk factor for malignancy? Medical Hypotheses. 2019. 109268.

7- Seifirad S (corresponding author) and Haghpanah V. Inappropriate Modeling of Chronic and Complex Disorders: How to Reconsider the Approach in the Context of Predictive, Preventive and Personalised Medicine, and Translational Medicine. EPMA Journal. 2019. 10(3) 195-209. https://doi.org/10.1007/s13167-019-00176-z

Experimental studies:

1-     Seifirad S (corresponding author), Keshavarz A, Taslimi S, Aran S, Abbasi H, Ghaffari, A. Effect of Pirfenidone on Pulmonary Fibrosis due to Paraquat Poisoning in Rats. Clin Toxicol (Phila). 2012;50(8):754-8.

2-     Argani H, Ghorbanihaghjo A, Rashtchizadeh N, Seifirad S, Rahbarfar Y. Effect of Cyclosporine-A on Paraoxonase Activity in Wistar Rats.  Int J Organ Transplant Med.   2011; 2(1): 25–31

3-     Seifirad S (corresponding author), Farzampour S, Nourbakhsh M, Amoli MM, Razzaghy-Azar M and Larijani B. Effects of extremely low frequency electromagnetic fields on paraoxonase serum activity and lipid peroxidation metabolites in rat. Journal of Diabetes & Metabolic Disorders. 2014, 13:85.

Clinical Trials:

1-     Ghorbanihaghjo A, Kolahi S, Seifirad S (corresponding author), Rashtchizadeh N, Argani H, Hajialilo M, Khabazi A, Alizadeh S, Bahreini E. Effect of fish oil supplements on serum paraoxonase activity in female patients with rheumatoid arthritis: a double-blind randomized controlled trial. Arch Iran Med. 2012;15(9):549-52.

2-      Aran S, Malekzadeh S, Seifirad S. A double-blind randomized controlled trial appraising the symptom-modifying effects of colchicine on osteoarthritis of the knee. Clin Exp Rheumatol. 2011 May-Jun;29(3):513-8.

3-     Firoozbakhsh S, Seifirad S (corresponding author), Safavi E, Dinparast R, Taslimi Sh, Derakhshandeilami Gh. Comparison of hot versus cold biopsy forceps in the diagnosis of endobronchial lesions. Arch Bronconeumol. 2011; 47(11):547-51.

4-     Mazdeh M, Taher A, Torabian S, and Seifirad S (corresponding author). Effects of normobaric hyperoxia in severe acute stroke: a randomized controlled clinical trial. Acta Med Iran. 2015. Nov;53(11):676-80.

5-      Zahedi H, Eghtesadi S, Seifirad S, Rezaee N, Shidfar F, Heydari I, et al. Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial. Journal of Diabetes & Metabolic Disorders. 2014; 13 (1), 81

6-     Shabanian R, Shahbaznejad L, Kiani A, Rahimzadeh M, Seifirad S, Kocharian A, Jami J Shakibi Gilani, Navabi MA. Sildenafil and ventriculo-arterial coupling in Fontan palliated patients. A noninvasive echocardiographic assessment. Pediatr Cardiol. 2013; 34:129–134.

Observational Studies:

1-     Shabanian R, Aboozari M, Kiani A, Seifirad S (corresponding author), Zamani Gh, Nahalimoghaddam A, Kocharian A. Myocardial Performance Index and Atrial Ejection Force in Patients with Duchenne’s Muscular Dystrophy. Echocardiography. 2011; 28(10):1088-1094.

2-     Shabanian R, Seifirad S (corresponding author), Kiani A, Kocharian A. Proper Use of Left Atrial Ejection Force as a Measure of Left Atrial Mechanical Function: Authors reply 2. Echocardiography. 2012; 29(7): 878–84.

3-     Kiani A, Shabanian R, Seifirad S (corresponding author), Heidari-Bateni G, Rekabi M, Shahbaznejad L, Dastmalchi R, Kocharian A. The impact of preload alteration on the myocardial performance index through implementing positive end expiratory pressure. Echocardiography. 2012; 29(8):900-5.

4-     Enayati S, Seifirad S (corresponding author), Amiri P, Abolhalaj, Amoli MM. Interleukin-1 beta, interferon-gamma, and tumor necrosis factor-alpha gene expression in peripheral blood mononuclear cells of patients with coronary artery disease. ARYA Atheroscler. 2015; 11(5): 267-74. 

5-     A Vasheghani-Farahani, N Nouri, S Seifirad, M Sheikh Fathollahi, E Hakki, et al. Comparison of cardiovascular risk factors and biochemical profile in patients with cardiac syndrome X and obstructive coronary artery disease: A propensity score-matched study. ARYA Atheroscler. 2013 9 (5), 269-73.

Other Published studies:

1-     Pourakbari B, Mamishi S, Zafari J, Khairkhah H, Ashtiani MH, Abedini M, Afsharpaiman Sh, Seifi Rad S. Evaluation of procalcitonin and neopterin level in serum of patients with acute bacterial infection.  Braz J Infect Dis 2010; 14(3):252-255.

2-     Mazdeh M,  Seifirad S (corresponding author), Kazemi N, Seifrabie MA, Dehghan A, Abbasi H. Comparison of vitamin D3 serum levels in new diagnosed patients with multiple sclerosis versus their healthy relatives. Acta medica Iranica 2013; 51(5): 289-292.

3-     Motamed F, Mohsenipour R, Seifirad S, Yusefi A, Farahmand F, et al. Red flags of organic recurrent abdominal pain in children: study on 100 subjects. Iranian journal of pediatrics. 2012. 22 (4), 457–462.

4-     Payab M, Motlagh AD, Eshraghian M, Rostami R, Siassi F, Ahmadi M, Karimi T, Mahjouri MY, Seifirad S. The association between depression, socio-economic factors and dietary intake in mothers having primary school children living in Rey, South of Tehran, Iran. Journal of Diabetes & Metabolic Disorders. 11 (1), 26

5-     Pazoki M, Goodarzi HM, Taheri AH, Seifirad S, Nematollahi N, et al. Prevalence of tuberculosis in patients with anthracosis: study on 150 subjects. Archives of Iranian medicine. 2012. 15 (3), 128-130.

6-     Heidarian A, Abbasi H, Hoseinabadi MH, Hajialibeyg A, Motamedi SMK, Seifirad S. Comparison of knifelight surgery versus conventional open surgery in the treatment of carpal tunnel syndrome. Iran Red Crescent Med J. 2013 May; 15(5): 385–388.

7-     Mohammadhoseini E, Safavi E Seifi, S, Seifirad S, Firoozbakhsh S, Peiman S. Effect of sample storage temperature and time delay on blood gases, bicarbonate and pH in human arterial blood samples. Iranian Red Crescent Medical Journal. 2015 Mar; 17(3): e13577.

8-     Aminimoghaddam S, Seifirad S, Abbasi DG, Abbasi N, Zare mehrjerdi A, Razavi SM, Mahmoudzadeh F. Uterine primitive neuroectodermal tumor. Archives of Iranian medicine. 2015. 18 (4), 260-262.

9-     KoochakHE, DavoudiS, OmranAS, MohsenipourR, Hajifathalian K, Saeidi B, Amirzargar AA, Sotoudeh M, Seifirad S. Diagnostic value of interferon-gamma assay in tuberculosis pericardial effusions: study on a cohort of Iranian patients. Acta Medica Iranica.2013. 51 (7), 449-453.

10-  Motamed F, Monajemzadeh M, Seifirad S, Ashrafi M, Rasti A, Mahjoub F. Liver storage disease in Iran: A ten year study of liver biopsies in Children Medical Center Hospital in Tehran-Iran. Hepat Mon. 2011 Aug 1; 11(8): 652–655.

11-  Safavi E, Rahimi B, Jafari S, Seifirad S (corresponding author), Derakhshandeilami Gh, Zahedpouranaraki M, Abtahi H. Sputum induction in the diagnosis of pulmonary tuberculosis in patients without sputum. Tehran University Medical Journal TUMS Publications. 2011. 69 (1), 43-48.

12-  Naghibi S, Seifirad S (Sirous is my little brother and this is his first article), Dehkordi MA, Einolghozati S, Moghadam NGE, Akhavan Rezayat A, Seifirad S. Comparison of conventional versus spiral computed tomography with three dimensional reconstruction in chronic otitis media with ossicular chain destruction. Iranian Journal of Radiology. 2016 Jan; 13(1): e9018.

13-  Firoozbakhsh S, Seifirad S, Safavi E, Derakhshandeilami G, Borsi H, Zahedpouranaraki M, Abtahi H.Feasibility of Chemical Pleurodesis with Small Bore Catheter in Patients with Symptomatic Malignant Pleural Effusions. Tur Toraks Der. 2012; 13: 18-22.

14-  Firoozbakhsh S, Seifirad S, Yamin V. Epidemiology of gasoline burn injuries in Tehran, Iran. Iran Red Crescent Med J. 2011 Mar; 13(3): 213–214.

15-  Seifirad S. Pirfenidone could decrease paraquat-induced pulmonary fibrosis in rats. Tzu Chi Medical Journal. 2013. 2 (25), 130.

16-  Firoozbakhsh S, Seifirad S, Safavi E, Vahedi H, Zahedpouranaraki M. The Etiologic Diagnosis of Chronic Cough in Patients Attending a University Affiliated Cough Clinic. Iran Red Crescent Med J. 2011 Jun; 13(6): 434–435.

17-Kahe F, Sharfaei S, Pitliya A, Jafarizade M, Seifirad S, Habibi Sh, and Chi G. Coronary artery tortuosity: a narrative review. Coronary Artery Disease. 2019. doi: 10.1097/MCA.0000000000000769. [Epub ahead of print]

Conference Presentations:

1) Seifirad S (presenting author), Hasanzadeh N, Ghaffari A, Talghini Sh. Effect of pulse therapy with glucocorticoids and Cyclophosphamide on lung fibrosis due to Paraquat poisoning in rat. European Respiratory Society Annual Congress, Barcelona 2010.

2) Abtahi HR, Seifirad S (presenting author), Abdi S. Does acute bronchodilator test is predictive of inhaled corticosteroid response in COPD/Asthma patients? European Respiratory Society Annual Congress, Barcelona 2010.

3-4) Seifirad S (presenting author), Mohammadhoseini E, Seifirad S, Safavi E. Does eradication of Helicobacter pylori decrease COPD exacerbation?

9th Lung Science Conference. Estoril. Portugal 2011.

European Respiratory Society (ERS) Annual Congress, Amsterdam 2011.

5-6 Firoozbakhsh S, Seifirad, S (presenting author), Dinparast R, Taslimi S,  Azari S, Safavi E. Comparison of hot versus cold biopsy forceps in the diagnosis of endobronchial lesions. European Respiratory Society (ERS) Annual Congress, Amsterdam 2011 Asociación Latinoamericana de Tórax (ALAT) annual congress, Montevideo, 2012

7) Masoudkabir F. Seifirad S, Davoudi S, Mohsenipour R, Salehi Omran A. Diagnostic value of gamma interferon assay in tuberculosis pericardial effusions: Study on a cohort of Iranian patients. European Respiratory Society (ERS) Annual Congress, Vienna 2012 (Accepted but not presented)

8-9-10) Seifirad S (presenting author), Keshavarz A; Taslimi S; Aran S; Abbasi H; Ghaffari A. Effect of Pirfenidone on pulmonary fibrosis due to Paraquat poisoning in rats.

10th Lung Science Conference, Estoril, Portugal 2012

Toxicology 2012, San Antonio, Texas, (invited but not presented)

European Respiratory Society (ERS) Annual Congress, Vienna 2012 (Accepted but not presented)

11-12-13) Mirfatahi M, Saedisomeolia A, Sotoudeh G, Mohajeri Tehrani MR, Keshavarz SA, Hosseini M, Seifirad S (Presented 2 of 3 accepted abstracts).

Effect of arginine supplementation on Blood pressure of prediabetic subjects. Effect of arginine supplementation on Glycemic control of prediabetic subjects.

Effect of arginine supplementation on anthropometric measures of prediabetic subjects.

International Diabetes Updates Congress, 2012, Tehran, Iran

14) Firoozbakhsh S, Seifirad S (presenting author), Dinparast R, Taslimi S, Azari S, Safavi E. Hot biopsy forceps: A forgotten promising technique. 12th Annual Silverman Institute for Health Care Quality and Safety Symposium, BIDMC, Harvard Medical School, Boston, Ma. USA.

WikiDoc Book Chapters

  1. Breast cancer
  2. Appendix cancer
  3. Primary cutaneous follicle centre lymphoma
  4. Mammography
  5. Breast Biopsy
  6. Multiple endocrine neoplasia / MEN syndrome
  7. Hepatopulmonary syndrome
  8. Loeffler syndrome
  9. Loeffler endocarditis
  10. Obesity cardiomyopathy
  11. Hypertrophic obstructive cardiomyopathy / Hypertrophic cardiomyopathy
  12. Third degree AV block / Complete heart block
Awards:

Scientific awards:

1-      Silver sponsorship ERS annual congress, 2010, Barcelona, Spain

2-      Top 40 Abstracts, Sponsored- Invited speaker, ALAT congress, 2012, Montevideo, Uruguay

3-      NODET Biology Olympics- Gold Medal- High school

4-      BASIJ Biology Olympics- Gold Medal- High school

Arts awards:

1-      Selected Music Composer: Announce of Iran International Festival of University Theater- 2008 Tabriz Iran

2-      Painting Gold Medal, Khorasan Province

3-      Awarded young Calligraphist, Khorasan Province

Championship Awards:

1-      National Champion, Mountain Climbing, (Grade 3 national Champion)

2-      Damavand- Climbing Certificate (5610m)

3-      Sabalan- Climbing Certificate (4811m)

4-      Certificates for mountain climbing, rock climbing, and Ice climbing and caving from Federation of Mountain and Rock Climbing and Winter Sports, IRAN I. R.

5-      ×3 Silver Medals in swimming competitions, Khorasan Province

6-      Member, the Basketball team of Tabriz University of Medical Science, for 6 years

7-      Bronze Medal, Basketball, High school, Khorasan Province Competitions

8-      Gold Medal, Basketball, High School, Khorasan Province Competitions

Language Skills:

1-      Persian (Native speaker)

2-      English (Professional), TOEFL score:102

3-      Turkish-Azari (Professional)

4-      French (Elementary),

Computer Skills:

1-      Word

2-      PowerPoint

3-      SPSS

4-      End-note

Leisure interests:

1-      Playing piano (I have performed in several piano recitals)

2-      Composing music: I have composed several music pieces. (Both orchestral compositions and piano solos)

3-      Painting, oil painting, watercolor painting, sculpture

4-      Photography

5-      Mountain climbing and traveling

6-      Books

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