Attention-deficit hyperactivity disorder overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2], Haleigh Williams, B.S.

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Attention-Deficit Hyperactivity Disorder from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Psychiatric Examination

Laboratory Findings

Imaging Findings

Treatment

Medical Therapy

Psychotherapy

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Cost-Effectiveness of Therapy

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Overview

  • Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioral brain disorder marked by an ongoing pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. It may negatively impact the patient’s academic or professional performance and/or social interactions.
  • ADHD has a strong component of heritability.
  • ADHD is more commonly diagnosed in boys than in girls, though this may be because the symptoms of the disorder are less easily recognized in girls.[1]

Historical Perspective

  • ADHD symptoms have been recognized in children and described in medical texts since the nineteenth century, though the formal diagnosis had not yet been devised.
  • ADHD was first included in some form in the DSM in its second edition, when it was referred to as “hyperkinetic reaction of childhood.” It was not until the third edition of the DSM was released in 1980 that the disorder was formally identified as “ADD (Attention-Deficit Disorder) with or without hyperactivity.”[2]
  • Rhode Island physician Dr. Charles Bradley pioneered the use of medications to treat ADHD in 1937. Since that time, the prescription of stimulants has become a first-line treatment for ADHD.[3]

Classification

ADHD may be classified according to the DSM V criteria into three subgroups:

Pathophysiology

  • ADHD appears to be highly heritable, although one-fifth of all cases are estimated to be caused by trauma or exposure to toxins.
  • Evidence suggests that ADHD is a heterogeneous disorder, meaning that several causes could create very similar symptomology.[5]
  • Although there is evidence for dopamine abnormalities in ADHD, it is not clear whether abnormalities of the dopamine system are a molecular abnormality of ADHD or a secondary consequence of ADHD.

Causes

There are no established causes of ADHD. Studies suggest that ADHD results from a complex interaction between genetic and environmental factors.[6]

Differentiating Attention Deficit Hyperactivity Disorder from other Diseases

Epidemiology and Demographics

  • The prevalence of attention-deficit hyperactivity disorder (ADHD) is estimated to be 5,000 per 100,000 (5%) children and 2,500 per 100,000 (2.5%) adults.[4]
  • Boys are more commonly affected by ADHD than girls. The male to female ratio is 2 to 1.[8]

Risk Factors

Common risk factors in the development of attention-deficit hyperactivity disorder (ADHD) are:[4]

Natural History, Complications and Prognosis

  • If left untreated, patients with ADHD may experience negative social consequences, such as isolation from and difficulty communicating with friends and loved ones.
  • Patients are unlikely to experience any physical problems as a direct result of ADHD.[9]

Diagnosis

The diagnosis of ADHD is made based on the DSM V criteria, which can be found on the Attention-deficit hyperactivity disorder diagnostic criteria page.

History and Symptoms

  • The most common symptoms of ADHD include chronic and long-lasting hyperactivity, impulsivity, and inattention.[1]
  • It is particularly important to collect a family history with regard to psychiatric disorders, as ADHD has such a strong genetic component.[10]
  • It is also vital to understand how long the patient has been experiencing symptoms of ADHD, as the DSM V stipulates that symptoms must have been present for at least 6 months in order for a diagnosis of ADHD to be made. Similarly, an adult cannot be diagnosed with ADHD unless his/her symptoms were present prior to the age of 12 years.[4]

Physical Examination

Laboratory Findings

  • There are no laboratory findings associated with ADHD.

Electrocardiogram

  • There are no ECG findings associated with ADHD.

Chest X Ray

  • There are no chest x-ray findings associated with ADHD.

CT Scan

  • There are no CT scan findings associated with ADHD.

Electrocardiography or Ultrasound

  • There are no echocardiography or ultrasound findings associated with ADHD.

Other Imaging Findings

  • Though the brains of ADHD patients follow a normal pattern of development, imaging findings indicative of ADHD may include delayed physical development of the brain. This may help explain why some adolescent ADHD patients do not experience symptoms into adulthood.[11]

Treatment

The mainstay of therapy for ADHD is the administration of such stimulants as Ritalin and Adderall. While there is no cure for ADHD, currently available treatments can help reduce symptoms and improve functioning. Other treatment options include psychotherapy, education and training, or a combination of therapies.[1]

Medical Therapy

Surgery

Surgical intervention is not recommended for the management of ADHD.

Prevention

  • There is no established method for the prevention of ADHD. Although there is no proven way to prevent ADHD, early identification and treatment can prevent many of the problems associated with ADHD.[1]
  • Secondary prevention strategies following a diagnosis of ADHD include the administration of stimulants, cognitive behavioral therapy, and regular psychiatric evaluations.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 National Institute of Mental Health (NIH). (2016). "Attention Deficit Hyperactivity Disorder."
  2. Lange, K. W., Reichl, S., Lange, K. M., Tucha, L., & Tucha, O. (2010). The history of attention deficit hyperactivity disorder. Attention Deficit and Hyperactivity Disorders, 2(4), 241–255. http://doi.org/10.1007/s12402-010-0045-8.
  3. Strohl, M. P. (2011). Bradley’s Benzedrine Studies on Children with Behavioral Disorders. The Yale Journal of Biology and Medicine, 84(1), 27–33.
  4. 4.0 4.1 4.2 4.3 Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
  5. Barkley, Russel A. "Attention-Deficit/Hyperactivity Disorder: Nature, Course, Outcomes, and Comorbidity". Retrieved 2006-06-26.
  6. OurMed. (2010). "Attention-deficit hyperactivity disorder."
  7. Cross-Disorder Group of the Psychiatric Genomics Consortium. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 381(9875), 1371–1379. http://doi.org/10.1016/S0140-6736(12)62129-1.
  8. Briars, L., & Todd, T. (2016). A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder. The Journal of Pediatric Pharmacology and Therapeutics : JPPT, 21(3), 192–206. http://doi.org/10.5863/1551-6776-21.3.192.
  9. Briars, L., & Todd, T. (2016). A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder. The Journal of Pediatric Pharmacology and Therapeutics : JPPT, 21(3), 192–206. http://doi.org/10.5863/1551-6776-21.3.192
  10. Cross-Disorder Group of the Psychiatric Genomics Consortium. "Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs." Nat Genet. (2013). 45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11.
  11. Brain Matures a Few Years Late in ADHD, But Follows Normal Pattern NIMH Press Release, November 12, 2007


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