Aspergillosis other diagnostic studies: Difference between revisions

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__NOTOC__
__NOTOC__
{{Aspergillosis}}
{{Aspergillosis}}
{{CMG}} {{AE}} {{HL}}
{{CMG}} {{AE}} {{HL}}; {{YD}}; {{SSK}}
==Overview==
==Overview==
Skin biopsy may be helpful in the diagnosis of cutaneous aspergillosis.<ref name="pmid19179225">{{cite journal| author=Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP| title=Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis. | journal=Lancet Infect Dis | year= 2009 | volume= 9 | issue= 2 | pages= 89-96 | pmid=19179225 | doi=10.1016/S1473-3099(09)70019-2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19179225  }} </ref><ref name="pmid9774549">{{cite journal| author=van Burik JA, Colven R, Spach DH| title=Cutaneous aspergillosis. | journal=J Clin Microbiol | year= 1998 | volume= 36 | issue= 11 | pages= 3115-21 | pmid=9774549 | doi= | pmc=PMC105285 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9774549  }} </ref>
==Other Diagnostic Studies==
==Other Diagnostic Studies==
===Skin Biopsy===
===Skin Biopsy===
* Skin biopsy is helpful in the diagnosis of cutaneous aspergillosis.  
* Skin biopsy is helpful in the diagnosis of cutaneous aspergillosis.  
* Histopathologic examination with [[hematoxylin]] and [[eosin]] will variably demonstrate Aspergillus hyphae.<ref name="pmid9774549">{{cite journal| author=van Burik JA, Colven R, Spach DH| title=Cutaneous aspergillosis. | journal=J Clin Microbiol | year= 1998 | volume= 36 | issue= 11 | pages= 3115-21 | pmid=9774549 | doi= | pmc=PMC105285 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9774549  }} </ref>
* Histopathologic examination with [[hematoxylin]] and [[eosin]] will variably demonstrate ''Aspergillus'' hyphae.<ref name="pmid9774549">{{cite journal| author=van Burik JA, Colven R, Spach DH| title=Cutaneous aspergillosis. | journal=J Clin Microbiol | year= 1998 | volume= 36 | issue= 11 | pages= 3115-21 | pmid=9774549 | doi= | pmc=PMC105285 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9774549  }} </ref>
* The Gomori methenamine [[silver stain]], however, clearly detects [[hyphae]], since the hyphal [[cell wall]] stains black, while the background tissue stains green.  
* The Gomori methenamine [[silver stain]], however, clearly detects [[hyphae]], since the hyphal [[cell wall]] stains black, while the background tissue stains green.  
* Aspergillus [[hyphae]] should have acute-angle branching and frequent septations on histopathological examination.
* Aspergillus [[hyphae]] should have acute-angle branching and frequent septations on histopathological examination.


===PCR===
A single negative PCR result is enough to exclude a diagnosis of a probable invasive aspergillosis.<ref name="pmid19179225">{{cite journal| author=Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP| title=Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis. | journal=Lancet Infect Dis | year= 2009 | volume= 9 | issue= 2 | pages= 89-96 | pmid=19179225 | doi=10.1016/S1473-3099(09)70019-2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19179225  }} </ref>
While, two positive test results are required to confirm a diagnosis of aspergillosis. 
==Gallery==
==Gallery==


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{{Reflist|2}}
{{Reflist|2}}
[[Category:Disease]]
[[Category:Disease]]
[[Category:Infectious disease]]
{{Mycoses}}


[[Category:Fungal diseases]]
[[Category:Fungal diseases]]
[[Category:Infectious disease]]
}

Latest revision as of 17:01, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.

Overview

Skin biopsy may be helpful in the diagnosis of cutaneous aspergillosis.[1][2]

Other Diagnostic Studies

Skin Biopsy

  • Skin biopsy is helpful in the diagnosis of cutaneous aspergillosis.
  • Histopathologic examination with hematoxylin and eosin will variably demonstrate Aspergillus hyphae.[2]
  • The Gomori methenamine silver stain, however, clearly detects hyphae, since the hyphal cell wall stains black, while the background tissue stains green.
  • Aspergillus hyphae should have acute-angle branching and frequent septations on histopathological examination.

Gallery

References

  1. Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP (2009). "Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis". Lancet Infect Dis. 9 (2): 89–96. doi:10.1016/S1473-3099(09)70019-2. PMID 19179225.
  2. 2.0 2.1 van Burik JA, Colven R, Spach DH (1998). "Cutaneous aspergillosis". J Clin Microbiol. 36 (11): 3115–21. PMC 105285. PMID 9774549.
  3. 3.0 3.1 3.2 "Public Health Image Library (PHIL)".