Alzheimer's disease history and symptoms: Difference between revisions
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{{Alzheimer's disease}} | {{Alzheimer's disease}} | ||
==Overview== | ==Overview== | ||
Although each patient experiences Alzheimer's in a unique way, there are many common symptoms. | Although each patient experiences Alzheimer's disease (AD) in a unique way, there are many common [[symptoms]]. The earliest observable symptoms are often mistaken for normal effects of [[aging]] or manifestations of [[Stress (medicine)|stress]]. | ||
==History== | |||
Obtaining patient's history is an important aspect of making a [[diagnosis]] of Alzheimer's disease. It provides an insight into precipitating factors and associated comorbid conditions. Complete history will help determine the correct [[therapy]] and helps in determining the [[prognosis]]. Alzheimer's disease patients may be [[Disorientation|disoriented]] and therefore the patient interview may be difficult. In such cases history from the care givers or the family members may need to be obtained. Specific histories about the [[symptoms]] (duration, onset, progression), associated [[symptoms]], [[drug]] usage have to be obtained. Specific areas of focus when obtaining the history, are outlined below: | |||
* Onset, duration and progression of [[symptoms]] (especially memory and daily activities) | |||
* History of [[falls]] | |||
* Associated symptoms ([[lethargy]], or [[confusion]]) | |||
* [[Medications]] | |||
* History of [[Trauma]] | |||
* Symptoms of other [[organ failure]] such as ([[renal failure]] or [[liver failure]] | |||
| | * [[Poisons]] or [[chemicals]] ingested | ||
* Co-morbid conditions such as [[diabetes]] or [[hypertension]] | |||
* [[Sepsis|Severe infections]] | |||
* Any history for severe loss of [[fluids]] | |||
* Exposure to [[toxic substances]] | |||
| | |||
==Symptoms== | ==Symptoms== | ||
The most commonly recognized symptom of early Alzheimer's disease is [[memory loss]], which usually involves | The most commonly recognized [[symptom]] of early Alzheimer's disease (AD) is [[memory loss]], which usually involves forgetfulness of recently learned facts. As the [[disease]] advances, symptoms include [[Mental confusion|confusion]], [[irritability]], aggression, [[mood swings]], language breakdown, [[long-term memory]] loss, and the general withdrawal of the sufferer as their senses decline. <ref name="pmid17222085">{{cite journal| author=Waldemar G, Dubois B, Emre M, Georges J, McKeith IG, Rossor M et al.| title=Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline. | journal=Eur J Neurol | year= 2007 | volume= 14 | issue= 1 | pages= e1-26 | pmid=17222085 | doi=10.1111/j.1468-1331.2006.01605.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17222085 }} </ref><ref name="pmid17823840">{{cite journal| author=Hinton L, Franz CE, Reddy G, Flores Y, Kravitz RL, Barker JC| title=Practice constraints, behavioral problems, and dementia care: primary care physicians' perspectives. | journal=J Gen Intern Med | year= 2007 | volume= 22 | issue= 11 | pages= 1487-92 | pmid=17823840 | doi=10.1007/s11606-007-0317-y | pmc=2219799 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17823840 }} </ref>. Gradually, bodily functions are lost, ultimately leading to death.<ref name="nihstages">{{cite web | ||
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}}</ref> Gradually, bodily functions are lost, ultimately leading to death.<ref name="nihstages"> | |||
{{cite web | |||
| title=Understanding stages and symptoms of Alzheimer's disease | | title=Understanding stages and symptoms of Alzheimer's disease | ||
| url=http://www.nia.nih.gov/Alzheimers/Publications/stages.htm | | url=http://www.nia.nih.gov/Alzheimers/Publications/stages.htm | ||
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'''Dementia symptoms include difficulty with many areas of mental function, including:''' | '''Dementia symptoms include difficulty with many areas of mental function, including:''' | ||
* Language | * [[Language]] | ||
* [[Memory]] | * [[Memory]] | ||
* [[Perception]] | * [[Perception]] | ||
* Emotional behavior or personality | * [[Emotional]] [[behavior]] or [[personality]] | ||
* Cognitive skills (such as calculation, abstract thinking, or judgment) | * [[Cognitive]] skills (such as calculation, abstract thinking, or judgment) | ||
[[Dementia]] usually first manifests as [[forgetfulness]]. | [[Dementia]] usually first manifests as [[forgetfulness]]. | ||
[[Mild cognitive impairment]] is the stage between normal [[forgetfulness]] due to [[aging]] and the development of AD. People with MCI have mild problems with thinking and memory that do not interfere with everyday activities. They are often aware of the [[forgetfulness]]. Not everyone with MCI develops AD. | [[Mild cognitive impairment]] is the stage between normal [[forgetfulness]] due to [[aging]] and the development of [[Alzheimer's disease|Alzheimer's disease (AD)]]. People with [[Mild cognitive impairment|MCI]] have mild problems with thinking and [[memory]] that do not interfere with everyday activities. They are often aware of the [[forgetfulness]]. Not everyone with [[Mild cognitive impairment|MCI]] develops Alzheimer's disease (AD). | ||
'''Symptoms of mild cognitive impairment include:''' | '''Symptoms of mild cognitive impairment include:''' | ||
* | * [[Forgetfulness]] of recent events or conversations | ||
* Difficulty performing more than one task at a time | * Difficulty performing more than one task at a time | ||
* Difficulty solving problems | * Difficulty solving problems | ||
* Taking longer to perform more difficult activities | * Taking longer to perform more difficult activities | ||
'''The early symptoms of AD can include:''' | '''The early symptoms of Alzheimer's disease (AD) can include:''' | ||
* Language problems, such as trouble finding the name of familiar objects | * [[Language]] problems, such as trouble finding the name of familiar objects | ||
* Misplacing items | * Misplacing items | ||
* Getting lost on familiar routes | * Getting lost on familiar routes | ||
* Personality changes and loss of social skills | * [[Personality changes]] and loss of [[social skills]] | ||
* Losing interest in things previously enjoyed; flat | * Losing [[Interest (emotion)|interest]] in things previously enjoyed; [[flat affect]] | ||
* Difficulty performing tasks that take some thought, but used to come easily, such as balancing a checkbook, playing complex games (such as bridge), and learning new information or routines | * Difficulty performing tasks that take some thought, but used to come easily, such as balancing a checkbook, playing complex games (such as bridge), and learning new information or routines | ||
'''As the AD becomes worse, symptoms are more obvious and interfere with your ability to take care of yourself. Symptoms can include:''' | '''As the Alzheimer's disease (AD) becomes worse, symptoms are more obvious and interfere with your ability to take care of yourself. Symptoms can include:''' | ||
* Forgetting details about current events | * [[Forgetting]] details about current events | ||
* Forgetting events in your own life history, losing awareness of who you are | * [[Forgetting]] events in your own life [[History & Symptoms|history]], losing awareness of who you are | ||
* Change in sleep patterns, often waking up at night | * Change in sleep patterns, often waking up at night | ||
* Difficulty reading or writing | * Difficulty [[reading]] or [[writing]] | ||
* Poor judgment and loss of ability to recognize danger | * Poor judgment and loss of ability to recognize danger | ||
* Using the wrong word, mispronouncing words, speaking in confusing sentences | * Using the wrong word, mispronouncing words, speaking in confusing sentences | ||
* Withdrawing from social contact | * Withdrawing from social contact | ||
* Having hallucinations, arguments, striking out, and violent behavior | * Having [[Hallucination|hallucinations]], arguments, striking out, and violent behavior | ||
* Having delusions, depression, agitation | * Having [[delusions]], [[depression]], [[agitation]] | ||
* Difficulty doing basic tasks, such as preparing meals, choosing proper clothing, and driving | * Difficulty doing basic tasks, such as preparing meals, choosing proper clothing, and driving | ||
'''People with severe AD can no longer:''' | '''People with severe '''Alzheimer's disease (AD)''' can no longer:''' | ||
* Understand language | * Understand [[language]] | ||
* Recognize family members | * Recognize family members | ||
* Perform basic activities of daily living, such as eating, dressing, and bathing | * Perform basic activities of daily living, such as eating, dressing, and bathing | ||
'''Other symptoms that may occur with AD:''' | '''Other symptoms that may occur with '''Alzheimer's disease (AD)''':''' | ||
* [[Incontinence]] | * [[Incontinence]] | ||
* [[Swallowing problems]] | * [[Swallowing problems]] | ||
Latest revision as of 16:24, 21 September 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Abdurahman Khalil, M.D. [2]
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Risk calculators and risk factors for Alzheimer's disease history and symptoms |
Overview
Although each patient experiences Alzheimer's disease (AD) in a unique way, there are many common symptoms. The earliest observable symptoms are often mistaken for normal effects of aging or manifestations of stress.
History
Obtaining patient's history is an important aspect of making a diagnosis of Alzheimer's disease. It provides an insight into precipitating factors and associated comorbid conditions. Complete history will help determine the correct therapy and helps in determining the prognosis. Alzheimer's disease patients may be disoriented and therefore the patient interview may be difficult. In such cases history from the care givers or the family members may need to be obtained. Specific histories about the symptoms (duration, onset, progression), associated symptoms, drug usage have to be obtained. Specific areas of focus when obtaining the history, are outlined below:
- Onset, duration and progression of symptoms (especially memory and daily activities)
- History of falls
- Associated symptoms (lethargy, or confusion)
- Medications
- History of Trauma
- Symptoms of other organ failure such as (renal failure or liver failure
- Poisons or chemicals ingested
- Co-morbid conditions such as diabetes or hypertension
- Severe infections
- Any history for severe loss of fluids
- Exposure to toxic substances
Symptoms
The most commonly recognized symptom of early Alzheimer's disease (AD) is memory loss, which usually involves forgetfulness of recently learned facts. As the disease advances, symptoms include confusion, irritability, aggression, mood swings, language breakdown, long-term memory loss, and the general withdrawal of the sufferer as their senses decline. [1][2]. Gradually, bodily functions are lost, ultimately leading to death.[3]
Dementia symptoms include difficulty with many areas of mental function, including:
- Language
- Memory
- Perception
- Emotional behavior or personality
- Cognitive skills (such as calculation, abstract thinking, or judgment)
Dementia usually first manifests as forgetfulness.
Mild cognitive impairment is the stage between normal forgetfulness due to aging and the development of Alzheimer's disease (AD). People with MCI have mild problems with thinking and memory that do not interfere with everyday activities. They are often aware of the forgetfulness. Not everyone with MCI develops Alzheimer's disease (AD).
Symptoms of mild cognitive impairment include:
- Forgetfulness of recent events or conversations
- Difficulty performing more than one task at a time
- Difficulty solving problems
- Taking longer to perform more difficult activities
The early symptoms of Alzheimer's disease (AD) can include:
- Language problems, such as trouble finding the name of familiar objects
- Misplacing items
- Getting lost on familiar routes
- Personality changes and loss of social skills
- Losing interest in things previously enjoyed; flat affect
- Difficulty performing tasks that take some thought, but used to come easily, such as balancing a checkbook, playing complex games (such as bridge), and learning new information or routines
As the Alzheimer's disease (AD) becomes worse, symptoms are more obvious and interfere with your ability to take care of yourself. Symptoms can include:
- Forgetting details about current events
- Forgetting events in your own life history, losing awareness of who you are
- Change in sleep patterns, often waking up at night
- Difficulty reading or writing
- Poor judgment and loss of ability to recognize danger
- Using the wrong word, mispronouncing words, speaking in confusing sentences
- Withdrawing from social contact
- Having hallucinations, arguments, striking out, and violent behavior
- Having delusions, depression, agitation
- Difficulty doing basic tasks, such as preparing meals, choosing proper clothing, and driving
People with severe Alzheimer's disease (AD) can no longer:
- Understand language
- Recognize family members
- Perform basic activities of daily living, such as eating, dressing, and bathing
Other symptoms that may occur with Alzheimer's disease (AD):
References
- ↑ Waldemar G, Dubois B, Emre M, Georges J, McKeith IG, Rossor M; et al. (2007). "Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline". Eur J Neurol. 14 (1): e1–26. doi:10.1111/j.1468-1331.2006.01605.x. PMID 17222085.
- ↑ Hinton L, Franz CE, Reddy G, Flores Y, Kravitz RL, Barker JC (2007). "Practice constraints, behavioral problems, and dementia care: primary care physicians' perspectives". J Gen Intern Med. 22 (11): 1487–92. doi:10.1007/s11606-007-0317-y. PMC 2219799. PMID 17823840.
- ↑ "Understanding stages and symptoms of Alzheimer's disease". National Institute on Aging. 2007-10-26. Retrieved 2008-02-21.