Sandbox/AL

Pathogen-Based Therapy — Bacteria Adapted from

▸ Click on the following categories to expand treatment regimens.

Bacteria   ▸  Staphylococcus aureus   ▸  Staphylococcus epidermidis   ▸  Methicillin-resistant S. aureus   ▸  Streptococcus groups A, B, C, G   ▸  Enterococcus feacalis

Staphylococcus aureus Preferred Regimen ▸ Nafcillin 2 g IV q6h Alternative Regimen ▸ Vancomycin OR ▸ Cefazolin OR ▸ Clindamycin Staphylococcus epidermidis Preferred Regimen ▸ Vancomycin 15 mg/kg IV q12h Alternative Regimen ▸ TMP-SMX OR Methicillin-resistant S. aureus Preferred Regimen ▸ Vancomycin 15 mg/kg IV q12h Alternative Regimen ▸ TMP-SMX OR ▸ Doxycycline OR ▸ Linezolid Streptococcus groups A, B, C, G Preferred Regimen ▸ Penicillin G 2 MU IV q4h Alternative Regimen ▸ Vancomycin OR ▸ Cefazolin OR ▸ Erythromycin Enterococcus faecalis Preferred Regimen ▸ Penicillin G 2 MU IV q4h OR ▸ Ampicillin 2 g IV q6h PLUS ▸ Gentamicin 1 mg/kg IV or IM q8h Alternative Regimen Vancomycin PLUS ▸ Gentamicin 1 mg/kg IV or IM q8h N. meningitidis, Penicillin MIC ≥0.1 μg/mL Preferred Regimen ▸ Cefotaxime 2 g IV q4—6h OR ▸ Ceftriaxone 2 g IV q12h Alternative Regimen ▸ Cefepime 2 g IV q8h OR ▸ Chloramphenicol 1—1.5 g IV q6h OR ▸ Moxifloxacin 400 mg IV q24h OR ▸ Meropenem 2 g IV q8h Pseudomonas aeruginosa Preferred Regimen ▸ Ceftazidime 2 g IV q8h OR ▸ Cefepime 2 g IV q8h PLUS ▸ Gentamicin 1.7 mg/kg IV q8h Alternative Regimen ▸ Aztreonam 2 g IV q6—8h OR ▸ Meropenem 2 g IV q8h OR ▸ Ciprofloxacin 400 mg IV q8—12h PLUS Expand▸ Gentamicin 1.7 mg/kg IV q8h Staphylococcus aureus, Methicillin sensitive Preferred Regimen ▸ Nafcillin 1.5—2 g IV q4h OR ▸ Oxacillin 1.5—2 g IV q4h Alternative Regimen ▸ Vancomycin 15 mg/kg IV q6h (trough 15—20 μg/mL) OR ▸ Linezolid 600 mg IV q12h OR ▸ Daptomycin 6 mg/kg IV q24h Staphylococcus aureus, Methicillin resistant Preferred Regimen ▸ Vancomycin 15 mg/kg IV q6h (trough 15—20 μg/mL) PLUS ▸ Rifampin 600 mg IV q24h Alternative Regimen ▸ TMP/SMZ 5 mg/kg IV q6—12h (TMP component) OR ▸ Linezolid 600 mg IV q12h OR ▸ Daptomycin 6 mg/kg IV q24h PLUS Expand▸ Rifampin 600 mg IV q24h