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H. Influenzae
Preferred Regimen
Ceftriaxone 50 mg/kg IV q12h
If Penicillin Allergic
Chloramphenicol 12.5 mg/kg IV q6h (max. 4 gm/day.)
Listeria Monocytogenes
Preferred Regimen
Ampicillin 50 mg/kg IV q12h 2mg iv q4h
PLUS OR NOT
gentamicin 2 mg/kg loading dose then 1.7kg/mg q8h
If Penicillin Allergic
TMP-SMX 20 mg/kg/day q6–12h
Alternative Regimen
Meropenem 2 mg IV q8h
N. meningitidis
Preferred Regimen
Ceftriaxone 2 mg IV q12hx 7 days
If Ȕ-Lactam Allergic
Chloro 12.5 mg/kg (up to 1 gm) IV q6h
Alternative Regimen
Meropenem 2 gm IV q8h
OR
Moxifloxacin 400 mg q24h
E. coli, other coliforms, or P. aeruginosa
Preferred Regimen
Ceftazidime2 gm IV q8h
OR
cefepime 2 gm IV q8h
PLUS OR NOT
Gentamicin
Alternative Regimen
Ciprofloxacin 400 mg IV q8–12h
OR
MeropenemR 2 gm IV q8h


S. pneumoniae
Pen G MIC <0.1 mcg/mL
Penicillin G 4 million units IV q4h
OR
Ampicillin 2 gm IV

q4h

Alternative Regimen
Ceftriaxone 2 gm IV q12h
OR

Chloramphenicol 1 gm IV q6h

Pen G MIC :0.1–1 mcg/mL
Ceftriaxone 2 gm IV q12h
OR
Cefotaxime 2 gm IV q4–6h
Alternative Regimen
Cefepime 2 gm IV q8h
OR
Meropenem 2 gm IV q8h
Pen G MIC :≥2 mcg/mL
Vancomycin 500–750 mg IV q6h
PLUS
Ceftriaxone 2 gm IV q12h
OR
Cefotaxime 2 gm IV q4–6h
Alternative Regimen
Moxifloxacin 400 mg IV q24h
Ceftriaxone MIC ≥ 1mcg/mL
Vancomycin 500–750 mg IV q6h
PLUS
Ceftriaxone 2 gm IV q12h
OR
Cefotaxime 2 gm IV q4–6h
Alternative Regimen
Moxifloxacin 400 mg IV q24h
If MIC to ceftriaxone >2 mcg/mL, add RIF 600 mg 1x/day