Sandbox/v12

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Community-acquired meningitis
Age <1 Week
Preferred Regimen
Ampicillin 50 mg/kg IV q8h
AND
Cefotaxime 100—150 mg/kg/day IV q8—12h
Alternative Regimen
Ampicillin 50 mg/kg IV q8h
AND
Gentamicin 2.5 mg/kg IV q12h




Age 1—4 Weeks
Preferred Regimen
Ampicillin 200 mg/kg/day IV q6—8h
AND
Cefotaxime 150—200 mg/kg/day IV q6—8h
Alternative Regimen
Ampicillin 200 mg/kg/day IV q6—8h
AND
Gentamicin 2.5 mg/kg IV q8h
OR
Tobramycin2.5 mg/kg IV q8h
OR
Amikacin 10 mg/kg IV q8h
Age 1—23 Months
Preferred Regimen
Vancomycin 15 mg/kg IV q6 h
AND
Cefotaxime 225–300 mg/kg per day IV q6–8 h
OR
Ceftriaxone 80–100 mg/kg per day IV q12–24 h¤
Recurrent
Preferred Regimen
Vancomycin 30–60 mg/kg per day IV8–12 h
AND
Cefotaxime 8–12 g per day IVq4–6h
OR
▸'Ceftriaxone 2 g IV q12 h


¤Add amoxicillin or ampicillin if meningitis caused by L monocytogenes is also suspected. Ampicillin if meningitis caused by L monocytogenes is also suspected