Sandbox/v12

Community-Acquired Meningitis

Age <1 Week Preferred Regimen ▸ Ampicillin 50 mg/kg IV q8h AND ▸ Cefotaxime 100—150 mg/kg/day IV q8—12h Alternative Regimen ▸ Ampicillin 50 mg/kg IV q8h AND ▸ Gentamicin 2.5 mg/kg IV q12h Age 1—4 Weeks Preferred Regimen ▸ Ampicillin 200 mg/kg/day IV q6—8h AND ▸ Cefotaxime 150—200 mg/kg/day IV q6—8h Alternative Regimen ▸ Ampicillin 200 mg/kg/day IV q6—8h AND ▸ Gentamicin 2.5 mg/kg IV q8h OR ▸ Tobramycin 2.5 mg/kg IV q8h OR ▸ Amikacin 10 mg/kg IV q8h

Age 1—23 Months Preferred Regimen ▸ Vancomycin 15 mg/kg IV q6 h AND ▸ Cefotaxime 225–300 mg/kg per day IV q6–8 h OR ▸ Ceftriaxone 80–100 mg/kg per day IV q12–24 h¤ Age 2–50 years Preferred Regimen ▸ Children's dosage is as shown left,shown below is the adult ▸ Vancomycin 30–60 mg/kg per day IV8–12 h AND ▸ Cefotaxime 8–12 g per day IVq4–6h OR ▸ Ceftriaxone 2 g IV q12 h¤ Age >50 years Preferred Regimen ▸ Vancomycin 30–60 mg/kg per day IV8–12 h AND ▸ Cefotaxime 8–12 g per day IV q4–6h OR ▸'Ceftriaxone 2 g IV q12 h

Immunocompromised state Preferred Regimen ▸ Vancomycin 30–60 mg/kg per day IV 8–12 h AND ▸ Ampicillin 2 g IV q4 h AND ▸ Cefepime 2 g IV q8 h OR ▸Meropenem 2 g IV q8 h Recurrent Preferred Regimen ▸ Vancomycin 30–60 mg/kg per day IV8–12 h AND ▸ Cefotaxime 8–12 g per day IVq4–6h OR ▸'Ceftriaxone 2 g IV q12 h

^¤Add amoxicillin or ampicillin if meningitis caused by L monocytogenes is also suspected. Ampicillin if meningitis caused by L monocytogenes is also suspected