Thymoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2] Ahmad Al Maradni, M.D. [3]
Overview
Symptoms of thymoma include muscle weakness, cough, wheezing, and dysphagia in addition to the symptoms of associated immune syndromes such as anemia, arthralgia, and skin rash.
Signs and symptoms
Approximately 30% of patients with thymoma have symptoms caused by compression of the surrounding organs, these may include:[1]
- Facial swelling (due to compression of the upper caval vein)
- Dysphagia (due to compression of the esophagus)
- Cough and wheezing (due to compression of the trachea)
- Chest pain (due to local compression of the mass itself)
Approximately 30% of patients have symptoms of associated autoimmune disorders, these may include:
- Muscle weakness (associated with myasthenia gravis and polymyositis)
- Anemia (associated with pure red cell aplasia)
- Fever, chest pain, cough and malaise (associated with Good's syndrome, agranulocytosis, combined immunodeficiency, hypogammaglobulinemia and acute pericarditis)
- Arthralgia and skin rash (associated with polymyositis, scleroderma, rheumatoid arthritis and systemic lupus erythematosus)
- Anxiety, diarrhea and palpitation (associated with thyroiditis and ulcerative colitis)
Asymptomatic
Approximately 33% to 50% of patients with thymoma have no symptoms at all, and the mass is identified incidentally.[1]
References
- ↑ 1.0 1.1 Thomas CR, Wright CD, Loehrer PJ (1999). "Thymoma: state of the art". Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 17 (7): 2280–9. PMID 10561285. Retrieved 2012-01-18. Unknown parameter
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