Gliomatosis cerebri medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

The predominant therapy for gliomatosis cerebri is surgical resection. Adjunctive chemotherapy and radiation may be required.[1][2][3][4][5][6] Supportive therapy for gliomatosis cerebri includes anticonvulsants and corticosteroids.[7]

Medical Therapy

The predominant therapy for gliomatosis cerebri is surgical resection. Adjunctive chemotherapy and radiation may be required.[1][2][3][4][5][6] Supportive therapy for gliomatosis cerebri includes anticonvulsants and corticosteroids.[7]

1. Radiotherapy

  • Post-operative radiotherapy is recommended among all patients who develop gliomatosis cerebri.[1]
  • Radiotherapy may not cure the cancer but can control the tumor, delay recurrence, and increase survival.
  • Radiation therapy is associated with temporary improvement of clinical symptoms.[7]
  • External beam radiation therapy is preferred to whole brain radiotherapy.[2]
  • The median dose of radiation is 60 Gy (range: 50-72 Gy).[1]

2. Chemotherapy

3. Supportive treatment

References

  1. 1.0 1.1 1.2 1.3 Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T (2010). "Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases". Neurosurg Rev. 34 (2): 197–208. doi:10.1007/s10143-010-0306-1. PMID 21301914.
  2. 2.0 2.1 2.2 Hejazi N, Witzmann A, Hergan K (2001). "Gliomatosis cerebri: intra vitam stereotactic determination in two cases and review of the literature". Br J Neurosurg. 15 (5): 396–401. PMID 11708542.
  3. 3.0 3.1 3.2 Levin N, Gomori JM, Siegal T (2004). "Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide". Neurology. 63 (2): 354–6. PMID 15277636.
  4. 4.0 4.1 4.2 Sanson M, Napolitano M, Cartalat-Carel S, Taillibert S (2005). "[Gliomatosis cerebri]". Rev Neurol (Paris). 161 (2): 173–81. PMID 15798516.
  5. 5.0 5.1 5.2 Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB; et al. (2002). "Gliomatosis cerebri: molecular pathology and clinical course". Ann Neurol. 52 (4): 390–9. doi:10.1002/ana.10297. PMID 12325066.
  6. 6.0 6.1 6.2 Levin VA, Edwards MS, Wright DC, Seager ML, Schimberg TP, Townsend JJ; et al. (1980). "Modified procarbazine, CCNU, and vincristine (PCV 3) combination chemotherapy in the treatment of malignant brain tumors". Cancer Treat Rep. 64 (2–3): 237–44. PMID 7407756.
  7. 7.0 7.1 7.2 7.3 Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR (2012). "Presentation patterns and outcome of gliomatosis cerebri". Oncol Lett. 3 (1): 209–213. doi:10.3892/ol.2011.445. PMC 3362440. PMID 22740882.


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