Lymphocytic interstitial pneumonia: Difference between revisions
No edit summary |
No edit summary |
||
| Line 16: | Line 16: | ||
==Overview== | ==Overview== | ||
'''Lymphocytic interstitial pneumonia''' (also called '''lymphocytic interstitial pneumonitis''' or '''LIP''') is a syndrome secondary to [[autoimmune]] and other [[lymphoproliferative]] disorders. Symptoms include fever, cough, and shortness of breath. Lymphocytic interstitial pneumonia applies to a disorders associated with both, monoclonal or polyclonal [[gammopathy]].<ref>The Pathology of Idiopathic Interstitial Pneumonias Carol Farver, MD</ref> | '''Lymphocytic interstitial pneumonia''' (also called '''lymphocytic interstitial pneumonitis''' or '''LIP''') is a syndrome secondary to [[autoimmune]] and other [[lymphoproliferative]] disorders. Symptoms include fever, cough, and shortness of breath. Lymphocytic interstitial pneumonia applies to a disorders associated with both, monoclonal or polyclonal [[gammopathy]].<ref>The Pathology of Idiopathic Interstitial Pneumonias Carol Farver, MD</ref> | ||
== Causes == | |||
Possible causes of lymphocytic interstitial pneumonia include the [[Epstein-Barr virus]] and [[HIV|Human Immunodeficiency Virus]]. | |||
== Symptoms == | == Symptoms == | ||
These patients may present with | |||
*[[lymphadenopathy]], | |||
*[[Hepatemegaly]] Enlarged [[liver]], enlarged [[spleen]], enlarged [[salivary gland]], thickening and widening of the extremities of the fingers and toes, and breathing symptoms such as [[shortness of breath]] and wheezing. | |||
== Diagnosis == | == Diagnosis == | ||
| Line 25: | Line 30: | ||
[[Arterial]] blood gases may reveal [[hypoxemia]] when tested in a lab. [[Respiratory alkalosis]] may also be present.<ref>Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471</ref> Peripheral lymphocytosis can be observed. <ref>Pitt J. Lymphocytic interstitial pneumonia. Pediatr Clin N Am 1991;38:89-95.</ref>A lung biopsy may also be indicated.<ref>Strimlan CV, Rosenow EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonia. Review of 13 cases. Ann Intern Med 1978;88:616-621</ref> | [[Arterial]] blood gases may reveal [[hypoxemia]] when tested in a lab. [[Respiratory alkalosis]] may also be present.<ref>Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471</ref> Peripheral lymphocytosis can be observed. <ref>Pitt J. Lymphocytic interstitial pneumonia. Pediatr Clin N Am 1991;38:89-95.</ref>A lung biopsy may also be indicated.<ref>Strimlan CV, Rosenow EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonia. Review of 13 cases. Ann Intern Med 1978;88:616-621</ref> | ||
== Treatment == | == Treatment == | ||
Revision as of 20:04, 26 September 2011
| Lymphocytic interstitial pneumonia | |
| DiseasesDB | 31904 |
|---|---|
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Lymphocytic interstitial pneumonia (also called lymphocytic interstitial pneumonitis or LIP) is a syndrome secondary to autoimmune and other lymphoproliferative disorders. Symptoms include fever, cough, and shortness of breath. Lymphocytic interstitial pneumonia applies to a disorders associated with both, monoclonal or polyclonal gammopathy.[1]
Causes
Possible causes of lymphocytic interstitial pneumonia include the Epstein-Barr virus and Human Immunodeficiency Virus.
Symptoms
These patients may present with
- lymphadenopathy,
- Hepatemegaly Enlarged liver, enlarged spleen, enlarged salivary gland, thickening and widening of the extremities of the fingers and toes, and breathing symptoms such as shortness of breath and wheezing.
Diagnosis
Arterial blood gases may reveal hypoxemia when tested in a lab. Respiratory alkalosis may also be present.[2] Peripheral lymphocytosis can be observed. [3]A lung biopsy may also be indicated.[4]
Treatment
Patients presenting with no symptoms, and not affected by the syndrome may not require treatment. However, antibiotics are usually required for bacterial pulmonary infections. Bronchodilators may assist with breathing issues and resolution may occur with the use of Highly Active Anti-Retroviral Therapy. However, responses to different treatments are widely varied, and no single first line treatment represents the default treatment for lymphocytic interstitial pneumonia.[5]
References
- ↑ The Pathology of Idiopathic Interstitial Pneumonias Carol Farver, MD
- ↑ Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471
- ↑ Pitt J. Lymphocytic interstitial pneumonia. Pediatr Clin N Am 1991;38:89-95.
- ↑ Strimlan CV, Rosenow EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonia. Review of 13 cases. Ann Intern Med 1978;88:616-621
- ↑ Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471