Non-Hodgkin lymphoma (differentiating types of NHL): Difference between revisions
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! colspan="17" align="center" style="background:#7d7d7d; color: #FFFFFF;" + |Non-Hodgkin's Lymphoma | ! colspan="17" align="center" style="background:#7d7d7d; color: #FFFFFF;" + |Non-Hodgkin's Lymphoma | ||
|- | |- | ||
! | | | ||
! colspan="2" align="center" style="background:#DCDCDC;" + |[[Diffuse large B cell lymphoma]] | |||
| align="left" style="background:#F5F5F5;" + | | |||
* Mature B-cell Lymphoma | |||
* 8q24/''MYC'' [[translocations]] | |||
* Hypermutated immunoglobulin genes | |||
* Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]'' /''TTFn'', ''[[TP53]]'' genes | |||
* Translocations involving ''c-MYC'', ''BCL6'', and ''IgH'' gene. | |||
| align="left" style="background:#F5F5F5;" + | | | align="left" style="background:#F5F5F5;" + | | ||
* | * Fever | ||
* | * Night sweats | ||
* | * weight loss | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Painless rapidly enlarging [[lymph nodes]] | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + |↓ | | align="center" style="background:#F5F5F5;" + |↓ | ||
| align="center" style="background:#F5F5F5;" + |↓ | | align="center" style="background:#F5F5F5;" + |↓ | ||
| align="center" style="background:#F5F5F5;" + |Nl to ↓ | | align="center" style="background:#F5F5F5;" + |Nl to ↓ | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* | | align="left" style="background:#F5F5F5;" + | | ||
* | '''Centroblastic''' | ||
*Medium-to-large-sized [[Lymphocyte|lymphocytes]] | |||
*Monomorphic | |||
'''Immunoblastic''' | |||
*> 90% immunoblasts | |||
*Trapezoid shaped large lymphoid cells with significant [[basophilic]] cytoplasm | |||
'''Anaplastic''' | |||
*Very large cells with a round, oval, or polygonal shape that may resemble Reed-Sternberg cells | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
|- | |- | ||
! rowspan="10" |B Cell Lymphoma | |||
! colspan="2" align="center" style="background:#DCDCDC;" + |Mantle cell lymphoma | ! colspan="2" align="center" style="background:#DCDCDC;" + |Mantle cell lymphoma | ||
| align="left" style="background:#F5F5F5;" + | | | align="left" style="background:#F5F5F5;" + | | ||
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|- | |- | ||
! colspan="2" align="center" style="background:#DCDCDC;" + | | ! colspan="2" align="center" style="background:#DCDCDC;" + |B-lymphoblastic leukemia/lymphoma | ||
| align="left" style="background:#F5F5F5;" + | | | align="left" style="background:#F5F5F5;" + | | ||
* | * Precursor B-cell Lymphoma | ||
* | *Unknown | ||
* | *Inherited mutations of PAX5, ETV6, and TP53 | ||
| align="center" style="background:#F5F5F5;" + | + | |||
| align="center" style="background:#F5F5F5;" + |– | |||
| align=" | | align="center" style="background:#F5F5F5;" + |– | ||
| align="center" style="background:#F5F5F5;" + |– | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Bleeding | |||
*[[Dyspnea]] | |||
*Joint pain | |||
| align="center" style="background:#F5F5F5;" + |↓ | |||
| align="center" style="background:#F5F5F5;" + |↓ | |||
| align="center" style="background:#F5F5F5;" + |Nl to ↓ | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Down syndrome | |||
|- | |||
! colspan="2" align="center" style="background:#DCDCDC;" + |[[Follicular lymphoma]] | |||
| align="left" style="background:#F5F5F5;" + | | |||
* Mature B-cell Lymphoma | |||
* Reciprocal translocation t(14;18) | |||
* Overexpression of ''BCL2'' | |||
| align="left" style="background:#F5F5F5;" + |Only in 20% of patients: | |||
*[[Fever]] | |||
*[[Weight loss]] | |||
*[[Night sweats]] | |||
| align="center" style="background:#F5F5F5;" + | + | |||
| align="center" style="background:#F5F5F5;" + | + | |||
| align="center" style="background:#F5F5F5;" + |± | |||
| align="left" style="background:#F5F5F5;" + | | |||
* Painless peripheral adenopathy in the cervical, axillary, inguinal, and/or femoral regions | |||
* Asymptomatic large abdominal mass | |||
| align="left" style="background:#F5F5F5;" + | | |||
* [[Seizures]] | |||
*[[Chest pain]] | |||
*[[Bone pain]] | |||
*[[Cough]] | |||
*[[Dyspnea]] | |||
| align="center" style="background:#F5F5F5;" + |↓ | | align="center" style="background:#F5F5F5;" + |↓ | ||
| align="center" style="background:#F5F5F5;" + |↓ | | align="center" style="background:#F5F5F5;" + |↓ | ||
| align="center" style="background:#F5F5F5;" + |Nl to ↓ | | align="center" style="background:#F5F5F5;" + |Nl to ↓ | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* CD21 | |||
* CD23 | |||
* | |||
* | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Nodular growth pattern | |||
| align="center" style="background:#F5F5F5;" + |Lymph node biopsy | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Most common clinically indolent NHL | |||
* Peripheral nerve compression | |||
|- | |- | ||
! colspan="2" align="center" style="background:#DCDCDC;" + |[[Burkitt lymphoma]] | ! colspan="2" align="center" style="background:#DCDCDC;" + |[[Burkitt lymphoma]] | ||
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|- | |- | ||
! | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Category | ||
! colspan="2" | ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease | ||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Etiology | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Etiology | ||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Constitutional symptoms | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Constitutional symptoms | ||
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! align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated findings | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated findings | ||
|- | |- | ||
! rowspan="10" | ! rowspan="10" align="center" style="background:#4479BA; color: #FFFFFF;" + |T cell lymphoma | ||
! colspan="2" align="center" style="background:#DCDCDC;" + |Precursor T-cell lymphoblastic leukemia/lymphoma | ! colspan="2" align="center" style="background:#DCDCDC;" + |Precursor T-cell lymphoblastic leukemia/lymphoma | ||
| align="left" style="background:#F5F5F5;" + | | | align="left" style="background:#F5F5F5;" + | |
Revision as of 15:01, 18 January 2019
Non-Hodgkin lymphoma Microchapters |
Differentiating Non-Hodgkin's Lymphoma |
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Non-Hodgkin lymphoma (differentiating types of NHL) On the Web |
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Non-Hodgkin lymphoma (differentiating types of NHL) in the news |
Blogs on Non-Hodgkin lymphoma (differentiating types of NHL) |
Risk calculators and risk factors for Non-Hodgkin lymphoma (differentiating types of NHL) |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Non-Hodgkin lymphoma (differentiating types of NHL)
Differentiating different types of Non-Hodgkin lymphoma.
Category | Disease | Etiology | Clinical manifestations | Paraclinical findings | Gold standard | Associated findings | ||||||||||
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Lab findings | ||||||||||||||||
Symptoms | Signs | CBC | Immunochemistry | Histopathology | ||||||||||||
Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | ||||||||
Hodgkin's Lymphoma | ||||||||||||||||
Non-Hodgkin's Lymphoma | ||||||||||||||||
Diffuse large B cell lymphoma |
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↓ | ↓ | Nl to ↓ |
Centroblastic
Immunoblastic
Anaplastic
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B Cell Lymphoma | Mantle cell lymphoma |
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Abdominal distention |
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↓ | Nl to ↓ |
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B-lymphoblastic leukemia/lymphoma |
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+ | – | – | – |
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↓ | ↓ | Nl to ↓ |
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Follicular lymphoma |
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Only in 20% of patients: | + | + | ± |
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↓ | ↓ | Nl to ↓ |
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Lymph node biopsy |
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Burkitt lymphoma |
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B cell chronic lymphocytic leukemia/small lymphocytic lymphoma |
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Marginal zone lymphoma | Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type |
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Splenic marginal zone lymphoma |
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Nodal marginal zone B-cell lymphoma |
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+ |
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Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia) |
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Hairy cell leukemia |
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Category | Disease | Etiology | Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | Immunochemistry | Histopathology | Gold standard | Associated findings | |
T cell lymphoma | Precursor T-cell lymphoblastic leukemia/lymphoma |
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Adult T cell leukemia/lymphoma |
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Anaplastic large cell lymphoma |
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Cutaneous T-cell lymphoma | Mycosis fungoides / Sézary syndrome |
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Peripheral T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma |
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Hepatosplenic gamma-delta T-cell lymphoma |
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Enteropathy-type intestinal T-cell lymphoma |
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Extranodal T-cell lymphoma, nasal type |
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Angioimmunoblastic T-cell lymphoma |
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Peripheral T-cell lymphoma, unspecified |
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