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==Historical Perspective==
==Historical Perspective==
Cretinism was first described by ancient Roman writers. Cretinism was described by physicians and travelers in the 19th century and some areas in Europe and North America were named as "goiter belts".


==Classification==
==Classification==
Cretinism may be classified into two groups which are transient and permanent cretinism. Permanent cretinism can be more classified into primary and secondary subtypes.


==Pathophysiology==
==Pathophysiology==

Revision as of 00:16, 8 September 2017

Cretinism Microchapters

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Historical Perspective

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Causes

Differentiating Cretinism from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cretinism is a condition of severely stunted physical and mental growth due to untreated congenital deficiency of thyroid hormones (hypothyroidism). The term cretin refers to a person so affected. Cretinism is an old name used for congenital hypothyroidism. It includes sporadic cretinism and endemic cretinism. Sporadic cretinism is caused by gene mutations, radiation, drugs and so on. Usual symptoms are neurological impairment, low metabolism conditions and infertility. Thyroid hormone replacement is the main treatment. Endemic cretinism results from a diet deficient in iodine. Iodine deficiency results in enlargement of the thyroid gland, physical development hypoevolutism and mental development impairment. As a public health problem, many countries have established the policy of iodine administration.

Historical Perspective

Cretinism was first described by ancient Roman writers. Cretinism was described by physicians and travelers in the 19th century and some areas in Europe and North America were named as "goiter belts".

Classification

Cretinism may be classified into two groups which are transient and permanent cretinism. Permanent cretinism can be more classified into primary and secondary subtypes.

Pathophysiology

Causes

Differentiating Cretinism from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Surgery

Medical Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

References


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