Non-Hodgkin lymphoma (differentiating types of NHL): Difference between revisions
Preeti Singh (talk | contribs) No edit summary |
Preeti Singh (talk | contribs) No edit summary |
||
Line 37: | Line 37: | ||
|- | |- | ||
! align="center" style="background:#4479BA; color: #FFFFFF;" + | | ! align="center" style="background:#4479BA; color: #FFFFFF;" + | | ||
! colspan="2" align="center" style="background:#DCDCDC;" color: #FFFFFF;" + |[[Hodgkin's lymphoma|Hodgkin's Lymphoma]] | ! colspan="2" align="center" style="background:#DCDCDC;" color: #FFFFFF;" + |[[Hodgkin's lymphoma|Hodgkin's Lymphoma]]<ref name="pmid11238088">{{cite journal| author=Buri C, Körner M, Schärli P, Cefai D, Uguccioni M, Mueller C et al.| title=CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease. | journal=Blood | year= 2001 | volume= 97 | issue= 6 | pages= 1543-8 | pmid=11238088 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11238088 }}</ref><ref name="pmid28082443">{{cite journal| author=Zahn M, Marienfeld R, Melzner I, Heinrich J, Renner B, Wegener S et al.| title=A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells. | journal=Blood | year= 2017 | volume= 129 | issue= 11 | pages= 1480-1490 | pmid=28082443 | doi=10.1182/blood-2016-06-720516 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28082443 }}</ref> | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Activation of (NF-kB) | |||
* Mutations in JAK-STAT pathway | |||
* NF-kB leads to activation of many genes like: | |||
**[[ICAM-1|(ICAM-1) gene]] | |||
**[[Granulocyte macrophage colony stimulating factor|GM-CSF gene]] | |||
**[[Interleukin 6|IL-6 gene]] | |||
**IKBA gene | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
Line 49: | Line 57: | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* [[CD45]]- | |||
* [[CD30]]+ | |||
* [[CD15]]+/- i | |||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* [[EBV infection]] | |||
|- | |- | ||
! colspan="16" align="center" style="background:#7d7d7d; color: #FFFFFF;" + |Non-Hodgkin's Lymphoma | ! colspan="16" align="center" style="background:#7d7d7d; color: #FFFFFF;" + |Non-Hodgkin's Lymphoma |
Revision as of 16:20, 18 January 2019
Non-Hodgkin lymphoma Microchapters |
Differentiating Non-Hodgkin's Lymphoma |
---|
Treatment |
Case Studies |
Non-Hodgkin lymphoma (differentiating types of NHL) On the Web |
American Roentgen Ray Society Images of Non-Hodgkin lymphoma (differentiating types of NHL) |
Non-Hodgkin lymphoma (differentiating types of NHL) in the news |
Blogs on Non-Hodgkin lymphoma (differentiating types of NHL) |
Risk calculators and risk factors for Non-Hodgkin lymphoma (differentiating types of NHL) |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Non-Hodgkin lymphoma (differentiating types of NHL)
Differentiating different types of Non-Hodgkin lymphoma. Gold standard for differentiation different types of Non-Hodgkin lymphoma is Biopsy.
Category | Disease | Etiology | Clinical manifestations | Paraclinical findings | Associated findings | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lab findings | |||||||||||||||
Symptoms | Signs | CBC | Immunochemistry | Histopathology | |||||||||||
Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | |||||||
Hodgkin's Lymphoma[1][2] |
|
||||||||||||||
Non-Hodgkin's Lymphoma | |||||||||||||||
Diffuse large B cell lymphoma |
|
|
- | + | + |
|
|
↓ | ↓ | Nl to ↓ |
|
Centroblastic
Immunoblastic
Anaplastic
|
|||
B Cell Lymphoma | Mantle cell lymphoma |
|
|
Abdominal distention |
|
|
|
↓ | Nl to ↓ |
|
|
||||
B-lymphoblastic leukemia/lymphoma |
|
+ | – | – | – |
|
↓ | ↓ | Nl to ↓ |
| |||||
Follicular lymphoma |
|
Only in 20% of patients: | + | + | ± |
|
↓ | ↓ | Nl to ↓ |
|
|
| |||
Burkitt lymphoma |
|
|
|
|
|||||||||||
B cell chronic lymphocytic leukemia/small lymphocytic lymphoma |
|
||||||||||||||
Marginal zone lymphoma | Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type |
|
|||||||||||||
Splenic marginal zone lymphoma |
|
|
|||||||||||||
Nodal marginal zone B-cell lymphoma |
|
+ |
|
|
| ||||||||||
Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia) |
|
||||||||||||||
Hairy cell leukemia |
|
|
|
||||||||||||
Category | Disease | Etiology | Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | Immunochemistry | Histopathology | Associated findings | |
T cell lymphoma | Precursor T-cell lymphoblastic leukemia/lymphoma |
|
|||||||||||||
Adult T cell leukemia/lymphoma |
|
||||||||||||||
Anaplastic large cell lymphoma |
|
||||||||||||||
Cutaneous T-cell lymphoma | Mycosis fungoides / Sézary syndrome |
|
|
|
|||||||||||
Peripheral T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma |
|
|||||||||||||
Hepatosplenic gamma-delta T-cell lymphoma |
|
||||||||||||||
Enteropathy-type intestinal T-cell lymphoma |
|
||||||||||||||
Extranodal T-cell lymphoma, nasal type |
|
||||||||||||||
Angioimmunoblastic T-cell lymphoma |
|
||||||||||||||
Peripheral T-cell lymphoma, unspecified |
|
- ↑ Buri C, Körner M, Schärli P, Cefai D, Uguccioni M, Mueller C; et al. (2001). "CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease". Blood. 97 (6): 1543–8. PMID 11238088.
- ↑ Zahn M, Marienfeld R, Melzner I, Heinrich J, Renner B, Wegener S; et al. (2017). "A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells". Blood. 129 (11): 1480–1490. doi:10.1182/blood-2016-06-720516. PMID 28082443.