Oligoastrocytoma overview: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Oligoastrocytoma}} | {{Oligoastrocytoma}} | ||
{{CMG}}{{AE}}{{SR}} | |||
* {{CMG}}{{AE}}{{SR}} | |||
==Overview== | ==Overview== | ||
Oligoastrocytomas are | Oligoastrocytomas are extremely rare brain tumors that together with [[oligodendrogliomas]] account for approximately 10% of primary [[CNS]] tumors. They are a subtype of gliomas and account for 25% of all [[gliomas]]. These tumors are composed of [[astrocytoma]] and [[oligodendroglioma]]. Celli et al in 1994 gave the name of "oligoastrocytoma" to those oligodendroglial tumors where the [[astrocytes]] formed more than 20% of the tumor cells. Morphologic characteristics of oligoastrocytomas resemble those of pure oligodendrogliomas and astrocytomas. Oligoastrocytomas are primarily tumors of adulthood with peak incidence in 4th to 6th decade of life. Even though these tumors can arise anywhere within the the brain, but usually in the [[supratentorial]] region, especially [[frontal]] and [[temporal]] lobes are the most common sites. Based on WHO classification, oligoastrocytomas are devided into two classes: oligoastrocytoma corresponding to grade II and anaplastic oligoastrocytoma corresponding to grade III. Clinical manifestaions of oligoastrocytoma vary and can range from seizure and headaches to personality changes. Many risk fators seem to play a role in pathogenesis of oligoastrocytoma. The molecular changes can resemble those of oligodendrogliomas (loss of heterozygosity on 1p and 19q, in 30-70% of cases) or astrocytoma (TP53 mutation and loss of heterozygosity on 17p). Treatment is based on sugery, however the tumor is responsive to chemotherapy in most cases, when necessary. | ||
==Historical Perspective== | ==Historical Perspective== | ||
The broad topic "oligodendroglial tumors", of which oligoastrocytoma is a part of, was first described by Bailey and Cushing in 1926. They reported that gliomas were formed by transformation of glial cells. | The broad topic "oligodendroglial tumors", of which oligoastrocytoma is a part of, was first described by Bailey and Cushing in 1926. They reported that gliomas were formed by transformation of glial cells.Celli et al in 1994 gave the name of "oligoastrocytoma" to those oligodendroglial tumors where the [[astrocytes]] formed more than 20% of the tumor cells. | ||
==Classification== | ==Classification== | ||
Oligoastrocytoma may be classified according to the WHO classification of the central nervous system tumors into two subtypes: oligoastrocytoma (OAII) and [[oligoastrocytoma|anaplastic oligoastrocytoma]] (OAIII). | Oligoastrocytoma may be classified according to the WHO classification of the central nervous system tumors into two subtypes: oligoastrocytoma (OAII) and [[oligoastrocytoma|anaplastic oligoastrocytoma]] (OAIII). OAII can evolve to OAIII overtime. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Oligoastrocytomas are mixed tumors that | Oligoastrocytomas are mixed tumors that arise from the proliferation of both [[oligodendrocyte]]s and [[astrocyte]]s. Genes associated with the pathogenesis of oligoastrocytoma and anaplastic oligoastrocytoma include ''[[Isocitrate dehydrogenase|IDH1]]'', ''[[p53]]'', ''[[EGFR]]'', ''[[ATRX]]'', ''[[EGFR]]'', ''[[PTEN]]'', ''[[Ogt|MGMT]]'', ''CIC'', and ''[[Far upstream element-binding protein 1|FUBP1]]''. 30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of [[chromosome 1|1p]] and [[chromosome 19|19q]]. | ||
* | |||
==Causes== | ==Causes== | ||
Common causes of oligoastrocytoma include [[mutation|genetic mutations]]. Common genetic mutations involved in the development of oligoastrocytoma can be found [[Oligoastrocytoma pathophysiology|'''here''']]. | Common causes of oligoastrocytoma include [[mutation|genetic mutations]] and ionizing radiation. Common genetic mutations involved in the development of oligoastrocytoma can be found [[Oligoastrocytoma pathophysiology|'''here''']]. Genes associated with the pathogenesis of oligoastrocytoma and anaplastic oligoastrocytoma include ''[[Isocitrate dehydrogenase|IDH1]]'', ''[[p53]]'', ''[[EGFR]]'', ''[[ATRX]]'', ''[[EGFR]]'', ''[[PTEN]]'', ''[[Ogt|MGMT]]'', ''CIC'', and ''[[Far upstream element-binding protein 1|FUBP1]]''. | ||
==Differentiating Oligodendroglioma from other diseases== | ==Differentiating Oligodendroglioma from other diseases== | ||
As clinical manifestation of oligoastrocytoma differ based on the site of the tumor, many disease and intracranial space occupying lesions can be named as its differential diagnosis: [[Astrocytoma]], [[Anaplastic|anaplastic astrocytoma]], [[oligodendroglioma]], [[pilocytic astrocytoma]], [[Adult brain tumors classification|central neurocytoma]][[ependymoma|, ependymoma,]] [[dysembryoplastic neuroepithelial tumor]], [[meningioma]], [[metastasis|cerebral metastasis]], [[multiple sclerosis]], and intracranial cysts. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Oligoastrocytoma is the third most common glioma. | Oligoastrocytoma is the third most common glioma. Oligoastrocytoma accounts for 1% of all [[brain tumors]] and 5–10% of all [[glioma|glial neoplasms]]. The incidence of oligoastrocytoma is approximately 0.03 per 100,000 individuals in the United States. Oligoastrocytoma is a disease that tends to affect the young and middle-aged adult population with peak incidence in 4th to 6th decades of life. The median age of diagnosis is 42 years. Males are more commonly affected with oligoastrocytoma than females. Oligoastrocytoma usually affects individuals of the Caucasian race. The incidence rate of oligoastrocytoma is higher in developed countries than in developing countries. | ||
==Risk factors== | ==Risk factors== | ||
Common risk factors in the development of oligoastrocytoma include [[family history]] of [[brain tumors]], [[radiation|ionizing radiation]], [[allergy|allergic diseases]] | Common risk factors in the development of oligoastrocytoma include [[family history]] of [[brain tumors]], [[radiation|ionizing radiation]], and [[allergy|allergic diseases]]. However other risk factors such as viral infections and immune factors seem to play a role. Of these factors, only the association of ionizing radiation has been proven. | ||
==Screening== | ==Screening== | ||
There is insufficient evidence to recommend routine screening for oligoastrocytoma. | There is insufficient evidence to recommend routine screening for oligoastrocytoma. | ||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
If left untreated, patients with oligoastrocytoma may progress to develop [[seizures]], focal neurological deficits, [[hydrocephalus]], [[brain herniation]], [[intracranial hemorrhage]], and ultimately death.<ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="Grier2006">{{cite journal|last1=Grier|first1=J. T.|title=Low-Grade Gliomas in Adults|journal=The Oncologist|volume=11|issue=6|year=2006|pages=681–693|issn=1083-7159|doi=10.1634/theoncologist.11-6-681}}</ref><ref name="pmid3748360">{{cite journal| author=Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC et al.| title=Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. | journal=Neurosurgery | year= 1986 | volume= 19 | issue= 2 | pages= 278-81 | pmid=3748360 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3748360 }} </ref> Oligoastrocytomas are slow growing tumors.<ref name=pathoOA1>{{cite book | last = Adesina | first = Adekunle | title = Atlas of pediatric brain tumors | publisher = Springer | location = New York | year = 2010 | isbn = 9781441910622 }}</ref> Common complications associated with oligoastrocytoma include [[hydrocephalus]], [[intracranial hemorrhage]], [[coma]], [[metastasis]], [[venous thromboembolism]], and side effects of [[chemotherapy]] and [[radiation]].<ref name="Grier2006">{{cite journal|last1=Grier|first1=J. T.|title=Low-Grade Gliomas in Adults|journal=The Oncologist|volume=11|issue=6|year=2006|pages=681–693|issn=1083-7159|doi=10.1634/theoncologist.11-6-681}}</ref><ref name="pmid20555079">{{cite journal| author=Stupp R, Tonn JC, Brada M, Pentheroudakis G, ESMO Guidelines Working Group| title=High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. | journal=Ann Oncol | year= 2010 | volume= 21 Suppl 5 | issue= | pages= v190-3 | pmid=20555079 | doi=10.1093/annonc/mdq187 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20555079 }} </ref><ref name=wikiglioss1>Signs and symptoms of glioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Glioma. Accessed on October 20, 2015</ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="pmid9663425">{{cite journal| author=Finsterer J, Breiteneder S, Mueller MR, Wogritsch C, Vesely M, Kleinert R et al.| title=Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. | journal=Oncology | year= 1998 | volume= 55 | issue= 4 | pages= 345-8 | pmid=9663425 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9663425 }} </ref><ref name="pmid3748360">{{cite journal| author=Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC et al.| title=Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. | journal=Neurosurgery | year= 1986 | volume= 19 | issue= 2 | pages= 278-81 | pmid=3748360 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3748360 }} </ref> Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligoastrocytoma may vary. However, the prognosis is generally regarded as good.<ref name="pmid16018821">{{cite journal| author=Liang Y, Bollen AW, Nicholas MK, Gupta N| title=Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. | journal=BMC Clin Pathol | year= 2005 | volume= 5 | issue= | pages= 6 | pmid=16018821 | doi=10.1186/1472-6890-5-6 | pmc=PMC1182359 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16018821 }} </ref> The prognosis | |||
* If left untreated, patients with oligoastrocytoma may progress to develop [[seizures]], focal neurological deficits, [[hydrocephalus]], [[brain herniation]], [[intracranial hemorrhage]], and ultimately death.<ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="Grier2006">{{cite journal|last1=Grier|first1=J. T.|title=Low-Grade Gliomas in Adults|journal=The Oncologist|volume=11|issue=6|year=2006|pages=681–693|issn=1083-7159|doi=10.1634/theoncologist.11-6-681}}</ref><ref name="pmid3748360">{{cite journal| author=Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC et al.| title=Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. | journal=Neurosurgery | year= 1986 | volume= 19 | issue= 2 | pages= 278-81 | pmid=3748360 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3748360 }} </ref> | |||
* Oligoastrocytomas are slow growing tumors.<ref name="pathoOA1">{{cite book | last = Adesina | first = Adekunle | title = Atlas of pediatric brain tumors | publisher = Springer | location = New York | year = 2010 | isbn = 9781441910622 }}</ref> | |||
* These tumors can evolve in terms of WHO classification from OAII to OAIII over time. | |||
* Common complications associated with oligoastrocytoma include [[hydrocephalus]], [[intracranial hemorrhage]], [[coma]], [[metastasis]], [[venous thromboembolism]], and side effects of [[chemotherapy]] and [[radiation]].<ref name="Grier2006">{{cite journal|last1=Grier|first1=J. T.|title=Low-Grade Gliomas in Adults|journal=The Oncologist|volume=11|issue=6|year=2006|pages=681–693|issn=1083-7159|doi=10.1634/theoncologist.11-6-681}}</ref><ref name="pmid20555079">{{cite journal| author=Stupp R, Tonn JC, Brada M, Pentheroudakis G, ESMO Guidelines Working Group| title=High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. | journal=Ann Oncol | year= 2010 | volume= 21 Suppl 5 | issue= | pages= v190-3 | pmid=20555079 | doi=10.1093/annonc/mdq187 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20555079 }} </ref><ref name="wikiglioss1">Signs and symptoms of glioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Glioma. Accessed on October 20, 2015</ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="pmid9663425">{{cite journal| author=Finsterer J, Breiteneder S, Mueller MR, Wogritsch C, Vesely M, Kleinert R et al.| title=Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. | journal=Oncology | year= 1998 | volume= 55 | issue= 4 | pages= 345-8 | pmid=9663425 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9663425 }} </ref><ref name="pmid3748360">{{cite journal| author=Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC et al.| title=Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. | journal=Neurosurgery | year= 1986 | volume= 19 | issue= 2 | pages= 278-81 | pmid=3748360 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3748360 }} </ref> | |||
* Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligoastrocytoma may vary. However, the prognosis is generally regarded as good.<ref name="pmid16018821">{{cite journal| author=Liang Y, Bollen AW, Nicholas MK, Gupta N| title=Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. | journal=BMC Clin Pathol | year= 2005 | volume= 5 | issue= | pages= 6 | pmid=16018821 | doi=10.1186/1472-6890-5-6 | pmc=PMC1182359 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16018821 }} </ref> | |||
* The prognosis of low-grade oligoastrocytoma is more favorable than that for anaplastic oligoastrocytoma because of the more indolent course and younger age at which most patients are diagnosed.<ref name="Grier2006">{{cite journal|last1=Grier|first1=J. T.|title=Low-Grade Gliomas in Adults|journal=The Oncologist|volume=11|issue=6|year=2006|pages=681–693|issn=1083-7159|doi=10.1634/theoncologist.11-6-681}}</ref> | |||
* The prognosis of oligoastrocytoma is better than that of astrocytoma and poorer than that of oligodendrogliomas. | |||
* The 1, 5, and 10-year survival rates of patients with oligoastrocytoma are approximately 87%, 56.97%, and 45.80%, respectively.<ref name="cbtrus3"> One–, Two–, Three–, Four–, Five–, and 10–year relative survival rates for selected malignant brain and central nervous system tumors, Seer 17 Registries, 1995-2006. CBTRUS 2015. http://www.cbtrus.org/2010-NPCR-SEER/CBTRUS-WEBREPORT-Final-3-2-10.pdf. Accessed on October 16, 2015</ref> | |||
==Diagnosis== | ==Diagnosis== | ||
* Histopathologic examination remains the gold standard for diagnosis of oligoastrocytoma. | |||
* On gross pathology, oligoastrocytoma is characterized by a soft, well-defined, grey-tan, mucoid or hemorrhagic, calcified mass with or without necrosis, which may expand the [[gyrus]] and cause blurring of the grey-white junction.<ref name="pathoOA1" /> | |||
* In histopathologic examination: | |||
*Oligoastrocytoma is characterized by [[Cell|highly cellular lesions]] composed of both [[oligodendrocyte|oligodendroglial]] and [[astrocyte|astrocytic]] components.<ref name="patho1">Pathology of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 16, 2015</ref><ref name="pmid15026604">{{cite journal| author=Naugle DK, Duncan TD, Grice GP| title=Oligoastrocytoma. | journal=Radiographics | year= 2004 | volume= 24 | issue= 2 | pages= 598-600 | pmid=15026604 | doi=10.1148/rg.242035069 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15026604 }} </ref><ref name="pathowiki">Pathology of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 16, 2015</ref><ref name="bookneuropathologyoligoastro">{{Citation| last1 = Love| first1 = S.| last2 = Loius| first2 = D.| last3 = Ellison| first3 = D.W.| lastauthoramp = yes| title = Greenfield's neuropathology| publisher = Hodder Arnold| place = Boca Raton, Florida| volume = 1| edition = 8th| year = 2008}}</ref><ref name="histoOA">Histology of anaplastic oligoastrocytes. Dr. Frank Gaillard. Radiopaedia 2015. http://radiopaedia.org/cases/anaplastic-oligoastrocytoma. Accessed on October 19, 2015</ref> | |||
*In addition to the histological features of oligoastrocytoma, [[anaplastic|anaplastic oligoastrocytoma]] also has significant or brisk [[mitoses|mitotic activity]], marked [[atypia|cytologic and nuclear atypia]], [[necrosis]], [[apoptosis]], and microvacular proliferation.<ref name="patho1" /><ref name="pmid15026604" /><ref name="pathowiki" /> | |||
*Oligoastrocytoma is demonstrated by positivity to tumor markers such as [[Microtubule-associated protein|MAP2]], [[GFAP]](due to presence of reactive astrocytes), [[isocitrate dehydrogenase|IDH1]], [[OLIG1|OLIG-1 protein]], [[OLIG2|OLIG-2 protein]], and [[AIF1|Iba-2 protein]].<ref name="IHC">IHC of oligoastrocytoma. Librepathology 2015. http://librepathology.org/wiki/index.php/Oligoastrocytoma. Accessed on October 16, 2015</ref><ref name="pmid22821367">{{cite journal| author=Kolenda-Roberts HM, Harris N, Singletary E, Hardisty JF| title=Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat. | journal=Toxicol Pathol | year= 2013 | volume= 41 | issue= 1 | pages= 98-108 | pmid=22821367 | doi=10.1177/0192623312452492 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22821367 }} </ref><ref name="pmid16018821" /><ref name="Grier2006" /><ref name="pathoOA1" /> | |||
==Staging== | ==Staging== | ||
There is no established system for the staging of oligoastrocytoma.<ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> | There is no established system for the staging of oligoastrocytoma.<ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> | ||
==History and Symptoms== | ==History and Symptoms== | ||
When evaluating a patient for oligoastrocytoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough past medical history review. Other specific areas of focus when obtaining the history include review of the history of any ionizing [[radiation]], [[Allergy|allergic diseases]] | When evaluating a patient for oligoastrocytoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough past medical history review. Other specific areas of focus when obtaining the history include review of the history of any ionizing [[radiation]], [[Allergy|allergic diseases]], and the [[family history]] for any [[brain tumors]].<ref name="pmid21149253">{{cite journal| author=McCarthy BJ, Rankin KM, Aldape K, Bondy ML, Brännström T, Broholm H et al.| title=Risk factors for oligodendroglial tumors: a pooled international study. | journal=Neuro Oncol | year= 2011 | volume= 13 | issue= 2 | pages= 242-50 | pmid=21149253 | doi=10.1093/neuonc/noq173 | pmc=PMC3064625 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21149253 }} </ref><ref name="pmid19216998">{{cite journal| author=Terry MB, Howe G, Pogoda JM, Zhang FF, Ahlbom A, Choi W et al.| title=An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group. | journal=Ann Epidemiol | year= 2009 | volume= 19 | issue= 3 | pages= 161-71 | pmid=19216998 | doi=10.1016/j.annepidem.2008.12.010 | pmc=PMC3832293 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19216998 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> Symptoms associated with oligoastrocytoma include [[seizure]], [[headache]], [[nausea]], [[vomiting]], [[Ataxia|loss of balance]], [[vision loss]], and changes in [[Dysarthria|speech]], [[mood disorders|mood]], and [[personality pathology|personality]].<ref name="symptomwiki">Symptoms of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 16, 2015</ref><ref name="pmid15026604">{{cite journal| author=Naugle DK, Duncan TD, Grice GP| title=Oligoastrocytoma. | journal=Radiographics | year= 2004 | volume= 24 | issue= 2 | pages= 598-600 | pmid=15026604 | doi=10.1148/rg.242035069 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15026604 }} </ref><ref name="wikiOA1">Symptoms of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015</ref><ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="wikiglioss1">Signs and symptoms of glioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Glioma. Accessed on October 20, 2015</ref><ref name="OAsymp2">Symptoms of oligoastrocytoma. American Brain Tumor Association 2015. http://www.abta.org/secure/oligodendrioma-oligo.pdf. Accessed on October 21, 2015</ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> | ||
==Physical examination== | ==Physical examination== | ||
Common physical examination findings of oligoastrocytoma include [[nystagmus]] | Common physical examination findings of oligoastrocytoma include: | ||
* [[nystagmus]] | |||
* [[papilledema]] | |||
* [[esotropia]] | |||
* [[vision loss|visual field loss]] | |||
* [[altered mental status]] | |||
* focal neurological deficits.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
| Line 50: | Line 76: | ||
==CT== | ==CT== | ||
Head CT scan may be helpful in the diagnosis of oligoastrocytoma. Findings on CT scan suggestive of oligoastrocytoma are intra-axial low-attenuation areas with mass effect and little to no associated [[edema]].<ref name=radioct>Radiologic features of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 18, 2015</ref> | |||
* Head CT scan may be helpful in the diagnosis of oligoastrocytoma, however it lacks the required specificity for definitive diagnosis. | |||
* The findings on CT scan have unsharp edges and appear as patchy lesions. | |||
* Tumors may show areas of calcification in CT scan. | |||
* Findings on CT scan suggestive of oligoastrocytoma are intra-axial low-attenuation areas with mass effect and little to no associated [[edema]].<ref name="radioct">Radiologic features of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 18, 2015</ref> | |||
==MRI== | ==MRI== | ||
Brain MRI is helpful in the diagnosis of oligoastrocytoma. On brain MRI, oligoastrocytoma is characterized by a mass which is typically hypointense on T1-weighted images and hyperintense on T2-weighted images. No enhancement is observed on gadolinium enhanced T1-weighted images.<ref name=radioMRI>Radiologic MRI features of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma</ref> | |||
* Brain MRI is helpful in the diagnosis of oligoastrocytoma. | |||
* On brain MRI, oligoastrocytoma is characterized by a mass which is typically hypointense on T1-weighted images and hyperintense on T2-weighted images. | |||
* No enhancement is observed on gadolinium enhanced T1-weighted images.<ref name="radioMRI">Radiologic MRI features of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma</ref> | |||
<br /> | |||
== MRS (magnetic resonance spectroscopy) == | |||
* [[Creatinine]] levels may be decreased. | |||
* [[Choline]]-containing compumds may be incresed, however, in cases of necrosis in highly malignant tumors they may be decreased. | |||
* [[Lactate]] levels may be increased. | |||
* N-acetyl aspartate can be significantly decreased. | |||
* MRS can help with classification of tumors as ratios of these compunds can help with classification of these malignacies. | |||
==Ultrasound== | ==Ultrasound== | ||
There are no ultrasound findings associated with oligoastrocytoma. | There are no specific ultrasound findings associated with oligoastrocytoma. | ||
==Other Imaging Findings== | ==Other Imaging Findings== | ||
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
Other diagnostic studies for oligoastrocytoma include [[biopsy]] ("''star-shaped''" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance) and [[fish|fluorescent in-situ hybridization (FISH) technique]] (deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]).<ref name=diagOAwiki>Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015</ref><ref name=turk>{{Citation | Other diagnostic studies for oligoastrocytoma include [[biopsy]] ("''star-shaped''" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance) and [[fish|fluorescent in-situ hybridization (FISH) technique]] (deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]).<ref name="diagOAwiki">Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015</ref><ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=20 October, 2015 }}</ref> | ||
==Treatment== | ==Treatment== | ||
==Medical Therapy== | ==Medical Therapy== | ||
The predominant therapy for oligoastrocytoma is surgical resection.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> Adjunctive chemotherapy and radiation are required.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name=rxcanada>Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015</ref><ref name=rxchemo>Chemotherapeutic drugs in malignant gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/treatment/chemotherapy/?region=on. Accessed on October 20, 2015</ref><ref name="pmid15284265">{{cite journal| author=Hoang-Xuan K, Capelle L, Kujas M, Taillibert S, Duffau H, Lejeune J et al.| title=Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. | journal=J Clin Oncol | year= 2004 | volume= 22 | issue= 15 | pages= 3133-8 | pmid=15284265 | doi=10.1200/JCO.2004.10.169 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284265 }} </ref><ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref><ref name="pmid20555079">{{cite journal| author=Stupp R, Tonn JC, Brada M, Pentheroudakis G, ESMO Guidelines Working Group| title=High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. | journal=Ann Oncol | year= 2010 | volume= 21 Suppl 5 | issue= | pages= v190-3 | pmid=20555079 | doi=10.1093/annonc/mdq187 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20555079 }} </ref> Supportive therapy for oligoastrocytoma includes [[anticonvulsants]] and [[corticosteroids]].<ref name=rxcanada>Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015</ref> | |||
* The predominant therapy for oligoastrocytoma is surgical resection.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref> | |||
* Adjunctive chemotherapy and radiation are required.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="rxcanada">Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015</ref><ref name="rxchemo">Chemotherapeutic drugs in malignant gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/treatment/chemotherapy/?region=on. Accessed on October 20, 2015</ref><ref name="pmid15284265">{{cite journal| author=Hoang-Xuan K, Capelle L, Kujas M, Taillibert S, Duffau H, Lejeune J et al.| title=Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. | journal=J Clin Oncol | year= 2004 | volume= 22 | issue= 15 | pages= 3133-8 | pmid=15284265 | doi=10.1200/JCO.2004.10.169 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284265 }} </ref><ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref><ref name="pmid20555079">{{cite journal| author=Stupp R, Tonn JC, Brada M, Pentheroudakis G, ESMO Guidelines Working Group| title=High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. | journal=Ann Oncol | year= 2010 | volume= 21 Suppl 5 | issue= | pages= v190-3 | pmid=20555079 | doi=10.1093/annonc/mdq187 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20555079 }} </ref> | |||
* Supportive therapy for oligoastrocytoma includes [[anticonvulsants]] and [[corticosteroids]].<ref name="rxcanada">Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015</ref> | |||
* Temozolomide can be effective for cases of recurrent anaplastic oligoastrocytoma. | |||
==Surgery== | ==Surgery== | ||
[[Surgery]] is the first-line treatment option for patients with oligoastrocytoma.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name=rxcanada>Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015</ref><ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref> [[Hydrocephalus surgery|CSF shunting]] is usually reserved for patients with [[hydrocephalus]].<ref name="pmid16048288">{{cite journal| author=Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F et al.| title=Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas. | journal=Neurosurg Focus | year= 2005 | volume= 18 | issue= 6A | pages= E2 | pmid=16048288 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16048288 }} </ref> | [[Surgery]] is the first-line treatment option for patients with oligoastrocytoma.<ref name="pmid20425038">{{cite journal| author=Pouratian N, Schiff D| title=Management of low-grade glioma. | journal=Curr Neurol Neurosci Rep | year= 2010 | volume= 10 | issue= 3 | pages= 224-31 | pmid=20425038 | doi=10.1007/s11910-010-0105-7 | pmc=PMC2857752 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425038 }} </ref><ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="rxcanada">Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015</ref><ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref> [[Hydrocephalus surgery|CSF shunting]] is usually reserved for patients with [[hydrocephalus]].<ref name="pmid16048288">{{cite journal| author=Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F et al.| title=Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas. | journal=Neurosurg Focus | year= 2005 | volume= 18 | issue= 6A | pages= E2 | pmid=16048288 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16048288 }} </ref> | ||
==Primary Prevention== | ==Primary Prevention== | ||
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Latest revision as of 12:25, 30 September 2019
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Oligoastrocytoma Microchapters |
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Diagnosis |
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Treatment |
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Oligoastrocytoma overview On the Web |
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American Roentgen Ray Society Images of Oligoastrocytoma overview |
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Risk calculators and risk factors for Oligoastrocytoma overview |
- Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Oligoastrocytomas are extremely rare brain tumors that together with oligodendrogliomas account for approximately 10% of primary CNS tumors. They are a subtype of gliomas and account for 25% of all gliomas. These tumors are composed of astrocytoma and oligodendroglioma. Celli et al in 1994 gave the name of "oligoastrocytoma" to those oligodendroglial tumors where the astrocytes formed more than 20% of the tumor cells. Morphologic characteristics of oligoastrocytomas resemble those of pure oligodendrogliomas and astrocytomas. Oligoastrocytomas are primarily tumors of adulthood with peak incidence in 4th to 6th decade of life. Even though these tumors can arise anywhere within the the brain, but usually in the supratentorial region, especially frontal and temporal lobes are the most common sites. Based on WHO classification, oligoastrocytomas are devided into two classes: oligoastrocytoma corresponding to grade II and anaplastic oligoastrocytoma corresponding to grade III. Clinical manifestaions of oligoastrocytoma vary and can range from seizure and headaches to personality changes. Many risk fators seem to play a role in pathogenesis of oligoastrocytoma. The molecular changes can resemble those of oligodendrogliomas (loss of heterozygosity on 1p and 19q, in 30-70% of cases) or astrocytoma (TP53 mutation and loss of heterozygosity on 17p). Treatment is based on sugery, however the tumor is responsive to chemotherapy in most cases, when necessary.
Historical Perspective
The broad topic "oligodendroglial tumors", of which oligoastrocytoma is a part of, was first described by Bailey and Cushing in 1926. They reported that gliomas were formed by transformation of glial cells.Celli et al in 1994 gave the name of "oligoastrocytoma" to those oligodendroglial tumors where the astrocytes formed more than 20% of the tumor cells.
Classification
Oligoastrocytoma may be classified according to the WHO classification of the central nervous system tumors into two subtypes: oligoastrocytoma (OAII) and anaplastic oligoastrocytoma (OAIII). OAII can evolve to OAIII overtime.
Pathophysiology
Oligoastrocytomas are mixed tumors that arise from the proliferation of both oligodendrocytes and astrocytes. Genes associated with the pathogenesis of oligoastrocytoma and anaplastic oligoastrocytoma include IDH1, p53, EGFR, ATRX, EGFR, PTEN, MGMT, CIC, and FUBP1. 30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of 1p and 19q.
Causes
Common causes of oligoastrocytoma include genetic mutations and ionizing radiation. Common genetic mutations involved in the development of oligoastrocytoma can be found here. Genes associated with the pathogenesis of oligoastrocytoma and anaplastic oligoastrocytoma include IDH1, p53, EGFR, ATRX, EGFR, PTEN, MGMT, CIC, and FUBP1.
Differentiating Oligodendroglioma from other diseases
As clinical manifestation of oligoastrocytoma differ based on the site of the tumor, many disease and intracranial space occupying lesions can be named as its differential diagnosis: Astrocytoma, anaplastic astrocytoma, oligodendroglioma, pilocytic astrocytoma, central neurocytoma, ependymoma, dysembryoplastic neuroepithelial tumor, meningioma, cerebral metastasis, multiple sclerosis, and intracranial cysts.
Epidemiology and Demographics
Oligoastrocytoma is the third most common glioma. Oligoastrocytoma accounts for 1% of all brain tumors and 5–10% of all glial neoplasms. The incidence of oligoastrocytoma is approximately 0.03 per 100,000 individuals in the United States. Oligoastrocytoma is a disease that tends to affect the young and middle-aged adult population with peak incidence in 4th to 6th decades of life. The median age of diagnosis is 42 years. Males are more commonly affected with oligoastrocytoma than females. Oligoastrocytoma usually affects individuals of the Caucasian race. The incidence rate of oligoastrocytoma is higher in developed countries than in developing countries.
Risk factors
Common risk factors in the development of oligoastrocytoma include family history of brain tumors, ionizing radiation, and allergic diseases. However other risk factors such as viral infections and immune factors seem to play a role. Of these factors, only the association of ionizing radiation has been proven.
Screening
There is insufficient evidence to recommend routine screening for oligoastrocytoma.
Natural History, Complications and Prognosis
- If left untreated, patients with oligoastrocytoma may progress to develop seizures, focal neurological deficits, hydrocephalus, brain herniation, intracranial hemorrhage, and ultimately death.[1][2][3]
- Oligoastrocytomas are slow growing tumors.[4]
- These tumors can evolve in terms of WHO classification from OAII to OAIII over time.
- Common complications associated with oligoastrocytoma include hydrocephalus, intracranial hemorrhage, coma, metastasis, venous thromboembolism, and side effects of chemotherapy and radiation.[2][5][6][1][7][3]
- Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligoastrocytoma may vary. However, the prognosis is generally regarded as good.[8]
- The prognosis of low-grade oligoastrocytoma is more favorable than that for anaplastic oligoastrocytoma because of the more indolent course and younger age at which most patients are diagnosed.[2]
- The prognosis of oligoastrocytoma is better than that of astrocytoma and poorer than that of oligodendrogliomas.
- The 1, 5, and 10-year survival rates of patients with oligoastrocytoma are approximately 87%, 56.97%, and 45.80%, respectively.[9]
Diagnosis
- Histopathologic examination remains the gold standard for diagnosis of oligoastrocytoma.
- On gross pathology, oligoastrocytoma is characterized by a soft, well-defined, grey-tan, mucoid or hemorrhagic, calcified mass with or without necrosis, which may expand the gyrus and cause blurring of the grey-white junction.[4]
- In histopathologic examination:
- Oligoastrocytoma is characterized by highly cellular lesions composed of both oligodendroglial and astrocytic components.[10][11][12][13][14]
- In addition to the histological features of oligoastrocytoma, anaplastic oligoastrocytoma also has significant or brisk mitotic activity, marked cytologic and nuclear atypia, necrosis, apoptosis, and microvacular proliferation.[10][11][12]
- Oligoastrocytoma is demonstrated by positivity to tumor markers such as MAP2, GFAP(due to presence of reactive astrocytes), IDH1, OLIG-1 protein, OLIG-2 protein, and Iba-2 protein.[15][16][8][2][4]
Staging
There is no established system for the staging of oligoastrocytoma.[1]
History and Symptoms
When evaluating a patient for oligoastrocytoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough past medical history review. Other specific areas of focus when obtaining the history include review of the history of any ionizing radiation, allergic diseases, and the family history for any brain tumors.[17][18][1] Symptoms associated with oligoastrocytoma include seizure, headache, nausea, vomiting, loss of balance, vision loss, and changes in speech, mood, and personality.[19][11][20][21][6][22][1]
Physical examination
Common physical examination findings of oligoastrocytoma include:
- nystagmus
- papilledema
- esotropia
- visual field loss
- altered mental status
- focal neurological deficits.[21][1]
Laboratory Findings
Some patients with oligoastrocytoma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus.[23][24]
Chest X Ray
Chest x-ray may be performed to detect metastases of anaplastic oligoastrocytoma to the lungs.[25][7]
CT
- Head CT scan may be helpful in the diagnosis of oligoastrocytoma, however it lacks the required specificity for definitive diagnosis.
- The findings on CT scan have unsharp edges and appear as patchy lesions.
- Tumors may show areas of calcification in CT scan.
- Findings on CT scan suggestive of oligoastrocytoma are intra-axial low-attenuation areas with mass effect and little to no associated edema.[26]
MRI
- Brain MRI is helpful in the diagnosis of oligoastrocytoma.
- On brain MRI, oligoastrocytoma is characterized by a mass which is typically hypointense on T1-weighted images and hyperintense on T2-weighted images.
- No enhancement is observed on gadolinium enhanced T1-weighted images.[27]
MRS (magnetic resonance spectroscopy)
- Creatinine levels may be decreased.
- Choline-containing compumds may be incresed, however, in cases of necrosis in highly malignant tumors they may be decreased.
- Lactate levels may be increased.
- N-acetyl aspartate can be significantly decreased.
- MRS can help with classification of tumors as ratios of these compunds can help with classification of these malignacies.
Ultrasound
There are no specific ultrasound findings associated with oligoastrocytoma.
Other Imaging Findings
Other imaging studies for oligoastrocytoma include PET scan (accumulation of [18F]-fluorodeoxyglucose) and bone scan (bone metastasis).[28][29][30][7]
Other Diagnostic Studies
Other diagnostic studies for oligoastrocytoma include biopsy ("star-shaped" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).[31][32]
Treatment
Medical Therapy
- The predominant therapy for oligoastrocytoma is surgical resection.[21][1]
- Adjunctive chemotherapy and radiation are required.[21][1][33][34][35][36][5]
- Supportive therapy for oligoastrocytoma includes anticonvulsants and corticosteroids.[33]
- Temozolomide can be effective for cases of recurrent anaplastic oligoastrocytoma.
Surgery
Surgery is the first-line treatment option for patients with oligoastrocytoma.[21][1][33][37] CSF shunting is usually reserved for patients with hydrocephalus.[24]
Primary Prevention
There are no primary preventive measures available for oligoastrocytoma.
Secondary Prevention
Patients treated for oligoastrocytoma should follow-up for secondary prevention. Secondary prevention strategies following oligoastrocytoma include a clinical assessment of neurological function and corticosteroid usage, checking for signs of venous thromboembolism, regular laboratory tests, and routine imaging (MRI and Positron Emission Tomography) at scheduled intervals after treatment.[5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Chandana SR, Movva S, Arora M, Singh T (2008). "Primary brain tumors in adults". Am Fam Physician. 77 (10): 1423–30. PMID 18533376.
- ↑ 2.0 2.1 2.2 2.3 Grier, J. T. (2006). "Low-Grade Gliomas in Adults". The Oncologist. 11 (6): 681–693. doi:10.1634/theoncologist.11-6-681. ISSN 1083-7159.
- ↑ 3.0 3.1 Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC; et al. (1986). "Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report". Neurosurgery. 19 (2): 278–81. PMID 3748360.
- ↑ 4.0 4.1 4.2 Adesina, Adekunle (2010). Atlas of pediatric brain tumors. New York: Springer. ISBN 9781441910622.
- ↑ 5.0 5.1 5.2 Stupp R, Tonn JC, Brada M, Pentheroudakis G, ESMO Guidelines Working Group (2010). "High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up". Ann Oncol. 21 Suppl 5: v190–3. doi:10.1093/annonc/mdq187. PMID 20555079.
- ↑ 6.0 6.1 Signs and symptoms of glioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Glioma. Accessed on October 20, 2015
- ↑ 7.0 7.1 7.2 Finsterer J, Breiteneder S, Mueller MR, Wogritsch C, Vesely M, Kleinert R; et al. (1998). "Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III". Oncology. 55 (4): 345–8. PMID 9663425.
- ↑ 8.0 8.1 Liang Y, Bollen AW, Nicholas MK, Gupta N (2005). "Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas". BMC Clin Pathol. 5: 6. doi:10.1186/1472-6890-5-6. PMC 1182359. PMID 16018821.
- ↑ One–, Two–, Three–, Four–, Five–, and 10–year relative survival rates for selected malignant brain and central nervous system tumors, Seer 17 Registries, 1995-2006. CBTRUS 2015. http://www.cbtrus.org/2010-NPCR-SEER/CBTRUS-WEBREPORT-Final-3-2-10.pdf. Accessed on October 16, 2015
- ↑ 10.0 10.1 Pathology of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 16, 2015
- ↑ 11.0 11.1 11.2 Naugle DK, Duncan TD, Grice GP (2004). "Oligoastrocytoma". Radiographics. 24 (2): 598–600. doi:10.1148/rg.242035069. PMID 15026604.
- ↑ 12.0 12.1 Pathology of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 16, 2015
- ↑ Love, S.; Loius, D. & Ellison, D.W. (2008), Greenfield's neuropathology, 1 (8th ed.), Boca Raton, Florida: Hodder Arnold
- ↑ Histology of anaplastic oligoastrocytes. Dr. Frank Gaillard. Radiopaedia 2015. http://radiopaedia.org/cases/anaplastic-oligoastrocytoma. Accessed on October 19, 2015
- ↑ IHC of oligoastrocytoma. Librepathology 2015. http://librepathology.org/wiki/index.php/Oligoastrocytoma. Accessed on October 16, 2015
- ↑ Kolenda-Roberts HM, Harris N, Singletary E, Hardisty JF (2013). "Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat". Toxicol Pathol. 41 (1): 98–108. doi:10.1177/0192623312452492. PMID 22821367.
- ↑ McCarthy BJ, Rankin KM, Aldape K, Bondy ML, Brännström T, Broholm H; et al. (2011). "Risk factors for oligodendroglial tumors: a pooled international study". Neuro Oncol. 13 (2): 242–50. doi:10.1093/neuonc/noq173. PMC 3064625. PMID 21149253.
- ↑ Terry MB, Howe G, Pogoda JM, Zhang FF, Ahlbom A, Choi W; et al. (2009). "An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group". Ann Epidemiol. 19 (3): 161–71. doi:10.1016/j.annepidem.2008.12.010. PMC 3832293. PMID 19216998.
- ↑ Symptoms of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 16, 2015
- ↑ Symptoms of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015
- ↑ 21.0 21.1 21.2 21.3 21.4 Pouratian N, Schiff D (2010). "Management of low-grade glioma". Curr Neurol Neurosci Rep. 10 (3): 224–31. doi:10.1007/s11910-010-0105-7. PMC 2857752. PMID 20425038.
- ↑ Symptoms of oligoastrocytoma. American Brain Tumor Association 2015. http://www.abta.org/secure/oligodendrioma-oligo.pdf. Accessed on October 21, 2015
- ↑ Stark AM, Hugo HH, Mehdorn HM, Knerlich-Lukoschus F (2009). "Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma". Case Rep Med. 2009: 370901. doi:10.1155/2009/370901. PMC 2797365. PMID 20052406.
- ↑ 24.0 24.1 Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F; et al. (2005). "Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas". Neurosurg Focus. 18 (6A): E2. PMID 16048288.
- ↑ Lone, N. A.; Thameem, D.; Syed, S. J.; Kingree, R. M.; Holly, J. S.; Dhand, R.; Jadhav, A. (2010). "Pulmonary Deposits of Anaplastic Oligoastrocytoma: Can It Be Prevented or Early Detected?". Chest. 138 (4 MeetingAbstracts): 64A–64A. doi:10.1378/chest.10865. ISSN 0012-3692.
- ↑ Radiologic features of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 18, 2015
- ↑ Radiologic MRI features of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma
- ↑ la Fougere, C.; Suchorska, B.; Bartenstein, P.; Kreth, F.-W.; Tonn, J.-C. (2011). "Molecular imaging of gliomas with PET: Opportunities and limitations". Neuro-Oncology. 13 (8): 806–819. doi:10.1093/neuonc/nor054. ISSN 1522-8517.
- ↑ Beauchesne P (2011). "Extra-neural metastases of malignant gliomas: myth or reality?". Cancers (Basel). 3 (1): 461–77. doi:10.3390/cancers3010461. PMC 3756372. PMID 24212625.
- ↑ Al-Ali F, Hendon AJ, Liepman MK, Wisniewski JL, Krinock MJ, Beckman K (2005). "Oligodendroglioma metastatic to bone marrow". AJNR Am J Neuroradiol. 26 (9): 2410–4. PMID 16219856.
- ↑ Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015
- ↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 20 October, 2015 Check date values in:
|accessdate=(help) - ↑ 33.0 33.1 33.2 Treatment of mixed gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on. Accessed on October 20, 2015
- ↑ Chemotherapeutic drugs in malignant gliomas. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/treatment/chemotherapy/?region=on. Accessed on October 20, 2015
- ↑ Hoang-Xuan K, Capelle L, Kujas M, Taillibert S, Duffau H, Lejeune J; et al. (2004). "Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions". J Clin Oncol. 22 (15): 3133–8. doi:10.1200/JCO.2004.10.169. PMID 15284265.
- ↑ Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.