|
|
| (56 intermediate revisions by 2 users not shown) |
| Line 4: |
Line 4: |
| {{CMG}}; {{AE}} {{S.M.}} | | {{CMG}}; {{AE}} {{S.M.}} |
|
| |
|
| {{SK}} Waldenstrom's macroglobulinemia; Waldenstrom's disease; Primary macroglobulinemia; Hyperviscosity syndrome; Lymphoplasmacytoid lymphoma | | {{SK}} Plasmacytoid lymphocytic [[lymphoma]]; Familial Waldenström's macroglobulinemia; Primary macroglobulinemia; Hyperviscosity syndrome; Lymphoplasmacytoid [[lymphoma]] |
|
| |
|
| ==Overview== | | ==[[Lymphoplasmacytic lymphoma overview|Overview]]== |
|
| |
|
| ==Differentiating Lymphoplasmacytic Lymphoma from Other B cell lymphoid neoplasms== | | ==[[Lymphoplasmacytic lymphoma historical perspective|Historical Perspective]]== |
| Waldenström macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:
| |
|
| |
|
| *[[Chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]]:
| | ==[[Lymphoplasmacytic lymphoma classification|Classification]]== |
| :*Always express CD5
| |
| :*Usually CD23 positive<ref name="CLL">{{cite journal |vauthors=Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ |title=Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines |journal=Blood |volume=111 |issue=12 |pages=5446–56 |year=2008 |pmid=18216293 |pmc=2972576 |doi=10.1182/blood-2007-06-093906 |url=}}</ref>
| |
|
| |
|
| *[[B-cell prolymphocytic leukemia]]:
| | ==[[Lymphoplasmacytic lymphoma pathophysiology|Pathophysiology]]== |
| :*Express bright surface [[Immunoglobulin M|IgM]], [[CD20]] and other B-cell antigens ([[CD19]], [[CD22]], [[CD79a]], [[FMC7]])<ref name=",m">{{cite journal |vauthors=Del Giudice I, Davis Z, Matutes E, Osuji N, Parry-Jones N, Morilla A, Brito-Babapulle V, Oscier D, Catovsky D |title=IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL) |journal=Leukemia |volume=20 |issue=7 |pages=1231–7 |year=2006 |pmid=16642047 |doi=10.1038/sj.leu.2404238 |url=}}</ref><ref name="njl">{{cite journal |vauthors=Ravandi F, O'Brien S |title=Chronic lymphoid leukemias other than chronic lymphocytic leukemia: diagnosis and treatment |journal=Mayo Clin. Proc. |volume=80 |issue=12 |pages=1660–74 |year=2005 |pmid=16342661 |doi=10.4065/80.12.1660 |url=}}</ref>
| |
|
| |
|
| *[[Follicular lymphoma]]:
| | ==[[Lymphoplasmacytic lymphoma causes|Causes]]== |
| :*Express [[CD10]], [[HLA-DR]], pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, [[Immunoglobulin G|IgG]], or [[IgA]]
| |
| :*Rearrangement of Bcl-2<ref name="FL">{{cite journal |vauthors=Karube K, Guo Y, Suzumiya J, Sugita Y, Nomura Y, Yamamoto K, Shimizu K, Yoshida S, Komatani H, Takeshita M, Kikuchi M, Nakamura N, Takasu O, Arakawa F, Tagawa H, Seto M, Ohshima K |title=CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features |journal=Blood |volume=109 |issue=7 |pages=3076–9 |year=2007 |pmid=17138820 |doi=10.1182/blood-2006-09-045989 |url=}}</ref><ref name="FL1">{{cite journal |vauthors=Anderson KC, Bates MP, Slaughenhoupt BL, Pinkus GS, Schlossman SF, Nadler LM |title=Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation |journal=Blood |volume=63 |issue=6 |pages=1424–33 |year=1984 |pmid=6609729 |doi= |url=}}
| |
| :*Bone marrow infiltration of small, cleaved cells that are usually paratrabecular
| |
| </ref>
| |
|
| |
|
| *[[Multiple myeloma]]:
| | ==[[Lymphoplasmacytic lymphoma differential diagnosis|Differentiating Lymphoplasmacytic lymphoma from other Diseases]]== |
| :*Express CD138, CD38, CD79a, VS38c and CD56 (70%)
| |
| :*Presence of plasmacytic cell infiltration of bone marrow, osteolytic lesions, and [[renal insufficiency]]
| |
| :*Translocation involving chromosome 11 (t11;14)<ref name="UTD">{{cite journal |vauthors=Pangalis GA, Kyrtsonis MC, Kontopidou FN, Vassilakopoulos TP, Siakantaris MP, Dimopoulou MN, Kittas C, Angelopoulou MK |title=Differential diagnosis of Waldenstrom's macroglobulinemia from other low-grade B-cell lymphoproliferative disorders |journal=Semin. Oncol. |volume=30 |issue=2 |pages=201–5 |year=2003 |pmid=12720136 |doi=10.1053/sonc.2003.50046 |url=}}</ref>
| |
|
| |
|
| *[[Mantle cell lymphoma]]:
| | ==[[Lymphoplasmacytic lymphoma epidemiology and demographics|Epidemiology and Demographics]]== |
| :* Expresses CD5+ and CD23+
| |
| :* Expresses surface IgM, IgD, and cyclin D1 in majority of cases
| |
| :*Infiltration of bone marrow by monomorphous small lymphoid cells with irregular nuclei<ref name="MCL">{{cite journal |vauthors=Dorfman DM, Pinkus GS |title=Distinction between small lymphocytic and mantle cell lymphoma by immunoreactivity for CD23 |journal=Mod. Pathol. |volume=7 |issue=3 |pages=326–31 |year=1994 |pmid=8058704 |doi= |url=}}</ref><ref name="MCL1">{{cite journal |vauthors=DiRaimondo F, Albitar M, Huh Y, O'Brien S, Montillo M, Tedeschi A, Kantarjian H, Lerner S, Giustolisi R, Keating M |title=The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease |journal=Cancer |volume=94 |issue=6 |pages=1721–30 |year=2002 |pmid=11920534 |doi= |url=}}</ref>
| |
|
| |
|
| *[[Marginal zone lymphoma]]:
| | ==[[Lymphoplasmacytic lymphoma risk factors|Risk Factors]]== |
| :*Expresses B cell markers CD19, CD20, and CD22
| |
| :*Infiltrates the bone marrow with a characteristic intertrabecular and intrasinusoidal pattern
| |
| :*Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% )<ref name="add">{{cite journal |vauthors=Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD |title=World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997 |journal=J. Clin. Oncol. |volume=17 |issue=12 |pages=3835–49 |year=1999 |pmid=10577857 |doi= |url=}}</ref><ref name="asdf">{{cite journal |vauthors=Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC |title=A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group |journal=Blood |volume=84 |issue=5 |pages=1361–92 |year=1994 |pmid=8068936 |doi= |url=}}</ref>
| |
|
| |
|
| ==Epidemiology and Demographics== | | ==[[Lymphoplasmacytic lymphoma screening|Screening]]== |
|
| |
|
| ==Risk Factors== | | ==[[Lymphoplasmacytic lymphoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
| | |
| ==Screening==
| |
| | |
| ==Natural History, Complications, and Prognosis==
| |
|
| |
|
| ==Diagnosis== | | ==Diagnosis== |
| *Not all the diagnostic tests mentioned are performed in a WM patient. A doctor takes into account the following factors before choosing diagnostic tests in a particular patient:
| |
| **Suspected type of cancer.
| |
| **Signs and symptoms.
| |
| **Age.
| |
| **Medical condition of the patient.
| |
| **Results of earlier medical tests.
| |
| ===History and Symptoms===
| |
| === Manifestations of WM ===
| |
| Following is a list of WM manifestations with attributable causes:<ref name="pmid15735132">{{cite journal| author=Dimopoulos MA, Kyle RA, Anagnostopoulos A, Treon SP| title=Diagnosis and management of Waldenstrom's macroglobulinemia. | journal=J Clin Oncol | year= 2005 | volume= 23 | issue= 7 | pages= 1564-77 | pmid=15735132 | doi=10.1200/JCO.2005.03.144 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15735132 }} </ref><ref name="DimopoulosPanayiotidis2000">{{cite journal|last1=Dimopoulos|first1=Meletios A.|last2=Panayiotidis|first2=Panayiotis|last3=Moulopoulos|first3=Lia A.|last4=Sfikakis|first4=Petros|last5=Dalakas|first5=Marinos|title=Waldenström’s Macroglobulinemia: Clinical Features, Complications, and Management|journal=Journal of Clinical Oncology|volume=18|issue=1|year=2000|pages=214–214|issn=0732-183X|doi=10.1200/JCO.2000.18.1.214}}</ref><ref name="pmid3110508">{{cite journal| author=Kyle RA, Garton JP| title=The spectrum of IgM monoclonal gammopathy in 430 cases. | journal=Mayo Clin Proc | year= 1987 | volume= 62 | issue= 8 | pages= 719-31 | pmid=3110508 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3110508 }} </ref><ref name="pmid12883242">{{cite journal| author=Lin P, Bueso-Ramos C, Wilson CS, Mansoor A, Medeiros LJ| title=Waldenstrom macroglobulinemia involving extramedullary sites: morphologic and immunophenotypic findings in 44 patients. | journal=Am J Surg Pathol | year= 2003 | volume= 27 | issue= 8 | pages= 1104-13 | pmid=12883242 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12883242 }} </ref><ref name="pmid8123836">{{cite journal| author=Dimopoulos MA, Alexanian R| title=Waldenstrom's macroglobulinemia. | journal=Blood | year= 1994 | volume= 83 | issue= 6 | pages= 1452-9 | pmid=8123836 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8123836 }} </ref><ref name="pmid6767276">{{cite journal| author=Fudenberg HH, Virella G| title=Multiple myeloma and Waldenström macroglobulinemia: unusual presentations. | journal=Semin Hematol | year= 1980 | volume= 17 | issue= 1 | pages= 63-79 | pmid=6767276 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6767276 }} </ref><ref name="pmid9671845">{{cite journal| author=Fadil A, Taylor DE| title=The lung and Waldenström's macroglobulinemia. | journal=South Med J | year= 1998 | volume= 91 | issue= 7 | pages= 681-5 | pmid=9671845 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9671845 }} </ref><ref name="pmid9198063">{{cite journal| author=Veltman GA, van Veen S, Kluin-Nelemans JC, Bruijn JA, van Es LA| title=Renal disease in Waldenström's macroglobulinaemia. | journal=Nephrol Dial Transplant | year= 1997 | volume= 12 | issue= 6 | pages= 1256-9 | pmid=9198063 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9198063 }} </ref><ref name="pmid10188670">{{cite journal| author=Daoud MS, Lust JA, Kyle RA, Pittelkow MR| title=Monoclonal gammopathies and associated skin disorders. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 4 | pages= 507-35; quiz 536-8 | pmid=10188670 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10188670 }} </ref><ref name="pmid6801795">{{cite journal| author=Orellana J, Friedman AH| title=Ocular manifestations of multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathy. | journal=Surv Ophthalmol | year= 1981 | volume= 26 | issue= 3 | pages= 157-69 | pmid=6801795 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6801795 }} </ref><ref name="pmid9686227">{{cite journal| author=Civit T, Coulbois S, Baylac F, Taillandier L, Auque J| title=[Waldenström's macroglobulinemia and cerebral lymphoplasmocytic proliferation: Bing and Neel syndrome. Apropos of a new case]. | journal=Neurochirurgie | year= 1997 | volume= 43 | issue= 4 | pages= 245-9 | pmid=9686227 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9686227 }} </ref><ref name="pmid10357087">{{cite journal| author=Kwaan HC, Bongu A| title=The hyperviscosity syndromes. | journal=Semin Thromb Hemost | year= 1999 | volume= 25 | issue= 2 | pages= 199-208 | pmid=10357087 | doi=10.1055/s-2007-994921 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10357087 }} </ref><ref name="pmid3094151">{{cite journal| author=Farhangi M, Merlini G| title=The clinical implications of monoclonal immunoglobulins. | journal=Semin Oncol | year= 1986 | volume= 13 | issue= 3 | pages= 366-79 | pmid=3094151 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3094151 }} </ref><ref name="pmid2104668">{{cite journal| author=| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-1990. A 66-year-old woman with Waldenström's macroglobulinemia, diarrhea, anemia, and persistent gastrointestinal bleeding. | journal=N Engl J Med | year= 1990 | volume= 322 | issue= 3 | pages= 183-92 | pmid=2104668 | doi=10.1056/NEJM199001183220308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2104668 }} </ref><ref name="GertzKyle1993">{{cite journal|last1=Gertz|first1=M A|last2=Kyle|first2=R A|last3=Noel|first3=P|title=Primary systemic amyloidosis: a rare complication of immunoglobulin M monoclonal gammopathies and Waldenström's macroglobulinemia.|journal=Journal of Clinical Oncology|volume=11|issue=5|year=1993|pages=914–920|issn=0732-183X|doi=10.1200/JCO.1993.11.5.914}}</ref><ref name="pmid12720162">{{cite journal| author=Gertz MA, Kyle RA| title=Amyloidosis with IgM monoclonal gammopathies. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 325-8 | pmid=12720162 | doi=10.1053/sonc.2003.50060 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720162 }} </ref><ref name="pmid11530809">{{cite journal| author=Gardyn J, Schwartz A, Gal R, Lewinski U, Kristt D, Cohen AM| title=Waldenström's macroglobulinemia associated with AA amyloidosis. | journal=Int J Hematol | year= 2001 | volume= 74 | issue= 1 | pages= 76-8 | pmid=11530809 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11530809 }} </ref><ref name="pmid9603799">{{cite journal| author=Ropper AH, Gorson KC| title=Neuropathies associated with paraproteinemia. | journal=N Engl J Med | year= 1998 | volume= 338 | issue= 22 | pages= 1601-7 | pmid=9603799 | doi=10.1056/NEJM199805283382207 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9603799 }} </ref><ref name="pmid11556684">{{cite journal| author=Vital A| title=Paraproteinemic neuropathies. | journal=Brain Pathol | year= 2001 | volume= 11 | issue= 4 | pages= 399-407 | pmid=11556684 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11556684 }} </ref><ref name="pmid6807086">{{cite journal| author=Crisp D, Pruzanski W| title=B-cell neoplasms with homogeneous cold-reacting antibodies (cold agglutinins). | journal=Am J Med | year= 1982 | volume= 72 | issue= 6 | pages= 915-22 | pmid=6807086 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6807086 }} </ref><ref name="pmid6777101">{{cite journal| author=Lindström FD, Hed J, Eneström S| title=Renal pathology of Waldenström's macroglobulinaemia with monoclonal antiglomerular antibodies and nephrotic syndrome. | journal=Clin Exp Immunol | year= 1980 | volume= 41 | issue= 2 | pages= 196-204 | pmid=6777101 | doi= | pmc=1537007 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6777101 }} </ref><ref name="pmid15019332">{{cite journal| author=Sen HN, Chan CC, Caruso RC, Fariss RN, Nussenblatt RB, Buggage RR| title=Waldenström's macroglobulinemia-associated retinopathy. | journal=Ophthalmology | year= 2004 | volume= 111 | issue= 3 | pages= 535-9 | pmid=15019332 | doi=10.1016/j.ophtha.2003.05.036 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15019332 }} </ref>
| |
|
| |
| {| class="wikitable"
| |
| |+ '''Manifestations of WM'''
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Cause
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Manifestations
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |Tumor infiltration
| |
| | style="background:#F5F5F5;" align="center" + |Cytopenia, fever, night sweats, weight loss, lymphadenopathy, hepatomegaly, spleenomegaly, pulmonary infiltrates, nodules or masses, pleural effusion, abdominal pain, swelling and blood in stools secondary to stomach and bowel infiltration, renal and perirenal masses, maculopapular lesions, plaques or nodules secondary to dermis infiltration, lesions involving retro-orbital lymphoid tissue and lacrimal glands, infiltration of the conjunctiva and malignant vitreitis, Bing-Neel syndrome consists of confusion, memory loss, disorientation, motor dysfunction, and eventually coma.
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |Circulating monoclonal IgM
| |
| | style="background:#F5F5F5;" align="center" + |Hyperviscosity syndrome, Type 1 Cryoglobulinemia (consists of Raynaud's phenomenon, skin ulcers & necrosis and cold urticaria), frequent bruising, prolonged bleeding and clotting times.
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |IgM deposition into tissues
| |
| | style="background:#F5F5F5;" align="center" + |Sub-endothelial deposits in glomerular loops leading to non-selective proteinuria, dehydration, and uremia, Firm, flesh-colored skin papules and nodules have been reported and are called macroglobulinemia cutis, Diarrhea, malabsorption, or gastrointestinal bleeding.
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |Amyloidogenic properties of IgM
| |
| | style="background:#F5F5F5;" align="center" + |Organs more commonly affected by amyloidosis were the heart (44%), the peripheral nerves (38%), the kidneys (32%), the soft tissues (18%), the liver (14%), and lungs (10%), nephrotic syndrome and gastrointestinal involvement.
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |Autoantibody activity of IgM
| |
| | style="background:#F5F5F5;" align="center" + |Distal, symmetric, chronic demyelinating peripheral neuropathy, Type 2 cryoglobulinemia characterized by vasculitis affecting small vessels of skin, kidneys, liver, and peripheral nerves, Extravascular chronic hemolytic anemia called cold agglutinin disease exacerbated by cold exposure, glomerulonephritis, paraneoplastic pemphigus, and retinitis/retinopathy.
| |
| |}
| |
| ==== Common Symptoms ====
| |
| Common symptoms of Waldenström macroglobulinemia include:<ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref><ref name="pmid12720138">{{cite journal| author=Merlini G, Baldini L, Broglia C, Comelli M, Goldaniga M, Palladini G et al.| title=Prognostic factors in symptomatic Waldenstrom's macroglobulinemia. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 211-5 | pmid=12720138 | doi=10.1053/sonc.2003.50064 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720138 }} </ref>
| |
| * [[B symptoms|Constitutional B symptoms]] as seen in other types of NHL:
| |
| **[[Weakness]] (due to normocytic anemia associated with IgM binding to RBCs).
| |
| **[[Anorexia]].
| |
| **Unexplained [[weight loss]].
| |
| **Unexplained [[fever]].
| |
| **Heavy sweating, especially at night causing drenching of one's cloths and bedsheet.
| |
| **Severe/extensive skin itchiness.
| |
| *Fatigue.
| |
| *Sensorimotor [[peripheral neuropathy]] (mostly associated with numbness and tingling, i.e. painful pins and needle sensation, of the fingers or toes).
| |
| *[[Blurred vision|Blurry vision]] or blind spots.
| |
| *Abdominal pain.
| |
|
| |
| ==== Less Common Symptoms ====
| |
| Less common symptoms of Waldenström macroglobulinemia include:<ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref><ref name="pmid12720138">{{cite journal| author=Merlini G, Baldini L, Broglia C, Comelli M, Goldaniga M, Palladini G et al.| title=Prognostic factors in symptomatic Waldenstrom's macroglobulinemia. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 211-5 | pmid=12720138 | doi=10.1053/sonc.2003.50064 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720138 }} </ref>
| |
| *Enlarged lymph nodes (appearing as 1-2 inches sized lumps under the skin in neck, groin or the armpits).
| |
| *Swollen belly/abdomen (due to hepatosplenomegaly).
| |
| *Pain or a feeling of fullness below the ribs on the left side.
| |
| *Painless lumps in the neck, underarm, stomach, or groin
| |
| *Headache.
| |
| *Raised pink/flesh-colored lesions on skin.
| |
| *Altered mental status due to decreased blood flow and infiltration of CNS leading to:
| |
| **[[Bing–Neel syndrome|Bing-Neel syndrome]] which includes:
| |
| ***[[Confusion]].
| |
| ***Dizziness.
| |
| ***[[Memory loss]].
| |
| ***[[Motor disorders]].
| |
| *Symptoms resembling stroke like slurred speech or weakness on one side of body (such patients are advised to consult from their doctor right away).
| |
| *Abnormal mucous membrane bleeding (epistaxis, bleeding gums).
| |
| *Vision problems (blurred vision, double vision or blind spots).
| |
| *Kidney problems (leading to weakness, trouble breathing and fluid buildup in body tissues associated with accumulation of excess salt, fluid and waste products in blood secondary to amyloidosis).
| |
| *Heart problems (Secondary to amyloidosis, build up of M protein in heart affects its pumping ability, and also the heart has to work harder to pump the thick blood ultimately leading to CHF with following symptoms).
| |
| **Palpitations.
| |
| **Feeling of tiredness and weakness.
| |
| **Cough.
| |
| **Shortness of breath.
| |
| **Rapid weight gain.
| |
| **Swelling of feet and legs.
| |
| *Infections (high levels of abnormal antibody in WM slows down the production of normal antibodies).
| |
| *Digestive problems due to deposition of IgM protein in the [[lamina propria]] of the [[intestinal wall]] include:
| |
| **Diarrhea.
| |
| **Poor absorption of vitamins.
| |
| **GIT bleeding/[[steatorrhea]] (blood in stools/dark stools).
| |
| *Sensitivity to cold ([[Raynaud's phenomenon]] due to [[cryoglobulinemia]] in 5% WM patients), which is associated with reduced blood flow leading to pain, itching, bluish discoloration or sores in following body parts:
| |
| **Tip of nose.
| |
| **Ears.
| |
| **Fingers.
| |
| **Toes.
| |
| *Cryoglobulinemia also leads to:
| |
| **Numbness and tingling in hands and feet.
| |
| **Joint aches.
| |
| **Small bruises.
| |
| **Skin ulcers.
| |
|
| |
| ==== Symptoms Secondary to Hyperviscosity Syndrome ====
| |
| The lymphoma cells make varying amounts of a monoclonal protein called immunoglobulin M (IgM, or macroglobulin). Higher amounts of this protein than normal in blood tends to make it thick leading to [[hyperviscosity syndrome]] which occurs in approximately 15-20% patients of WM. When blood becomes thick, it is harder for blood to flow through small blood vessels, and when this occurs, the condition is termed as Waldenstrom macroglobulinemia. This excess amount of IgM antibodies can be ultimately associated with circulatory problems leading to less blood flow to the brain, the eyes or other organs.Clinical manifestations of hyperviscosity syndrome occur only if serum [[viscosity]] is >4 centipoises and include:<ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref>
| |
| *Symptoms resembling those of [[stroke]].
| |
| * Retinal [[hemorrhage]] with [[Blurred vision|blurring of vision]]/loss of vision.
| |
| *[[Vertigo]].
| |
| *[[Dizziness]].
| |
| *[[Headache]].
| |
| *[[Loss of coordination]].
| |
| *[[Nystagmus]].
| |
| *[[Tinnitus]].
| |
| *[[Ataxia]].
| |
| * [[Bleeding]].
| |
| *Shortness of breath.
| |
| *Numbness and tingling of the fingers or toes (called peripheral neuropathy).
| |
| *Muscle weakness.
| |
| *Confusion.
| |
| *Not all people with WM develop hyperviscosity, cryoglobulins, or amyloidosis.
| |
|
| |
| ===Physical Examination===
| |
| ====General Appearance====
| |
| Patients with Waldenström macroglobulinemia are generally well-appearing.<ref name="aa">Waldenström's macroglobulinemia. MedlinePlus (2015) https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 15th, 2015</ref>
| |
|
| |
| ====Skin====
| |
| *Maculopapular lesions, plaques, or nodules.<ref name="pmid12883242">{{cite journal| author=Lin P, Bueso-Ramos C, Wilson CS, Mansoor A, Medeiros LJ| title=Waldenstrom macroglobulinemia involving extramedullary sites: morphologic and immunophenotypic findings in 44 patients. | journal=Am J Surg Pathol | year= 2003 | volume= 27 | issue= 8 | pages= 1104-13 | pmid=12883242 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12883242 }} </ref><ref name="pmid10188670">{{cite journal| author=Daoud MS, Lust JA, Kyle RA, Pittelkow MR| title=Monoclonal gammopathies and associated skin disorders. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 4 | pages= 507-35; quiz 536-8 | pmid=10188670 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10188670 }} </ref><ref name="pmid9198063">{{cite journal| author=Veltman GA, van Veen S, Kluin-Nelemans JC, Bruijn JA, van Es LA| title=Renal disease in Waldenström's macroglobulinaemia. | journal=Nephrol Dial Transplant | year= 1997 | volume= 12 | issue= 6 | pages= 1256-9 | pmid=9198063 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9198063 }} </ref>
| |
| *[[Purpura]].
| |
| *[[Raynaud phenomenon]].
| |
| *[[Petechiae]] (if platelet count is low).
| |
| *Skin ulcers.
| |
| *Skin necrosis.
| |
| *Cold urticaria.
| |
| *Firm, flesh-colored skin papules and nodules also called macroglobulinemia cutis.<ref name="pmid10188670">{{cite journal| author=Daoud MS, Lust JA, Kyle RA, Pittelkow MR| title=Monoclonal gammopathies and associated skin disorders. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 4 | pages= 507-35; quiz 536-8 | pmid=10188670 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10188670 }} </ref>
| |
|
| |
| ====HEENT====
| |
| *[[Pallor]].
| |
| *[[Papilledema]].
| |
| *Malignant vitreitis.<ref name="pmid6801795">{{cite journal| author=Orellana J, Friedman AH| title=Ocular manifestations of multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathy. | journal=Surv Ophthalmol | year= 1981 | volume= 26 | issue= 3 | pages= 157-69 | pmid=6801795 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6801795 }} </ref>
| |
| *Congestion/sludging of blood in conjunctival vessels.
| |
| *Retinitis/retinopathy including dilation, segmentation and tortuosity of retinal vessels, mid-peripheral retinal hemorrhages, serous retinal/macular neurosensory detachment, blurred disc margins and fundal exudates on fundoscopic examination.<ref name="pmid16044069">{{cite journal| author=Pilon AF, Rhee PS, Messner LV| title=Bilateral, persistent serous macular detachments with Waldenström's macroglobulinemia. | journal=Optom Vis Sci | year= 2005 | volume= 82 | issue= 7 | pages= 573-8 | pmid=16044069 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16044069 }} </ref><ref name="pmid2507620">{{cite journal| author=Avashia JH, Fath DF| title=Bilateral central retinal vein occlusion in Waldenström's macroglobulinemia. | journal=J Am Optom Assoc | year= 1989 | volume= 60 | issue= 9 | pages= 657-8 | pmid=2507620 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2507620 }} </ref><ref name="pmid3081619">{{cite journal| author=Goen TM, Terry JE| title=Mid-peripheral hemorrhages secondary to Waldenström's macroglobulinemia. | journal=J Am Optom Assoc | year= 1986 | volume= 57 | issue= 2 | pages= 109-12 | pmid=3081619 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3081619 }} </ref>
| |
|
| |
| ====Neck====
| |
| *[[Lymphadenopathy]].<ref name="DimopoulosPanayiotidis2000">{{cite journal|last1=Dimopoulos|first1=Meletios A.|last2=Panayiotidis|first2=Panayiotis|last3=Moulopoulos|first3=Lia A.|last4=Sfikakis|first4=Petros|last5=Dalakas|first5=Marinos|title=Waldenström’s Macroglobulinemia: Clinical Features, Complications, and Management|journal=Journal of Clinical Oncology|volume=18|issue=1|year=2000|pages=214–214|issn=0732-183X|doi=10.1200/JCO.2000.18.1.214}}</ref>
| |
| *[[Jugular venous distension]].
| |
|
| |
| ====Respiratory====
| |
| *[[Pleural effusion]] - in 3-5% of patients.<ref name="pmid9671845">{{cite journal| author=Fadil A, Taylor DE| title=The lung and Waldenström's macroglobulinemia. | journal=South Med J | year= 1998 | volume= 91 | issue= 7 | pages= 681-5 | pmid=9671845 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9671845 }} </ref>
| |
| *[[Rales]] on auscultation.
| |
| *Pulmonary infiltrates, nodules, masses.<ref name="pmid9671845">{{cite journal| author=Fadil A, Taylor DE| title=The lung and Waldenström's macroglobulinemia. | journal=South Med J | year= 1998 | volume= 91 | issue= 7 | pages= 681-5 | pmid=9671845 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9671845 }} </ref>
| |
|
| |
|
| ====Cardiovascular system====
| | [[Lymphoplasmacytic lymphoma diagnostic study of choice|Diagnostic study of choice]] | [[Lymphoplasmacytic lymphoma history and symptoms|History and Symptoms]] | [[Lymphoplasmacytic lymphoma physical examination|Physical Examination]] | [[Lymphoplasmacytic lymphoma laboratory findings|Laboratory Findings]] | [[Lymphoplasmacytic lymphoma electrocardiogram|Electrocardiogram]] | [[Lymphoplasmacytic lymphoma x ray|X-Ray Findings]] | [[Lymphoplasmacytic lymphoma echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Lymphoplasmacytic lymphoma CT scan|CT-Scan Findings]] | [[Lymphoplasmacytic lymphoma MRI|MRI Findings]] | [[Lymphoplasmacytic lymphoma other imaging findings|Other Imaging Findings]] | [[Lymphoplasmacytic lymphoma other diagnostic studies|Other Diagnostic Studies]] |
| *[[Apical impulse|Displaced apical impulse]].
| |
| *[[S3 gallop]].
| |
| | |
| ====Abdomen====
| |
| *Swollen abdomen/belly.
| |
| *[[Splenomegaly]].
| |
| *[[Hepatomegaly]].
| |
| | |
| ====Extremity====
| |
| *[[Raynaud phenomenon]].
| |
| *Patients may have [[peripheral edema]] if disease is complicated by [[congestive heart failure]].
| |
| | |
| ====Neuromuscular====
| |
| *[[Peripheral neuropathy]] - distal, symmetric, and sensorimotor.<ref name="cns">{{cite journal |vauthors=Coimbra J, Costa AP, Pita F, Rosado P, de Almeida LB |title=[Neuropathy in Waldenstrom's macroglobulinemia] |language=Portuguese |journal=Acta Med Port |volume=8 |issue=4 |pages=253–7 |year=1995 |pmid=7625222 |doi= |url=}}</ref>
| |
| | |
| ===Laboratory Findings===
| |
| WM is mostly suspected when a patient has low blood counts and/or high levels of unusual protein levels on blood tests. Then usually after that, a blood test called [[serum protein electrophoresis]] is ordered to find out what type of protein is there. And mostly, only after these tests are done that a biopsy of either the bone marrow or a lymph node is considered to confirm the WM diagnosis. Laboratory findings consistent with the diagnosis of Waldenström macroglobulinemia include:<ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref>
| |
| * '''Complete blood count:'''
| |
| **[[Anemia]].
| |
| ***Seen in 40% of newly diagnosed patients and in 80% of symptomatic patients with Waldenström's macroglobulinemia.
| |
| ***Multi-factorial causes including: decreased RBC synthesis due to [[bone marrow infiltration]], [[iron deficiency]] due to [[gastrointestinal bleeding]], and [[chronic inflammation]].
| |
| **[[Thrombocytopenia]].
| |
| ***Due to bone marrow infiltration.
| |
| ****
| |
| **[[Neutropenia]].
| |
| ***Due to bone marrow infiltration.
| |
| **[[Lymphocytosis]].
| |
| **[[Monocytosis]].
| |
| * '''Peripheral smear''':
| |
| **[[Plasmacytoid]] lymphocytes.
| |
| **[[Normocytic normochromic anemia|Normocytic normochromic red blood cells]].
| |
| **[[Rouleaux]] formation.
| |
| * '''Chemistry Lab tests:'''<ref name="pmid19520758">{{cite journal| author=Katzmann JA, Kyle RA, Benson J, Larson DR, Snyder MR, Lust JA et al.| title=Screening panels for detection of monoclonal gammopathies. | journal=Clin Chem | year= 2009 | volume= 55 | issue= 8 | pages= 1517-22 | pmid=19520758 | doi=10.1373/clinchem.2009.126664 | pmc=3773468 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19520758 }} </ref>
| |
| **Elevated [[lactate dehydrogenase]] (LDH).
| |
| ***Level indicates the extent of the disease.
| |
| **Elevated [[urea]] and [[creatinine]].
| |
| ***Rarely
| |
| **Electrolyte abnormalities:
| |
| ***[[Hypercalcemia]].
| |
| ***[[Hyponatremia]].
| |
| **Elevated [[erythrocyte sedimentation rate]] (ESR) and [[uric acid]].
| |
| **[[Rheumatoid factor]], [[cryoglobulins]], direct anti-globulin test, and [[cold agglutinin titre]] results can be positive.
| |
| **Elevated [[beta-2-microglobulin]] in proportion to tumor mass.
| |
| *** Needed to evaluate prognosis.
| |
| * '''Platelet function test and blood coagulation studies:'''
| |
| ** Prolonged bleeding time.<ref name="pmid4924493">{{cite journal| author=Penny R, Castaldi PA, Whitsed HM| title=Inflammation and haemostasis in paraproteinaemias. | journal=Br J Haematol | year= 1971 | volume= 20 | issue= 1 | pages= 35-44 | pmid=4924493 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4924493 }} </ref>
| |
| *** Possibly due to interaction between [[platelet]] membrane [[Glycoprotein|glycoproteins]] and [[IgM]] [[paraprotein]].
| |
| ** Abnormalities in [[prothrombin time]], [[activated partial thromboplastin time]], [[thrombin time]], and [[fibrinogen]].
| |
| * '''Mutational analysis:''' The ''[[MYD88]]'' gene mutation has been found in more than 90% of patients with Waldenstrom's macroglobulinemia.<ref name="pmid23321251">{{cite journal| author=Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X et al.| title=MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. | journal=Blood | year= 2013 | volume= 121 | issue= 11 | pages= 2051-8 | pmid=23321251 | doi=10.1182/blood-2012-09-454355 | pmc=3596964 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23321251 }} </ref>
| |
| *'''Cryocrit:'''
| |
| **This test measures the blood levels of cryoglobulins (proteins that clump together in cool temperatures and can block blood vessels).
| |
| *'''Cold agglutinins:'''
| |
| **Cold agglutinins are antibodies that attack and kill red blood cells, especially at cooler temperatures. These dead cells can then build up and block blood vessels. A blood test can be used to detect these antibodies.
| |
| *'''Beta-2 microglobulin (β2M):'''
| |
| **This test measures another protein made by the cancer cells in WM. This protein itself doesn’t cause any problems, but it’s a useful indicator of a patient’s prognosis (outlook). High levels of β2M are linked with a worse outlook.
| |
| *'''Urinanalysis:'''
| |
| **Proteinuria.
| |
| ===Bone Marrow Aspirate===
| |
| A [[Bone marrow aspiration|bone marrow aspirate]] is essential in the diagnosis of Waldenström macroglobulinemia.
| |
| | |
| Findings suggestive of Waldenström macroglobulinemia include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | |
| * A hypercellular bone marrow aspirate.
| |
| * Lymphoplasmacytic infiltrate with characteristic immunophenotype.
| |
| === Bone Marrow Biopsy ===
| |
| A [[bone marrow biopsy]] may be helpful in the diagnosis of Waldenström macroglobulinemia. <ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref>
| |
| | |
| Findings on the biopsy suggestive of Waldenström macroglobulinemia include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref>
| |
| * Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]].
| |
| | |
| * Dutcher bodies (PAS positive intra-nuclear vacuoles containing IgM monoclonal protein).
| |
| ** Characteristic feature of Waldenström macroglobulinemia.
| |
| Three patterns of marrow involvement are described, as follows:
| |
| * Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern.
| |
| * Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern.
| |
| * A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures).
| |
| ===Electrophoresis and Immunofixation===
| |
| [[Serum protein electrophoresis]] is important for the diagnosis of Waldenström's macroglobulinemia.
| |
| | |
| Findings on an electrophoresis diagnostic of Waldenström's macroglobulinemia include:<ref name="pmid1872571">{{cite journal| author=Riches PG, Sheldon J, Smith AM, Hobbs JR| title=Overestimation of monoclonal immunoglobulin by immunochemical methods. | journal=Ann Clin Biochem | year= 1991 | volume= 28 ( Pt 3) | issue= | pages= 253-9 | pmid=1872571 | doi=10.1177/000456329102800310 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1872571 }} </ref>
| |
| *Sharp, narrow spike of monoclonal [[IgM]] protein
| |
| *Dense band of monoclonal IgM protein
| |
| *The [[paraprotein]] can be of any size
| |
| | |
| Serum immunofixation is important for the diagnosis of Waldenström's macroglobulinemia. It helps in confirming the presence of a [[Monoclonal|monoclonal protein]], in addition to determining its type.<ref name="pmid1872571">{{cite journal| author=Riches PG, Sheldon J, Smith AM, Hobbs JR| title=Overestimation of monoclonal immunoglobulin by immunochemical methods. | journal=Ann Clin Biochem | year= 1991 | volume= 28 ( Pt 3) | issue= | pages= 253-9 | pmid=1872571 | doi=10.1177/000456329102800310 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1872571 }} </ref>
| |
| | |
| ===Electrocardiogram===
| |
| There are no ECG findings associated with Waldenström macroglobulinemia.
| |
| | |
| ===X-ray===
| |
| Key Chest X-Ray Findings in Waldenström's Macroglobulinemia:
| |
| *[[Chest X-ray|Chest x-ray]] may be used to evaluate the following:<ref name="X-ray">{{cite journal |vauthors=Rausch PG, Herion JC |title=Pulmonary manifestations of Waldenstrom macroglobulinemia |journal=Am. J. Hematol. |volume=9 |issue=2 |pages=201–9 |year=1980 |pmid=6776807 |doi= |url=}}</ref>
| |
| **Enlarged lymph nodes.
| |
| **Pulmonary infiltrates: This is especially important in patients who are [[immunocompromised]] while receiving chemotherapy.
| |
| **Nodules.
| |
| **Effusion.
| |
| **Cardiomegaly (due to Congestive heart failure).
| |
| | |
| ===Echocardiography or Ultrasound===
| |
| There are no echocardiography and ultrasound findings associated with Waldenström's macroglobulinemia. However, ultrasound of the spleen is more accurate at quantitation compared to physical examination findings alone. Ultrasound can be used to look at lymph nodes near body surface or to look for enlarged abdominal lymph nodes or organs such as the liver, spleen, and kidneys. (It can’t be used to look at organs or lymph nodes in the chest because the ribs block the sound waves.) It is sometimes used to help guide a biopsy needle into an enlarged lymph node.
| |
| | |
| ===CT scan===
| |
| *CT scan imaging of chest, abdomen, and pelvis can be done to measure the tumor load.<ref name="ct">{{cite journal |vauthors=Banwait R, O'Regan K, Campigotto F, Harris B, Yarar D, Bagshaw M, Leleu X, Leduc R, Ramaiya N, Weller E, Ghobrial IM |title=The role of 18F-FDG PET/CT imaging in Waldenstrom macroglobulinemia |journal=Am. J. Hematol. |volume=86 |issue=7 |pages=567–72 |year=2011 |pmid=21681781 |doi=10.1002/ajh.22044 |url=}}</ref>
| |
| *Waldenström's macroglobulinemia shows evidence of [[lymphadenopathy]], and [[hepatosplenomegaly]].<ref name="ct" />
| |
| *CT of the lungs or abdomen can also be diagnostic for infection, which is particularly relevant to [[immunocompromised]] patients.
| |
| | |
| ===MRI===
| |
| There are no specific MRI findings associated with Waldenström macroglobulinemia. However, MRI of the brain, spinal cord and orbits is important when assessing for hyperviscosity in the presence of high IgM paraprotein in the blood.
| |
| | |
| ===PET scan===
| |
| A PET scan can be helpful in spotting small collections of cancer cells. It is even more valuable when combined with a CT scan (PET/CT scan). PET scans also can help tell if an enlarged lymph node contains lymphoma or not. It can help spot small areas that might be lymphoma, even if the area looks normal on a CT scan. These tests can be used to tell if a lymphoma is responding to treatment. They can also be used after treatment to help decide whether an enlarged lymph node still contains lymphoma or is merely scar tissue.
| |
| | |
| ===Other Diagnostic Studies===
| |
| Other diagnostic studies for Waldenström macroglobulinemia include:
| |
| *'''[[Nerve conduction study|Nerve conduction]] study''' and '''[[electromyography]]''', which demonstrates:<ref name="ser">{{cite journal |vauthors=Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, Barbieri S, Moggio M, Polli N, Polli E, Scarlato G |title=Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins |journal=Neurology |volume=37 |issue=9 |pages=1506–14 |year=1987 |pmid=2442666 |doi= |url=}}</ref>
| |
| **[[Demyelination]] with sensory involvement more than motor
| |
| *'''[[Fundoscopy]]''', which demonstrates:<ref name="pmid27378193">{{cite journal| author=Castillo JJ, Garcia-Sanz R, Hatjiharissi E, Kyle RA, Leleu X, McMaster M et al.| title=Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia. | journal=Br J Haematol | year= 2016 | volume= 175 | issue= 1 | pages= 77-86 | pmid=27378193 | doi=10.1111/bjh.14196 | pmc=5154335 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27378193 }} </ref>
| |
| **Dilated, segmented, and tortuous [[retinal veins]] giving a "sausage link" appearance
| |
| ***Useful in patients with suspected [[hyperviscosity syndrome]]
| |
| * '''Plasma viscosity''', which demonstrates:<ref name="pmid4014299">{{cite journal| author=Crawford J, Cox EB, Cohen HJ| title=Evaluation of hyperviscosity in monoclonal gammopathies. | journal=Am J Med | year= 1985 | volume= 79 | issue= 1 | pages= 13-22 | pmid=4014299 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4014299 }} </ref>
| |
| **Values > 1.5 centipoise
| |
| ***Should be measured in patients presenting with signs and symptoms suggestive of hyperviscosity syndrome or whenever the monoclonal [[Immunoglobulin M|IgM]] protein spike is > 4 g/dL.
| |
| * '''Mutational analysis''' for the ''[[MYD88]]'' gene, since the MYD88 L265P mutation is found in 90% of patients with Waldenstrom's macroglobulinemia<ref name="pmid23321251">{{cite journal| author=Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X et al.| title=MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. | journal=Blood | year= 2013 | volume= 121 | issue= 11 | pages= 2051-8 | pmid=23321251 | doi=10.1182/blood-2012-09-454355 | pmc=3596964 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23321251 }} </ref>
| |
|
| |
|
| ==Treatment== | | ==Treatment== |
| There are several different options for treating Waldenström macroglobulinemia depending on stage of the disease:<ref name="Tx">Lymphoplasmacytic lymphoma. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/lymphoplasmacytic-lymphoma/?region=ab Accessed on November 6 2015 </ref>
| | [[Lymphoplasmacytic lymphoma medical therapy|Medical Therapy]] | [[Lymphoplasmacytic lymphoma surgery|Surgery]] | [[Lymphoplasmacytic lymphoma primary prevention|Primary Prevention]] | [[Lymphoplasmacytic lymphoma secondary prevention|Secondary Prevention]] | [[Lymphoplasmacytic lymphoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Lymphoplasmacytic lymphoma future or investigational therapies|Future or Investigational Therapies]] |
| | |
| ====Asymptomatic/Smoldering Waldenström's Macroglobulinemia====
| |
| There is no treatment for asymptomatic Waldenström macroglobulinemia. Asymptomatic waldenström's macroglobulinemia can be monitored every 3-6 months.<ref name="BM">Waldenström's macroglobulinemia. Patient (2015)http://patient.info/doctor/waldenstroms-macroglobulinaemia-pro Accessed on November 10, 2015</ref> Active surveillance includes monitoring of the following laboratory parameters:
| |
| *Complete blood count ([[Complete blood count|CBC]]) with differential
| |
| *Complete metabolic panel ([[CMP-N-acetylneuraminate monooxygenase|CMP]])
| |
| *Immunoglobulin levels in the serum (quantitative)
| |
| *Serum protein electrophoresis
| |
| | |
| ====Symptomatic Waldenström's Macroglobulinemia====
| |
| Symptomatic patients with waldenström macroglobulinemia are started on chemotherapy depending on the stage.<ref name="ADR">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015)http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
| |
| | |
| *Initial stage of waldenström's macroglobulinemia associated with:
| |
| :*[[Neuropathy]]
| |
| :*[[Anemia]] or [[cytopenias]]
| |
| :*Low-volume nodal involvement
| |
| :*Asymptomatic [[splenomegaly]]
| |
| | |
| *Late stage of Waldenström's macroglobulinemia associated with:
| |
| :*[[Adenopathy]]
| |
| :*Symptomatic [[splenomegaly]]
| |
| :*[[Cytopenia|Cytopenias]]
| |
| :*[[Hyperviscosity syndrome]]
| |
| :*[[Neuropathy]]
| |
| :*Constitutional symptoms
| |
| | |
| {| style="border: 0px; font-size: 90%; margin: 3px; width: 800px"
| |
| | valign="top" |
| |
| |+
| |
| ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Treatment Regimen<ref name="ADR">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015)http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
| |
| }}
| |
| ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Drugs}}
| |
| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Side effects}}
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''[[CHOP-R regimen]]'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" | | |
| *[[Cyclophosphamide]]
| |
| *[[Doxorubicin]]
| |
| *[[Vincristine]]
| |
| *[[Prednisone]]
| |
| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Nausea]]
| |
| *[[Alopecia]]
| |
| *[[Granulocytopenia]]
| |
| *[[Cardiotoxicity]]
| |
| *[[Mucositis]]
| |
| |- | |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''[[Ibrutinib]]'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Ibrutinib]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Fatigue]]
| |
| *[[Cytopenia]]
| |
| *[[Bleeding]]
| |
| *[[Atrial fibrillation]]
| |
| *[[Opportunistic infection]]
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''[[Rituximab]]'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *Infusion related reaction
| |
| *[[Hepatitis B]] reaction
| |
| *Progressive multi-focal leukoencephaloptahy
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | |
| '''FR regimen'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Fludarabine]]
| |
| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Neutropenia]] (63%)
| |
| *[[Thrombocytopenia]]
| |
| *[[Pneumonia]]
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''BDR regimen'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Bortezomib]]
| |
| *[[Dexamethasone]]
| |
| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Peripheral neuropathy]] - reversible in 61% of patients
| |
| *[[Infections]]
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | |
| '''DRC regimen'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Dexamethasone]]
| |
| *[[Rituximab]]
| |
| *[[Cyclophosphamide]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Neutropenia]]
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''CR regimen'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Cladribine]]
| |
| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Anemia]]
| |
| *Neurological symptoms
| |
| *Symptomatic [[cryoglobulinemia]]
| |
| *[[Thrombocytopenia]]
| |
| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''IR regimen'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Ibrutinib]]
| |
| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Anemia]]
| |
| *Neurological symptoms
| |
| *Symptomatic [[cryoglobulinemia]]
| |
| *[[Thrombocytopenia]]
| |
| *[[Atrial fibrillation]]
| |
| |-
| |
| |} | |
| | |
| ====Hyperviscosity syndrome====
| |
| *Waldenström macroglobulinemia complicated with [[hyperviscosity syndrome]] is a medical emergency and requires prompt treatment with plasmapheresis.<ref name="ADR">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015)http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
| |
| *[[Plasmapheresis]] temporarily lowers [[IgM]] levels by removing some of the abnormal IgM from the blood, which makes blood thinner.
| |
| *Plasmapheresis is usually given until chemotherapy starts to work.
| |
| *Plasmapheresis is combined with chemotherapy to control the disease for a longer period of time.
| |
| ===Surgery===
| |
| [[Stem cell transplant]] is usually reserved for patients with either relapse or refractory Waldenström's macroglobulinemia.<ref name="sure">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015) http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
| |
| ===Primary Prevention===
| |
| Primary prevention of Waldenström macroglobulinemia depends on the type of risk factor causing the disease.<ref name="PP">Waldenström's macroglobulinemia. American Cancer Society. (2015)http://www.cancer.org/cancer/waldenstrommacroglobulinemia/detailedguide/waldenstrom-macroglobulinemia-prevention Accessed on November 11, 2015</ref>
| |
| ===Modifiable risk factors===
| |
| *[[Hepatitis C]]
| |
| ===Non-modifiable risk factors===
| |
| *Age > 50
| |
| *Male gender
| |
| *Race - White
| |
| *Hereditary- [[Monoclonal gammopathy of undetermined significance]]
| |
| ===Secondary Prevention===
| |
| There are no established measures for the secondary prevention of Waldenström's macroglobulinemia.
| |
| | |
| One or more of the following treatments can be given for lymphoplasmacytic lymphoma.
| |
| ===Watchful waiting===
| |
| Watchful waiting (also called active surveillance) may be offered for lymphoplasmacytic lymphoma because it develops slowly and may not need to be treated right away. The healthcare team will carefully monitor the person with lymphoplasmacytic lymphoma and start treatment when symptoms appear, such as hyperviscosity syndrome, or there are signs that the disease is progressing more quickly.
| |
| ===Chemotherapy===
| |
| *People with lymphoplasmacytic lymphoma who have symptoms or hyperviscosity syndrome are usually given chemotherapy. Chemotherapy drugs that may be used with or without prednisone include:
| |
| **Chlorambucil (Leukeran)
| |
| **Fludarabine (Fludara)
| |
| **Bendamustine (Treanda)
| |
| **Cyclophosphamide (Cytoxan, Procytox)
| |
| | |
| *Combinations of chemotherapy drugs that may be used include:
| |
| **DRC – dexamethasone (Decadron, Dexasone), rituximab (Rituxan) and cyclophosphamide
| |
| **BRD – bortezomib (Velcade) and rituximab, with or without dexamethasone
| |
| **CVP – cyclophosphamide, vincristine (Oncovin) and prednisone
| |
| **R-CVP – CVP with rituximab
| |
| **Thalidomide (Thalomid) and rituximab
| |
| | |
| ===Targeted therapy===
| |
| *Targeted therapy uses drugs to target specific molecules (such as proteins) on the surface of cancer cells. These molecules help send signals that tell cells to grow or divide. By targeting these molecules, the drugs stop the growth and spread of cancer cells while limiting harm to normal cells.
| |
| *Targeted therapy drugs used alone or in combination to treat lymphoplasmacytic lymphoma include rituximab, bortezomib and ibrutinib (Imbruvica).
| |
| ===Immunotherapy===
| |
| *Immunotherapy works by stimulating, boosting, restoring or acting like the body’s immune system to create a response against cancer cells. Immunomodulatory drugs are a type of immunotherapy that interferes with the growth and division of cancer cells.
| |
| *Thalidomide is a type of immunomodulatory drug that may be used to treat lymphoplasmacytic lymphoma.
| |
| ===Radiation therapy===
| |
| External beam radiation therapy may be used to treat lymphoplasmacytic lymphoma that develops outside of the lymphatic system (called extralymphatic disease), but this is rare.
| |
| ===Stem cell transplant===
| |
| *Some people with lymphoplasmacytic lymphoma may be offered a stem cell transplant.
| |
| *It may be used if the lymphoma comes back (recurs) after treatment or doesn’t respond to other treatments (called refractory disease).
| |
| *Many people with lymphoplasmacytic lymphoma are older or may not be in good health, so a stem cell transplant may not be a good treatment option for them.
| |
|
| |
|
| | ==Case Studies== |
| | [[Lymphoplasmacytic lymphoma case study one|Case #1]] |
|
| |
|
| Read more: http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/more-types-of-nhl/lymphoplasmacytic-lymphoma/?region=on#ixzz5eb6iT7G6
| | [[Category: (name of the system)]] |
| ==References==
| |
| {{reflist|2}}
| |