Oligodendroglioma pathophysiology: Difference between revisions

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{{CMG}}{{AE}}{{SR}}
{{Oligodendroglioma}}
{{Oligodendroglioma}}
{{CMG}}{{AE}}{{S.M.}}{{SR}}


==Overview==
==Overview==
[[Oligodendroglioma]] arises from the tripotential [[Glial cell|glial precursor cells]] and ''not'' from the [[bipotential]] [[Oligodendrocyte|oligodendrocytes]]. [[Genes]] [[Association (statistics)|associated]] with the [[pathogenesis]] of [[oligodendroglioma]] include [[Translocation|t[1;19][q10;p10]]], [[ATRX]], ''[[Mutation|NJDS]]'', ''[[Isocitrate dehydrogenase|IDH1]]'', ''[[IDH2]]'', [[TERT]] [[promoter]], [[H3F3A|H3]] K27M (''[[H3F3A]], [[HIST1H3B]]/[[HIST1H3C|C]]),'' ''[[CIC (gene)|CIC]]'', ''[[Far upstream element-binding protein 1|FUBP1]]'', ''[[p53]]'', ''[[CD57|Leu-7]]'', ''[[TCF12|TCF-12]]'', ''[[TP53]],[[Ogt|MGMT]]'', ''[[P73|TP73]]'', [[BRAF]], ''[[EGFR]]'', and ''[[PTEN]]''. Common intracranial sites involved by [[oligodendroglioma]] include [[Cerebral hemisphere|cerebral hemispheres]], [[posterior fossa]], and [[Spinal cord|intramedullary spinal cord]]. On [[gross pathology]], [[oligodendroglioma]] is characterized by a well-circumscribed, gelatinous, [[Calcified lesion|calcified]], [[cystic]], [[gray]] [[mass]] with focal [[hemorrhage]] which may expand a [[gyrus]] and remodel the [[skull]]. On [[microscopic]] [[histopathological]] [[analysis]], [[oligodendroglioma]] is characterized by [[diffuse]] [[growth]][[pattern]] of highly [[cellular]] [[lesion]] of monomorphic [[Cells (biology)|cells]] having rounded [[nucleus]] with [[atypia]], speckled "''[[salt]]-and-[[Pepper spray|pepper]]''" [[chromatin]] [[pattern]] and [[Perinuclear space|perinuclear]] [[Halo (medicine)|halo]]<nowiki/>resembling ''fried [[Egg (biology)|eggs]]'', [[Distinctive feature|distinct]] [[Cell (biology)|cell]] borders, clear [[cytoplasm]], abundant [[calcification]] and "''chicken-wire''" like [[vascularity]] [[pattern]]. [[Oligodendroglioma]] is demonstrated by [[Positivity effect|positivity]] to [[tumor markers]] such as [[Isocitrate dehydrogenase|IDH1-R132H]], [[Microtubule-associated protein|MAP2]], [[GFAP]], [[S100 calcium binding protein A8|S-100]], [[SOX10]], EMA, [[ATRX]], [[Ki-67 (Biology)|Ki-67]], [[Neuron-Specific Enolase (NSE)|NSE]], [[synaptophysin]], [[OLIG1]], and [[OLIG2]].
==Pathophysiology==
==Pathophysiology==
===Pathogenesis===
===Pathogenesis===
*Oligodendroglioma does ''not'' arise from the bipotential [[oligodendrocyte]]s, although [[tumor]] cells look very similiar.<ref name=pathogenesis>General features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma#cite_note-1</ref>
*[[Oligodendroglioma]] does ''not'' arise from the [[bipotential]] [[oligodendrocyte]]s, although the [[tumor]] [[Cells (biology)|cells]] look very similiar.<ref name="pathogenesis">General features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma#cite_note-1</ref>
*Oligodendroglioma arises from the tripotential [[glial cell|glial precursor cells]].
*[[Oligodendroglioma]] arises from the tripotential [[glial cell|glial precursor cells]].


===Genetics===
===Genetics===
*Development of oligodendroglioma is the result from multiple [[mutation|genetic mutations]].
*[[Development]] of [[oligodendroglioma]] is the [[result]] of multiple [[mutation|genetic mutations.]]<ref name="pmid25848751">{{cite journal| author=Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y et al.| title=Mutational landscape and clonal architecture in grade II and III gliomas. | journal=Nat Genet | year= 2015 | volume= 47 | issue= 5 | pages= 458-68 | pmid=25848751 | doi=10.1038/ng.3273 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25848751 }} </ref><ref name="pmid26210286">{{cite journal| author=Leeper HE, Caron AA, Decker PA, Jenkins RB, Lachance DH, Giannini C| title=IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas. | journal=Oncotarget | year= 2015 | volume= 6 | issue= 30 | pages= 30295-305 | pmid=26210286 | doi=10.18632/oncotarget.4497 | pmc=4745799 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26210286 }} </ref><ref name="pmid24470545">{{cite journal| author=Sabha N, Knobbe CB, Maganti M, Al Omar S, Bernstein M, Cairns R et al.| title=Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas. | journal=Neuro Oncol | year= 2014 | volume= 16 | issue= 7 | pages= 914-23 | pmid=24470545 | doi=10.1093/neuonc/not299 | pmc=4057130 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24470545 }} </ref><ref name="pmid23583981">{{cite journal| author=Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B et al.| title=Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. | journal=Nat Genet | year= 2013 | volume= 45 | issue= 6 | pages= 602-12 | pmid=23583981 | doi=10.1038/ng.2611 | pmc=3727232 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23583981 }} </ref><ref name="pmid24705251">{{cite journal| author=Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y et al.| title=The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. | journal=Nat Genet | year= 2014 | volume= 46 | issue= 5 | pages= 444-450 | pmid=24705251 | doi=10.1038/ng.2938 | pmc=4056452 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24705251 }} </ref><ref name="pmid26671986">{{cite journal| author=Tanboon J, Williams EA, Louis DN| title=The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas. | journal=J Neuropathol Exp Neurol | year= 2016 | volume= 75 | issue= 1 | pages= 4-18 | pmid=26671986 | doi=10.1093/jnen/nlv009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26671986 }} </ref><ref name="pmid22869205">{{cite journal| author=Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF et al.| title=Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. | journal=Oncotarget | year= 2012 | volume= 3 | issue= 7 | pages= 709-22 | pmid=22869205 | doi=10.18632/oncotarget.588 | pmc=3443254 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22869205  }} </ref><ref name="pmid22588899">{{cite journal| author=Sahm F, Koelsche C, Meyer J, Pusch S, Lindenberg K, Mueller W et al.| title=CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. | journal=Acta Neuropathol | year= 2012 | volume= 123 | issue= 6 | pages= 853-60 | pmid=22588899 | doi=10.1007/s00401-012-0993-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22588899  }} </ref><ref name="pmid15709179">{{cite journal| author=Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M| title=Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. | journal=Clin Cancer Res | year= 2005 | volume= 11 | issue= 3 | pages= 1119-28 | pmid=15709179 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15709179  }} </ref><ref name="pmid23681562">{{cite journal| author=Frenel JS, Leux C, Loussouarn D, Le Loupp AG, Leclair F, Aumont M et al.| title=Combining two biomarkers, IDH1/2 mutations and 1p/19q codeletion, to stratify anaplastic oligodendroglioma in three groups: a single-center experience. | journal=J Neurooncol | year= 2013 | volume= 114 | issue= 1 | pages= 85-91 | pmid=23681562 | doi=10.1007/s11060-013-1152-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23681562  }} </ref><ref name="pmid27651340">{{cite journal| author=Hacisalihoglu P, Kucukodaci Z, Gundogdu G, Bilgic B| title=The Correlation Between 1p/19q Codeletion, IDH1 Mutation, p53 Overexpression and Their Prognostic Roles in 41 Turkish Anaplastic Oligodendroglioma Patients. | journal=Turk Neurosurg | year= 2017 | volume= 27 | issue= 5 | pages= 682-689 | pmid=27651340 | doi=10.5137/1019-5149.JTN.16832-15.1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27651340  }} </ref>
*Genes associated with the pathogenesis of oligodendroglioma include:<ref name=transloc>Molecular genetics of oligodendroglioma. https://en.wikipedia.org/wiki/Oligodendroglioma</ref><ref name="pmid21817013">{{cite journal| author=Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH et al.| title=Mutations in CIC and FUBP1 contribute to human oligodendroglioma. | journal=Science | year= 2011 | volume= 333 | issue= 6048 | pages= 1453-5 | pmid=21817013 | doi=10.1126/science.1210557 | pmc=PMC3170506 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21817013 }} </ref><ref name=prog>Prognosis and treatment of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma</ref><ref name="pmid22072542">{{cite journal| author=Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J et al.| title=Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. | journal=J Pathol | year= 2012 | volume= 226 | issue= 1 | pages= 7-16 | pmid=22072542 | doi=10.1002/path.2995 | pmc=PMC3246739 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22072542 }} </ref><ref name="pmid26068201">{{cite journal| author=Labreche K, Simeonova I, Kamoun A, Gleize V, Chubb D, Letouzé E et al.| title=TCF12 is mutated in anaplastic oligodendroglioma. | journal=Nat Commun | year= 2015 | volume= 6 | issue= | pages= 7207 | pmid=26068201 | doi=10.1038/ncomms8207 | pmc=PMC4490400 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26068201 }} </ref><ref name="pmid21937591">{{cite journal| author=Suri V, Jha P, Agarwal S, Pathak P, Sharma MC, Sharma V et al.| title=Molecular profile of oligodendrogliomas in young patients. | journal=Neuro Oncol | year= 2011 | volume= 13 | issue= 10 | pages= 1099-106 | pmid=21937591 | doi=10.1093/neuonc/nor146 | pmc=PMC3177666 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21937591 }} </ref><ref name="pmid9038605">{{cite journal| author=Hagel C, Laking G, Laas R, Scheil S, Jung R, Milde-Langosch K et al.| title=Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas. | journal=Eur J Cancer | year= 1996 | volume= 32A | issue= 13 | pages= 2242-8 | pmid=9038605 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9038605 }} </ref><ref name="pmiddoi:10.1016/S0090-3019(03)00167-8">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=doi:10.1016/S0090-3019(03)00167-8 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref><ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>
*[[Genes]] [[Association (statistics)|associated]] with the [[pathogenesis]] of [[oligodendroglioma]] include:<ref name="transloc">Molecular genetics of oligodendroglioma. https://en.wikipedia.org/wiki/Oligodendroglioma</ref><ref name="pmid21817013">{{cite journal| author=Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH et al.| title=Mutations in CIC and FUBP1 contribute to human oligodendroglioma. | journal=Science | year= 2011 | volume= 333 | issue= 6048 | pages= 1453-5 | pmid=21817013 | doi=10.1126/science.1210557 | pmc=PMC3170506 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21817013  }} </ref><ref name="prog">Prognosis and treatment of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma</ref><ref name="pmid22072542">{{cite journal| author=Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J et al.| title=Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. | journal=J Pathol | year= 2012 | volume= 226 | issue= 1 | pages= 7-16 | pmid=22072542 | doi=10.1002/path.2995 | pmc=PMC3246739 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22072542  }} </ref><ref name="pmid26068201">{{cite journal| author=Labreche K, Simeonova I, Kamoun A, Gleize V, Chubb D, Letouzé E et al.| title=TCF12 is mutated in anaplastic oligodendroglioma. | journal=Nat Commun | year= 2015 | volume= 6 | issue=  | pages= 7207 | pmid=26068201 | doi=10.1038/ncomms8207 | pmc=PMC4490400 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26068201  }} </ref><ref name="pmid21937591">{{cite journal| author=Suri V, Jha P, Agarwal S, Pathak P, Sharma MC, Sharma V et al.| title=Molecular profile of oligodendrogliomas in young patients. | journal=Neuro Oncol | year= 2011 | volume= 13 | issue= 10 | pages= 1099-106 | pmid=21937591 | doi=10.1093/neuonc/nor146 | pmc=PMC3177666 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21937591  }} </ref><ref name="pmid9038605">{{cite journal| author=Hagel C, Laking G, Laas R, Scheil S, Jung R, Milde-Langosch K et al.| title=Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas. | journal=Eur J Cancer | year= 1996 | volume= 32A | issue= 13 | pages= 2242-8 | pmid=9038605 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9038605  }} </ref><ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref><ref name="pmid26061751">{{cite journal| author=Cancer Genome Atlas Research Network. Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR et al.| title=Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. | journal=N Engl J Med | year= 2015 | volume= 372 | issue= 26 | pages= 2481-98 | pmid=26061751 | doi=10.1056/NEJMoa1402121 | pmc=4530011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26061751  }} </ref><ref name="pmid26061753">{{cite journal| author=Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H et al.| title=Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. | journal=N Engl J Med | year= 2015 | volume= 372 | issue= 26 | pages= 2499-508 | pmid=26061753 | doi=10.1056/NEJMoa1407279 | pmc=4489704 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26061753  }} </ref><ref name="pmid11801559">{{cite journal| author=Ueki K, Nishikawa R, Nakazato Y, Hirose T, Hirato J, Funada N et al.| title=Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors. | journal=Clin Cancer Res | year= 2002 | volume= 8 | issue= 1 | pages= 196-201 | pmid=11801559 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11801559  }} </ref><ref name="pmid25150284">{{cite journal| author=Labussière M, Boisselier B, Mokhtari K, Di Stefano AL, Rahimian A, Rossetto M et al.| title=Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes. | journal=Neurology | year= 2014 | volume= 83 | issue= 13 | pages= 1200-6 | pmid=25150284 | doi=10.1212/WNL.0000000000000814 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25150284  }} </ref><ref name="pmid30030640">{{cite journal| author=Nambirajan A, Suri V, Kedia S, Goyal K, Malgulwar PB, Khanna G et al.| title=Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harbouring chromosome 1p/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications. | journal=Brain Tumor Pathol | year= 2018 | volume= 35 | issue= 3 | pages= 186-191 | pmid=30030640 | doi=10.1007/s10014-018-0325-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30030640  }} </ref>
 
:*[[translocation|t(1;19)(q10;p10)]] (co-[[Deletion (genetics)|deletion]] of [[chromosomal]] arms [[chromosome 1|1p]]36 and [[chromosome 19|19q]]13; most common)<ref name="pmid16088966">{{cite journal| author=McDonald JM, See SJ, Tremont IW, Colman H, Gilbert MR, Groves M et al.| title=The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors. | journal=Cancer | year= 2005 | volume= 104 | issue= 7 | pages= 1468-77 | pmid=16088966 | doi=10.1002/cncr.21338 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16088966  }} </ref><ref name="pmid15709179">{{cite journal| author=Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M| title=Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. | journal=Clin Cancer Res | year= 2005 | volume= 11 | issue= 3 | pages= 1119-28 | pmid=15709179 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15709179  }} </ref><ref name="pmid7977648">{{cite journal| author=Reifenberger J, Reifenberger G, Liu L, James CD, Wechsler W, Collins VP| title=Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. | journal=Am J Pathol | year= 1994 | volume= 145 | issue= 5 | pages= 1175-90 | pmid=7977648 | doi= | pmc=1887413 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7977648  }} </ref>
:*[[translocation|t[1;19][q10;p10]]] (co-deletion of chromosomal arms [[chromosome 1|1p]] and [[chromosome 19|19q]]; most common)
:*[[ATRX]]<ref name="pmid25427834">{{cite journal| author=Reuss DE, Sahm F, Schrimpf D, Wiestler B, Capper D, Koelsche C et al.| title=ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 1 | pages= 133-46 | pmid=25427834 | doi=10.1007/s00401-014-1370-3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25427834  }} </ref>
:*''[[mutation|NJDS]]''
:*''[[Isocitrate dehydrogenase|IDH1]]''<ref name="pmid27780605">{{cite journal| author=Chen N, Yu T, Gong J, Nie L, Chen X, Zhang M et al.| title=IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients. | journal=Pathology | year= 2016 | volume= 48 | issue= 7 | pages= 675-683 | pmid=27780605 | doi=10.1016/j.pathol.2016.07.010 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27780605  }} </ref><ref name="pmid22113362">{{cite journal| author=Zhou YX, Wang JX, Feng M, Sun CM, Sun T, Chen GL et al.| title=Analysis of isocitrate dehydrogenase 1 mutation in 97 patients with glioma. | journal=J Mol Neurosci | year= 2012 | volume= 47 | issue= 3 | pages= 442-7 | pmid=22113362 | doi=10.1007/s12031-011-9681-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22113362  }} </ref><ref name="pmid19903171">{{cite journal| author=Capper D, Weissert S, Balss J, Habel A, Meyer J, Jäger D et al.| title=Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. | journal=Brain Pathol | year= 2010 | volume= 20 | issue= 1 | pages= 245-54 | pmid=19903171 | doi=10.1111/j.1750-3639.2009.00352.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19903171  }} </ref><ref name="pmid19228619">{{cite journal| author=Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W et al.| title=IDH1 and IDH2 mutations in gliomas. | journal=N Engl J Med | year= 2009 | volume= 360 | issue= 8 | pages= 765-73 | pmid=19228619 | doi=10.1056/NEJMoa0808710 | pmc=2820383 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19228619  }} </ref><ref name="pmid18985363">{{cite journal| author=Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A| title=Analysis of the IDH1 codon 132 mutation in brain tumors. | journal=Acta Neuropathol | year= 2008 | volume= 116 | issue= 6 | pages= 597-602 | pmid=18985363 | doi=10.1007/s00401-008-0455-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18985363  }} </ref><ref name="pmid24748374">{{cite journal| author=Arita H, Narita Y, Matsushita Y, Fukushima S, Yoshida A, Takami H et al.| title=Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas. | journal=Brain Tumor Pathol | year= 2015 | volume= 32 | issue= 1 | pages= 22-30 | pmid=24748374 | doi=10.1007/s10014-014-0186-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24748374  }} </ref><ref name="pmid20847279">{{cite journal| author=Setty P, Hammes J, Rothämel T, Vladimirova V, Kramm CM, Pietsch T et al.| title=A pyrosequencing-based assay for the rapid detection of IDH1 mutations in clinical samples. | journal=J Mol Diagn | year= 2010 | volume= 12 | issue= 6 | pages= 750-6 | pmid=20847279 | doi=10.2353/jmoldx.2010.090237 | pmc=2963913 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20847279  }} </ref><ref name="pmid23370430">{{cite journal| author=Pang B, Durso MB, Hamilton RL, Nikiforova MN| title=A novel COLD-PCR/FMCA assay enhances the detection of low-abundance IDH1 mutations in gliomas. | journal=Diagn Mol Pathol | year= 2013 | volume= 22 | issue= 1 | pages= 28-34 | pmid=23370430 | doi=10.1097/PDM.0b013e31826c7ff8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23370430  }} </ref><ref name="pmid20886613">{{cite journal| author=Boisselier B, Marie Y, Labussière M, Ciccarino P, Desestret V, Wang X et al.| title=COLD PCR HRM: a highly sensitive detection method for IDH1 mutations. | journal=Hum Mutat | year= 2010 | volume= 31 | issue= 12 | pages= 1360-5 | pmid=20886613 | doi=10.1002/humu.21365 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20886613  }} </ref>
:*''[[Isocitrate dehydrogenase|IDH1]]''
:*''[[IDH2]]''<ref name="pmid24004584">{{cite journal| author=Pan Y, Qi XL, Wang LM, Dong RF, Zhang M, Zheng DF et al.| title=[Mutation of isocitrate dehydrogenase gene in Chinese patients with glioma]. | journal=Zhonghua Bing Li Xue Za Zhi | year= 2013 | volume= 42 | issue= 5 | pages= 292-8 | pmid=24004584 | doi=10.3760/cma.j.issn.0529-5807.2013.05.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24004584  }} </ref><ref name="pmid19554337">{{cite journal| author=Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A et al.| title=Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. | journal=Acta Neuropathol | year= 2009 | volume= 118 | issue= 4 | pages= 469-74 | pmid=19554337 | doi=10.1007/s00401-009-0561-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19554337  }} </ref><ref name="pmid19765000">{{cite journal| author=Sonoda Y, Kumabe T, Nakamura T, Saito R, Kanamori M, Yamashita Y et al.| title=Analysis of IDH1 and IDH2 mutations in Japanese glioma patients. | journal=Cancer Sci | year= 2009 | volume= 100 | issue= 10 | pages= 1996-8 | pmid=19765000 | doi=10.1111/j.1349-7006.2009.01270.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19765000  }} </ref><ref name="pmid25008158">{{cite journal| author=Arita H, Narita Y, Yoshida A, Hashimoto N, Yoshimine T, Ichimura K| title=IDH1/2 mutation detection in gliomas. | journal=Brain Tumor Pathol | year= 2015 | volume= 32 | issue= 2 | pages= 79-89 | pmid=25008158 | doi=10.1007/s10014-014-0197-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25008158  }} </ref><ref name="pmid20160062">{{cite journal| author=van den Bent MJ, Dubbink HJ, Marie Y, Brandes AA, Taphoorn MJ, Wesseling P et al.| title=IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. | journal=Clin Cancer Res | year= 2010 | volume= 16 | issue= 5 | pages= 1597-604 | pmid=20160062 | doi=10.1158/1078-0432.CCR-09-2902 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20160062  }} </ref><ref name="pmid24889502">{{cite journal| author=Catteau A, Girardi H, Monville F, Poggionovo C, Carpentier S, Frayssinet V et al.| title=A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma. | journal=Acta Neuropathol Commun | year= 2014 | volume= 2 | issue=  | pages= 58 | pmid=24889502 | doi=10.1186/2051-5960-2-58 | pmc=4229941 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24889502  }} </ref>
:*''[[IDH2]]''
:*[[TERT]] [[promoter]]<ref name="pmid26061753">{{cite journal| author=Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H et al.| title=Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. | journal=N Engl J Med | year= 2015 | volume= 372 | issue= 26 | pages= 2499-508 | pmid=26061753 | doi=10.1056/NEJMoa1407279 | pmc=4489704 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26061753  }} </ref><ref name="pmid30346624">{{cite journal| author=Diplas BH, Liu H, Yang R, Hansen LJ, Zachem AL, Zhao F et al.| title=Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas. | journal=Neuro Oncol | year= 2019 | volume= 21 | issue= 4 | pages= 440-450 | pmid=30346624 | doi=10.1093/neuonc/noy167 | pmc=6422442 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30346624  }} </ref><ref name="pmid26617880">{{cite journal| author=Sun ZL, Chan AK, Chen LC, Tang C, Zhang ZY, Ding XJ et al.| title=TERT promoter mutated WHO grades II and III gliomas are located preferentially in the frontal lobe and avoid the midline. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 9 | pages= 11485-94 | pmid=26617880 | doi= | pmc=4637696 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26617880  }} </ref><ref name="pmid26957363">{{cite journal| author=Yang P, Cai J, Yan W, Zhang W, Wang Y, Chen B et al.| title=Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas. | journal=Neuro Oncol | year= 2016 | volume= 18 | issue= 8 | pages= 1099-108 | pmid=26957363 | doi=10.1093/neuonc/now021 | pmc=4933482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26957363  }} </ref><ref name="pmid25314060">{{cite journal| author=Labussière M, Di Stefano AL, Gleize V, Boisselier B, Giry M, Mangesius S et al.| title=TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations. | journal=Br J Cancer | year= 2014 | volume= 111 | issue= 10 | pages= 2024-32 | pmid=25314060 | doi=10.1038/bjc.2014.538 | pmc=4229642 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25314060  }} </ref><ref name="pmid26608520">{{cite journal| author=Nencha U, Rahimian A, Giry M, Sechi A, Mokhtari K, Polivka M et al.| title=TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas. | journal=J Neurooncol | year= 2016 | volume= 126 | issue= 3 | pages= 441-6 | pmid=26608520 | doi=10.1007/s11060-015-1999-3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26608520  }} </ref>
:*''CIC''
:*[[H3F3A|H3]] K27M [[mutations]] in either ''[[H3F3A]]'' (one of two [[genes]] [[Encoding (memory)|encoding]] the [[histone]] H3.3 variant) or ''[[HIST1H3B]]/[[HIST1H3C|C]]'' ([[Encoding (memory)|encoding]] the [[histone]] H3.1 variant).<ref name="pmid22661320">{{cite journal| author=Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E et al.| title=K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. | journal=Acta Neuropathol | year= 2012 | volume= 124 | issue= 3 | pages= 439-47 | pmid=22661320 | doi=10.1007/s00401-012-0998-0 | pmc=3422615 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22661320  }} </ref><ref name="pmid30890717">{{cite journal| author=Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N et al.| title=H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. | journal=Nat Commun | year= 2019 | volume= 10 | issue= 1 | pages= 1262 | pmid=30890717 | doi=10.1038/s41467-019-09140-x | pmc=6425035 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30890717  }} </ref><ref name="pmid22286216">{{cite journal| author=Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J et al.| title=Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. | journal=Nat Genet | year= 2012 | volume= 44 | issue= 3 | pages= 251-3 | pmid=22286216 | doi=10.1038/ng.1102 | pmc=3288377 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22286216  }} </ref><ref name="pmid26399631">{{cite journal| author=Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N et al.| title=Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. | journal=Acta Neuropathol | year= 2015 | volume= 130 | issue= 6 | pages= 815-27 | pmid=26399631 | doi=10.1007/s00401-015-1478-0 | pmc=4654747 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26399631  }} </ref><ref name="pmid27038188">{{cite journal| author=Castel D, Grill J, Debily MA| title=Histone H3 genotyping refines clinico-radiological diagnostic and prognostic criteria in DIPG. | journal=Acta Neuropathol | year= 2016 | volume= 131 | issue= 5 | pages= 795-6 | pmid=27038188 | doi=10.1007/s00401-016-1568-7 | pmc=4835508 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27038188  }} </ref><ref name="pmid28522693">{{cite journal| author=Cordero FJ, Huang Z, Grenier C, He X, Hu G, McLendon RE et al.| title=Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG. | journal=Mol Cancer Res | year= 2017 | volume= 15 | issue= 9 | pages= 1243-1254 | pmid=28522693 | doi=10.1158/1541-7786.MCR-16-0389 | pmc=5581686 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28522693  }} </ref>
:*''[[mutation|NJDS]]'' (A 2009 [[Oxford Forum|Oxford]] Neurosymposium [[Study design|study]] illustrated that there's a 69% [[correlation]] between NJDS [[gene mutation]] and [[tumor]] [[Initiation (chemistry)|initiation]]).
:*''[[CIC (gene)|CIC]]''<ref name="pmid24086756">{{cite journal| author=Eisenreich S, Abou-El-Ardat K, Szafranski K, Campos Valenzuela JA, Rump A, Nigro JM et al.| title=Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing. | journal=PLoS One | year= 2013 | volume= 8 | issue= 9 | pages= e76623 | pmid=24086756 | doi=10.1371/journal.pone.0076623 | pmc=3785522 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24086756  }} </ref><ref name="pmid22072542">{{cite journal| author=Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J et al.| title=Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. | journal=J Pathol | year= 2012 | volume= 226 | issue= 1 | pages= 7-16 | pmid=22072542 | doi=10.1002/path.2995 | pmc=3246739 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22072542  }} </ref>
:*''[[Far upstream element-binding protein 1|FUBP1]]''
:*''[[Far upstream element-binding protein 1|FUBP1]]''
:*''[[p53]]''
:*''[[TP53]]''
:*''[[p53]]''<ref name="pmid24590827">{{cite journal| author=Gillet E, Alentorn A, Doukouré B, Mundwiller E, van Thuijl HF, van Thuij H et al.| title=TP53 and p53 statuses and their clinical impact in diffuse low grade gliomas. | journal=J Neurooncol | year= 2014 | volume= 118 | issue= 1 | pages= 131-9 | pmid=24590827 | doi=10.1007/s11060-014-1407-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24590827  }} </ref>
:*[[BRAF]] alterations:<ref name="pmid25720745">{{cite journal| author=Rodriguez FJ, Schniederjan MJ, Nicolaides T, Tihan T, Burger PC, Perry A| title=High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 4 | pages= 609-610 | pmid=25720745 | doi=10.1007/s00401-015-1400-9 | pmc=4696044 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25720745  }} </ref>
:**''[[KIAA1549L (gene)|KIAA1549]]''-''[[BRAF (gene)|BRAF]]'' [[Fusion gene|fusion]]
:**''[[BRAF]]'' V600E [[mutation]]
:*''[[CD57|Leu-7]]''
:*''[[CD57|Leu-7]]''
:*''[[TCF12|TCF-12]]''
:*''[[TCF12|TCF-12]]''
Line 26: Line 34:
:*''[[EGFR]]''
:*''[[EGFR]]''
:*''[[PTEN]]''
:*''[[PTEN]]''
*There is a strong association of oligodendroglioma with expression of receptor tyrosine kinases that activate PI3K/AKT, RAS/MAP, and PLC/PKC pathways.<ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>
*There is a [[strong]] [[Association (statistics)|association]] of [[oligodendroglioma]] with [[expression]] of [[receptor tyrosine kinases]] that activate [[Phosphoinositide 3-kinase|PI3K]]/[[AKT]], [[RAS]]/[[MAP]], and [[PLC]]/[[PKC alpha|PKC]] pathways.<ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>


===Gross Pathology===
===Gross Pathology===
*On gross pathology, oligodendroglioma is characterized by a well-circumscribed, gelatinous, gray mass which may expand a [[gyrus]] and remodel the [[skull]].<ref name=grosspa>Gross appearance of oligodendroglioma. Dr Henry Knipe and Dr Frank Gaillard et al. http://radiopaedia.org/articles/oligodendroglioma</ref>
*On [[gross pathology]], [[oligodendroglioma]] is characterized by a well-circumscribed, [[Gelatinase|gelatinous]], [[gray]] [[mass]] which may [[Expanded access|expand]] a [[gyrus]] and remodel the [[skull|skul.l]]<ref name="grosspa">Gross appearance of oligodendroglioma. Dr Henry Knipe and Dr Frank Gaillard et al. http://radiopaedia.org/articles/oligodendroglioma</ref>
*Other characteristic gross pathological features associated with oligodendroglioma include:<ref name=grosspa>Gross appearance of oligodendroglioma. Dr Henry Knipe and Dr Frank Gaillard et al. http://radiopaedia.org/articles/oligodendroglioma</ref><ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>
*Other [[Characteristic function (probability theory)|characteristic]] [[Gross pathology|gross pathological]] [[Features (pattern recognition)|features]] [[Association (statistics)|associated]] with [[oligodendroglioma]] include:<ref name="grosspa">Gross appearance of oligodendroglioma. Dr Henry Knipe and Dr Frank Gaillard et al. http://radiopaedia.org/articles/oligodendroglioma</ref><ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>
 
**[[Calcification]] (70-90%; one of the most [[Frequentism|frequently]] [[Calcification|calcifying]] [[tumors]])
:*[[Calcification]] (70-90%; one of the most frequently calcifying tumors)
**[[Hemorrhage|Focal hemorrhage]]
:*[[Hemorrhage|Focal hemorrhage]]
**[[cyst|Cystic]] (20%)
:*[[cyst|Cystic]] (20%)
*Common intracranial sites [[Association (statistics)|associated]] with [[oligodendroglioma]] include:<ref name="gross">Gross/radiologic findings of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
*Common intracranial sites associated with oligodendroglioma include:<ref name=gross>Gross/radiologic findings of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
**[[Cerebral hemisphere]]s ([[cortex]] and [[white matter]]) - [[Distribution (pharmacology)|distribution]] between [[frontal lobe|frontal]] (most common, > 50% of cases), [[parietal lobe|parietal]], [[temporal lobe|temporal]], and [[occipital lobe]] approximates 3:2:2:1.
:*[[Cerebral hemisphere]]s - distribution between [[frontal lobe|frontal]], [[parietal lobe|parietal]], [[temporal lobe|temporal]], and [[occipital lobe]] approximates 3:2:2:1
**[[Posterior fossa]] ([[rare]])
:*[[Posterior fossa]] (rare)
**[[spinal cord|Intramedullary spinal cord]] (very [[rare]], only 1.5% of [[oligodendrogliomas]]).
:*[[spinal cord|Intramedullary spinal cord]] (very rare)
{|
|
[[File:Oligogross.jpg|thumb|250px|none| Oligodendroglioma involving frontal lobe [http://peir.path.uab.edu/library/picture.php?/18102]]]
|
[[File:Mixedoligo.jpg|thumb|250px|none| Mixed astrocytoma and oligodendroglioma [http://peir.path.uab.edu/library/picture.php?/18103/categories]]]
|
[[File:Oliggross.jpg|thumb|250px|none| Oligodendroglioma gross appearance [http://peir.path.uab.edu/library/picture.php?/18104/categories]]]
|}


===Microscopic Pathology===
===Microscopic Pathology===
On microscopic histopathological analysis, oligodendroglioma is characterized by:<ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>
On [[microscopic]] [[histopathological]] [[analysis]], [[oligodendroglioma]] is characterized by:<ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref><ref name="micro">Microscopic features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref><ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref><ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref><ref name="pmid22941225">{{cite journal| author=Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D et al.| title=Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. | journal=Acta Neuropathol | year= 2012 | volume= 124 | issue= 5 | pages= 627-41 | pmid=22941225 | doi=10.1007/s00401-012-1037-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22941225 }} </ref>
<ref name=micro>Microscopic features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref><ref name=turk>{{Citation |last=Tihan |first=Tarik|last=Ersen|first=Ayca |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref><ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821  }} </ref>
*[[Diffuse|Diffusely]] [[Growth|growing]], [[Infiltration (medical)|infiltrative]] [[tumor]]
*Diffusely growing tumor
*Moderate [[Cellular|cellularity]]
*Highly cellular lesion composed of cells resembling ''fried eggs'' with:
*Highly [[cellular]] [[lesion]] composed of [[Typical set|typically]] monomorphic [[Cells (biology)|cells]] resembling ''fried [[Egg (biology)|eggs]]'' with:
**[[nucleus|Round nucleus]] - key feature
**[[nucleus|Round nucleus]] - key [[Features (pattern recognition)|feature]]
**Distinct cell borders
**[[Distinctive feature|Distinct]] [[Cell (biology)|cell]] borders
**Moderate-to-marked [[atypia|nuclear atypia]] with speckled "''salt-and-pepper''" chromatin pattern
**Moderate-to-marked [[atypia|nuclear atypia]] with [[Speckle pattern|speckled]] "''[[salt]]-and-[[Pepper spray|pepper]]''" [[chromatin]] [[pattern]]
**[[cytoplasm|Clear cytoplasm]]
**Inconspicuous [[nucleoli]]
***Some oligodendrogliomas have [[eosinophilic]] cytoplasm with focal perinuclear clearing
**[[cytoplasm|Clear cytoplasm]] (artifactual [[retraction]] of the [[cytoplasm]] on routinely [[Process (anatomy)|processed]] [[formalin]] [[Fixed effects|fixed]], [[paraffin]] [[Embedded value|embedded]] [[Materials science|material]], [[Leading strand|leading]] to the [[Characteristic function (probability theory)|characteristic]] "fried [[Egg (biology)|egg]]" [[appearance]]).
**Acutely branched capillary sized vessels - "''chicken-wire''" like appearance
***Some [[oligodendrogliomas]] have [[eosinophilic]] [[cytoplasm]] with focal [[Perinuclear space|perinuclear]] clearing.
***Abundant, delicate appearing; may vaguely resemble a [[paraganglioma]] at low power
**[[Dense]] [[Network motif|network]] of [[Acute|acutely]] fine branched [[capillary]] [[Size consistency|sized]] [[vessels]] -classically [[Reference|referred]] to as a "''chicken-wire''" like [[appearance]]/[[pattern|pattern.]]<ref name="microscope">Images of microscopic appearance of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma</ref>
*[[Calcification]]s - striking feature
***Abundant and delicate [[Appearance|appearing]]; may [[Vagueness|vaguely]] resemble a [[paraganglioma]] at low [[Power nap|power]].
*Perifocal [[edema]] - rare
*Small punctate [[calcification]]s, particularly along the [[blood vessels]] is a striking [[Features (pattern recognition)|feature]] (but not a [[Specific activity|specific]] finding).
*Few tumors may exhibit [[eosinophilic]] granular bodies
*Perifocal [[edema]] - [[rare]]
*Some tumors may show a spongioblastoma-like growth pattern
*[[Fewmets|Few]] [[tumors]] may [[Exhibitionism|exhibit]] [[eosinophilic]] [[Granular cell|granular]] [[Body|bodies]]
 
*Some [[tumors]] may show a [[spongioblastoma]]-like [[growth]] [[pattern]]
On microscopic histopathological analysis, [[anaplastic|anaplastic oligodendroglioma]] is characterized by:<ref name=micro>Microscopic features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
*[[Tumor cell|Tumor cells]] may form following [[Secondary structure|secondary structures]] in the surrounding [[Infiltration (medical)|infiltrated]] [[brain]] [[parenchyma]]:
*Focal or diffusely increased cell density
**Perineuronal satellitosis
*Atypical to frankly [[pleomorphic]] cells or [[multinucleated giant cells]]
**[[Subpial space|Subpial]] accumulation
*Tumor cells may be plasmacytoid (i.e. have a [[plasma cell]]-like appearance)
**[[Perivascular cell|Perivascular]] [[Distribution (pharmacology)|distribution]] (less common)
*Microgemistocytic [[appearance]] of [[Tumor cell|tumor cells]] with a rounded [[belly]] of [[Eccentricity (mathematics)|eccentric]] [[Glial fibrillary acidic protein|GFAP]]+ [[eosinophilic]] [[cytoplasm]] (maybe present).<ref name="pmid2205356">{{cite journal| author=Kros JM, Van Eden CG, Stefanko SZ, Waayer-Van Batenburg M, van der Kwast TH| title=Prognostic implications of glial fibrillary acidic protein containing cell types in oligodendrogliomas. | journal=Cancer | year= 1990 | volume= 66 | issue= 6 | pages= 1204-12 | pmid=2205356 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2205356  }} </ref>
*A predominant [[Fibrillarin|fibrillar]] [[astrocytic]] [[phenotype]] is compatible with the [[diagnosis]] when following [[Appropriate Use Criteria|appropriate]] [[molecular]] findings are present:<ref name="pmid26061751">{{cite journal| author=Cancer Genome Atlas Research Network. Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR et al.| title=Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. | journal=N Engl J Med | year= 2015 | volume= 372 | issue= 26 | pages= 2481-98 | pmid=26061751 | doi=10.1056/NEJMoa1402121 | pmc=4530011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26061751  }} </ref>
**''[[IDH1|IDH]]'' [[mutation]]
**[[1p36 deletion syndrome|1p]]/19q codeletion
{|
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[[File:Olighe.jpg|thumb|250px|none| Oligodendroglioma HE stain [https://commons.wikimedia.org/wiki/Category:Histopathology_of_oligodendroglioma#/media/File:Image_NP_T4a1_0004.JPG]]]
|
[[File:1200px-Oligodendroglioma discrete invasion HE.jpg|thumb|250px|none|Low power magnification of a Oligodendroglioma biopsy specimen showing discrete infiltration of the surrounding brain [https://librepathology.org/wiki/File:Oligodendroglioma_discrete_invasion_HE.jpg]]]
|
[[File:Oligo hee.jpg|thumb|250px|none| Oligodendroglioma HE stain [https://commons.wikimedia.org/wiki/Category:Histopathology_of_oligodendroglioma#/media/File:Image_NP_T4a1_0002.JPG]]]
|
[[File:Oligo hne.jpg|thumb|250px|none| Oligodendroglioma HE stain [https://commons.wikimedia.org/wiki/Category:Histopathology_of_oligodendroglioma#/media/File:Image_NP_T4a1_0001.JPG]]]
|
|}
{|
|
[[File:Oligohe.jpg|thumb|250px|none| Oligodendroglioma HE stain [https://commons.wikimedia.org/wiki/Category:Histopathology_of_oligodendroglioma#/media/File:Image_NP_T4a1_0003.JPG]]]
|
[[File:Oligodendorglioma GFAP.jpg|thumb|250px|none| GFAP immunohistochemistry in a histopathology specimen of oligodendroglioma grade II WHO [https://commons.wikimedia.org/wiki/Category:Histopathology_of_oligodendroglioma#/media/File:Oligodendorglioma_GFAP.jpg]]]
|
[[File:Oligodendroglioma histo.jpg|thumb|250px|none| High magnification micrograph of an oligodendroglioma showing the characteristic branching, small, chicken wire-like blood vessels and fried egg-like cells, with clear cytoplasm and well-defined cell borders. H&E stain. [https://commons.wikimedia.org/wiki/File:Oligodendroglioma1_high_mag.jpg]]]
|
[[File:Oligo low mag.jpg|thumb|250px|none|Low magnification micrograph of an oligodendroglioma showing the characteristic, small, branching, chicken wire-like blood vessels. H&E stain. [https://commons.wikimedia.org/wiki/File:Oligodendroglioma1_low_mag.jpg]]]
|
|}
====Microscopic histopathological findings in anaplastic oligodendroglioma====
On [[microscopic]] [[histopathological]] [[analysis]], [[anaplastic|anaplastic oligodendroglioma]], ''[[IDH1|IDH]]'' [[mutant]] and [[1p36 deletion syndrome|1p]]/19q codeleted, is characterized by:<ref name="micro">Microscopic features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
*Focal or [[Diffuse|diffusely]] increased [[cell]] [[density]]
*Atypical to [[Frank Newhook|frankly]] [[pleomorphic]] [[Cells (biology)|cells]] or [[multinucleated giant cells]]
*[[Tumor cell|Tumor cells]] may be [[plasmacytoid]] (i.e. have a [[plasma cell]]-like [[appearance]])
**Also called as [[astrocyte|minigemistocytes]]
**Also called as [[astrocyte|minigemistocytes]]
*Significant or brisk [[mitoses|mitotic activity]] (>= 6 mitoses per 10 [[Medical Abbreviations|HPF]])
*[[Significant figure|Significant]]/brisk infrequent [[mitoses|mitotic activity]] (6 [[mitoses]] per 10 [[Medical Abbreviations|HPF]])<ref name="LP">Images of oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref><ref name="pmid16794749">{{cite journal| author=Smith SF, Simpson JM, Brewer JA, Sekhon LH, Biggs MT, Cook RJ et al.| title=The presence of necrosis and/or microvascular proliferation does not influence survival of patients with anaplastic oligodendroglial tumours: review of 98 patients. | journal=J Neurooncol | year= 2006 | volume= 80 | issue= 1 | pages= 75-82 | pmid=16794749 | doi=10.1007/s11060-006-9158-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16794749  }} </ref>
*[[Necrosis]]
*[[Rare]] foci of:
***Numerous [[apoptosis|apoptotic cells]]
**[[Necrosis]]
*[[vascular|Microvacular proliferation]]
**[[apoptosis|Apoptotic cells]]
**Either in the form of 'glomeruloid' vessels or endothelial hyperplasia
**[[vascular|Microvacular proliferation]] either in the form of:
***[[Glomerular|Glomeruloid]]' [[vessels]] or
***[[Endothelial]] [[hyperplasia]]
{|
|
[[File:Brisk mitotic rate.jpg|thumb|250px|none|Brisk mitotic rate in anaplastic oligodendroglioma [http://www.pathologyoutlines.com/topic/cnstumoranaplasticoligodendroglioma.html]]]
|
[[File:Vascularproliferationoligo.jpg|thumb|250px|none| Vascularproliferation [https://emedicine.medscape.com/article/1743896-overview Source: Roger E McLendon, MD et al.]]]
|
[[File:1200px-MAP2 anaplastic oligodendroglioma.jpg|thumb|250px|none|Histopathology of anaplastic oligodendroglioma (MAP2 staining) showing perinuclear immunoreactivity of tumor cells[https://librepathology.org/wiki/File:MAP2_anaplastic_oligodendroglioma.jpg]]]
|
[[File:Fried egg app.jpg|thumb|250px|none| "Fried egg" appearance [http://www.pathologyoutlines.com/topic/cnstumoroligodendrogliomaidhmutant.html Source: John DeWitt, M.D., Ph.D.]]]
|
|}
{|
|
[[File:Chickenwire vessels.jpg|thumb|250px|none| Chicken wire vessels [http://www.pathologyoutlines.com/topic/cnstumoroligodendrogliomaidhmutant.html Source: John DeWitt, M.D., Ph.D.]]]
|
[[File:Friedeggoligo.jpg|thumb|250px|none| "Fried egg" appearance [http://www.pathologyoutlines.com/topic/cnstumoroligodendrogliomaidhmutant.html Source: John DeWitt, M.D., Ph.D.]]]
|
[[File:Infilcortex.jpg|thumb|250px|none| Infiltrating cortex [http://www.pathologyoutlines.com/topic/cnstumoroligodendrogliomaidhmutant.html Source: John DeWitt, M.D., Ph.D.]]]
|
[[File:1200px-Anaplastic oligodendroglioma minigemistocytes.jpg|thumb|250px|none|Histopathology of anaplastic oligodendroglioma (HE stain) showing minigemistocytes and mitoses among tumor cells with perinuclear halo.[https://librepathology.org/wiki/File:Anaplastic_oligodendroglioma_minigemistocytes.jpg]]]
|
[[File:1200px-IDH1 R132H in anaplastic ologodendroglioma.jpg|thumb|250px|none| Histopathology of anaplastic oligodendroglioma (IDH1 R132H staining) showing immunoreactivity of tumor cells idicating presence of the isocitrate dehydrogenase 1 R132H mutation [https://librepathology.org/wiki/File:IDH1_R132H_in_anaplastic_ologodendroglioma.jpg]]]
|
|}


===Immunohistochemistry===
===Immunohistochemistry===
Oligodendroglioma is demonstrated by positivity to tumor markers such as:<ref name=IHC>IHC of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref><ref name="pmid16622556">{{cite journal| author=Hilbig A, Barbosa-Coutinho LM, Netto GC, Bleil CB, Toscani NV| title=[Immunohistochemistry in oligodendrogliomas]. | journal=Arq Neuropsiquiatr | year= 2006 | volume= 64 | issue= 1 | pages= 67-71 | pmid=16622556 | doi=/S0004-282X2006000100014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16622556  }} </ref><ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref>
[[Oligodendroglioma]] is demonstrated by [[Positivity effect|positivity]] to [[tumor markers]] such as:<ref name="IHC">IHC of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref><ref name="pmid16622556">{{cite journal| author=Hilbig A, Barbosa-Coutinho LM, Netto GC, Bleil CB, Toscani NV| title=[Immunohistochemistry in oligodendrogliomas]. | journal=Arq Neuropsiquiatr | year= 2006 | volume= 64 | issue= 1 | pages= 67-71 | pmid=16622556 | doi=/S0004-282X2006000100014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16622556  }} </ref><ref name="von DeimlingHartmann2005">{{cite journal|last1=von Deimling|first1=A|last2=Hartmann|first2=C|title=Oligodendrogliomas: Impact of molecular genetics on treatment|journal=Neurology India|volume=53|issue=2|year=2005|pages=140|issn=0028-3886|doi=10.4103/0028-3886.16394}}</ref><ref name="pmid26671986">{{cite journal| author=Tanboon J, Williams EA, Louis DN| title=The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas. | journal=J Neuropathol Exp Neurol | year= 2016 | volume= 75 | issue= 1 | pages= 4-18 | pmid=26671986 | doi=10.1093/jnen/nlv009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26671986  }} </ref>
 
*[[isocitrate dehydrogenase|IDH1-R132H]] (majority of cases)<ref name="pmid25324168">{{cite journal| author=Kato Y| title=Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas. | journal=Brain Tumor Pathol | year= 2015 | volume= 32 | issue= 1 | pages= 3-11 | pmid=25324168 | doi=10.1007/s10014-014-0202-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25324168  }} </ref>
*[[Microtubule-associated protein|MAP2]]
*[[Microtubule-associated protein|MAP2]]
*[[GFAP]]
*[[GFAP]] (positive in intermingled [[Reactivity|reactive]] [[astrocytes]] and minigemistocytes)
*[[SOX10]]
*[[S100 calcium binding protein A8|S-100]]
*[[S100 calcium binding protein A8|S-100]]
*EMA
*EMA
*[[isocitrate dehydrogenase|IDH1-R132H]]
*[[ATRX]]
*ATRX
*[[Ki-67 (Biology)|Ki-67]]
*[[Ki-67 (Biology)|Ki-67]]
*[[Neuron-Specific Enolase (NSE)|NSE]]  
*[[Neuron-Specific Enolase (NSE)|NSE]]  
Line 82: Line 154:
*[[OLIG1]]
*[[OLIG1]]
*[[OLIG2]]
*[[OLIG2]]
 
[[Oligodendroglioma]] [[Stain|stains]] negative for:
===Gallery===
*[[p53]] ([[rare]] weakly positive [[Cells (biology)|cells]] can be seen)
<gallery>
*[[Keratins]] (although cocktails may show [[Cross-correlation|cross]] [[reactivity]])
Image:Oligodendroglioma1 low mag.jpg|Oligodendroglioma low magnification showing the characteristic small, branching, ''chicken wire''-like blood vessels.H&E stain.<ref name=microscope>Images of microscopic appearance of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma</ref>
Image:Oligodendroglioma1 high mag.jpg|Oligodendroglioma high magnification showing highly cellular lesion composed of cells resembling ''fried eggs'' with distinct cell borders moderate-to-marked nuclear atypia, and a clear cytoplasm. Acutely branched capillary sized vessels - "''chicken-wire''" like appearance.<ref name=microscope>Images of microscopic appearance of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma</ref>
Image:Oligodendroglioma discrete invasion HE.jpg|Low power magnification of oligodendroglioma biopsy specimen showing discrete infiltration of the surrounding brain (HE stain, x40 mag).<ref name=LP>Images of oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
Image:Anaplastic oligodendroglioma minigemistocytes.jpg|Histopathology of anaplastic oligodendroglioma showing minigemistocytes and mitoses among tumor cells with perinuclear halo. HE stain.<ref name=LP>Images of oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
Image:MAP2 anaplastic oligodendroglioma.jpg|Histopathology of anaplastic oligodendroglioma (MAP2 staining) showing perinuclear immunoreactivity of tumor cells.<ref name=LP>Images of oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
Image:IDH1 R132H in anaplastic ologodendroglioma.jpg|Histopathology of anaplastic oligodendroglioma (IDH1-R132H staining) showing immunoreactivity of tumor cells indicating presence of the isocitrate dehydrogenase 1-R132H mutation.<ref name=LP>Images of oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma</ref>
</gallery>


==References==
==References==
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Latest revision as of 13:31, 13 August 2019

Oligodendroglioma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [16]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[17]Sujit Routray, M.D. [18]

Overview

Oligodendroglioma arises from the tripotential glial precursor cells and not from the bipotential oligodendrocytes. Genes associated with the pathogenesis of oligodendroglioma include t[1;19][q10;p10], ATRX, NJDS, IDH1, IDH2, TERT promoter, H3 K27M (H3F3A, HIST1H3B/C), CIC, FUBP1, p53, Leu-7, TCF-12, TP53,MGMT, TP73, BRAF, EGFR, and PTEN. Common intracranial sites involved by oligodendroglioma include cerebral hemispheres, posterior fossa, and intramedullary spinal cord. On gross pathology, oligodendroglioma is characterized by a well-circumscribed, gelatinous, calcified, cystic, gray mass with focal hemorrhage which may expand a gyrus and remodel the skull. On microscopic histopathological analysis, oligodendroglioma is characterized by diffuse growthpattern of highly cellular lesion of monomorphic cells having rounded nucleus with atypia, speckled "salt-and-pepper" chromatin pattern and perinuclear haloresembling fried eggs, distinct cell borders, clear cytoplasm, abundant calcification and "chicken-wire" like vascularity pattern. Oligodendroglioma is demonstrated by positivity to tumor markers such as IDH1-R132H, MAP2, GFAP, S-100, SOX10, EMA, ATRX, Ki-67, NSE, synaptophysin, OLIG1, and OLIG2.

Pathophysiology

Pathogenesis

Genetics

Gross Pathology

Oligodendroglioma involving frontal lobe [1]
Mixed astrocytoma and oligodendroglioma [2]
Oligodendroglioma gross appearance [3]

Microscopic Pathology

On microscopic histopathological analysis, oligodendroglioma is characterized by:[20][60][61][62][63]

Oligodendroglioma HE stain [4]
Low power magnification of a Oligodendroglioma biopsy specimen showing discrete infiltration of the surrounding brain [5]
Oligodendroglioma HE stain [6]
Oligodendroglioma HE stain [7]
Oligodendroglioma HE stain [8]
GFAP immunohistochemistry in a histopathology specimen of oligodendroglioma grade II WHO [9]
High magnification micrograph of an oligodendroglioma showing the characteristic branching, small, chicken wire-like blood vessels and fried egg-like cells, with clear cytoplasm and well-defined cell borders. H&E stain. [10]
Low magnification micrograph of an oligodendroglioma showing the characteristic, small, branching, chicken wire-like blood vessels. H&E stain. [11]

Microscopic histopathological findings in anaplastic oligodendroglioma

On microscopic histopathological analysis, anaplastic oligodendroglioma, IDH mutant and 1p/19q codeleted, is characterized by:[60]

Brisk mitotic rate in anaplastic oligodendroglioma [12]
Vascularproliferation Source: Roger E McLendon, MD et al.
Histopathology of anaplastic oligodendroglioma (MAP2 staining) showing perinuclear immunoreactivity of tumor cells[13]
"Fried egg" appearance Source: John DeWitt, M.D., Ph.D.
Chicken wire vessels Source: John DeWitt, M.D., Ph.D.
"Fried egg" appearance Source: John DeWitt, M.D., Ph.D.
Infiltrating cortex Source: John DeWitt, M.D., Ph.D.
Histopathology of anaplastic oligodendroglioma (HE stain) showing minigemistocytes and mitoses among tumor cells with perinuclear halo.[14]
Histopathology of anaplastic oligodendroglioma (IDH1 R132H staining) showing immunoreactivity of tumor cells idicating presence of the isocitrate dehydrogenase 1 R132H mutation [15]

Immunohistochemistry

Oligodendroglioma is demonstrated by positivity to tumor markers such as:[68][69][20][7]

Oligodendroglioma stains negative for:

References

  1. General features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma#cite_note-1
  2. Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y; et al. (2015). "Mutational landscape and clonal architecture in grade II and III gliomas". Nat Genet. 47 (5): 458–68. doi:10.1038/ng.3273. PMID 25848751.
  3. Leeper HE, Caron AA, Decker PA, Jenkins RB, Lachance DH, Giannini C (2015). "IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas". Oncotarget. 6 (30): 30295–305. doi:10.18632/oncotarget.4497. PMC 4745799. PMID 26210286.
  4. Sabha N, Knobbe CB, Maganti M, Al Omar S, Bernstein M, Cairns R; et al. (2014). "Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas". Neuro Oncol. 16 (7): 914–23. doi:10.1093/neuonc/not299. PMC 4057130. PMID 24470545.
  5. Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B; et al. (2013). "Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas". Nat Genet. 45 (6): 602–12. doi:10.1038/ng.2611. PMC 3727232. PMID 23583981.
  6. Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y; et al. (2014). "The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma". Nat Genet. 46 (5): 444–450. doi:10.1038/ng.2938. PMC 4056452. PMID 24705251.
  7. 7.0 7.1 Tanboon J, Williams EA, Louis DN (2016). "The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas". J Neuropathol Exp Neurol. 75 (1): 4–18. doi:10.1093/jnen/nlv009. PMID 26671986.
  8. Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF; et al. (2012). "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas". Oncotarget. 3 (7): 709–22. doi:10.18632/oncotarget.588. PMC 3443254. PMID 22869205.
  9. Sahm F, Koelsche C, Meyer J, Pusch S, Lindenberg K, Mueller W; et al. (2012). "CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas". Acta Neuropathol. 123 (6): 853–60. doi:10.1007/s00401-012-0993-5. PMID 22588899.
  10. 10.0 10.1 Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M (2005). "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene". Clin Cancer Res. 11 (3): 1119–28. PMID 15709179.
  11. Frenel JS, Leux C, Loussouarn D, Le Loupp AG, Leclair F, Aumont M; et al. (2013). "Combining two biomarkers, IDH1/2 mutations and 1p/19q codeletion, to stratify anaplastic oligodendroglioma in three groups: a single-center experience". J Neurooncol. 114 (1): 85–91. doi:10.1007/s11060-013-1152-0. PMID 23681562.
  12. Hacisalihoglu P, Kucukodaci Z, Gundogdu G, Bilgic B (2017). "The Correlation Between 1p/19q Codeletion, IDH1 Mutation, p53 Overexpression and Their Prognostic Roles in 41 Turkish Anaplastic Oligodendroglioma Patients". Turk Neurosurg. 27 (5): 682–689. doi:10.5137/1019-5149.JTN.16832-15.1. PMID 27651340.
  13. Molecular genetics of oligodendroglioma. https://en.wikipedia.org/wiki/Oligodendroglioma
  14. Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH; et al. (2011). "Mutations in CIC and FUBP1 contribute to human oligodendroglioma". Science. 333 (6048): 1453–5. doi:10.1126/science.1210557. PMC 3170506. PMID 21817013.
  15. Prognosis and treatment of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma
  16. 16.0 16.1 Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J; et al. (2012). "Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers". J Pathol. 226 (1): 7–16. doi:10.1002/path.2995. PMC 3246739. PMID 22072542.
  17. Labreche K, Simeonova I, Kamoun A, Gleize V, Chubb D, Letouzé E; et al. (2015). "TCF12 is mutated in anaplastic oligodendroglioma". Nat Commun. 6: 7207. doi:10.1038/ncomms8207. PMC 4490400. PMID 26068201.
  18. Suri V, Jha P, Agarwal S, Pathak P, Sharma MC, Sharma V; et al. (2011). "Molecular profile of oligodendrogliomas in young patients". Neuro Oncol. 13 (10): 1099–106. doi:10.1093/neuonc/nor146. PMC 3177666. PMID 21937591.
  19. Hagel C, Laking G, Laas R, Scheil S, Jung R, Milde-Langosch K; et al. (1996). "Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas". Eur J Cancer. 32A (13): 2242–8. PMID 9038605.
  20. 20.0 20.1 20.2 20.3 20.4 von Deimling, A; Hartmann, C (2005). "Oligodendrogliomas: Impact of molecular genetics on treatment". Neurology India. 53 (2): 140. doi:10.4103/0028-3886.16394. ISSN 0028-3886.
  21. 21.0 21.1 Cancer Genome Atlas Research Network. Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR; et al. (2015). "Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas". N Engl J Med. 372 (26): 2481–98. doi:10.1056/NEJMoa1402121. PMC 4530011. PMID 26061751.
  22. 22.0 22.1 Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H; et al. (2015). "Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors". N Engl J Med. 372 (26): 2499–508. doi:10.1056/NEJMoa1407279. PMC 4489704. PMID 26061753.
  23. Ueki K, Nishikawa R, Nakazato Y, Hirose T, Hirato J, Funada N; et al. (2002). "Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors". Clin Cancer Res. 8 (1): 196–201. PMID 11801559.
  24. Labussière M, Boisselier B, Mokhtari K, Di Stefano AL, Rahimian A, Rossetto M; et al. (2014). "Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes". Neurology. 83 (13): 1200–6. doi:10.1212/WNL.0000000000000814. PMID 25150284.
  25. Nambirajan A, Suri V, Kedia S, Goyal K, Malgulwar PB, Khanna G; et al. (2018). "Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harbouring chromosome 1p/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications". Brain Tumor Pathol. 35 (3): 186–191. doi:10.1007/s10014-018-0325-0. PMID 30030640.
  26. McDonald JM, See SJ, Tremont IW, Colman H, Gilbert MR, Groves M; et al. (2005). "The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors". Cancer. 104 (7): 1468–77. doi:10.1002/cncr.21338. PMID 16088966.
  27. Reifenberger J, Reifenberger G, Liu L, James CD, Wechsler W, Collins VP (1994). "Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p". Am J Pathol. 145 (5): 1175–90. PMC 1887413. PMID 7977648.
  28. Reuss DE, Sahm F, Schrimpf D, Wiestler B, Capper D, Koelsche C; et al. (2015). "ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma". Acta Neuropathol. 129 (1): 133–46. doi:10.1007/s00401-014-1370-3. PMID 25427834.
  29. Chen N, Yu T, Gong J, Nie L, Chen X, Zhang M; et al. (2016). "IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients". Pathology. 48 (7): 675–683. doi:10.1016/j.pathol.2016.07.010. PMID 27780605.
  30. Zhou YX, Wang JX, Feng M, Sun CM, Sun T, Chen GL; et al. (2012). "Analysis of isocitrate dehydrogenase 1 mutation in 97 patients with glioma". J Mol Neurosci. 47 (3): 442–7. doi:10.1007/s12031-011-9681-5. PMID 22113362.
  31. Capper D, Weissert S, Balss J, Habel A, Meyer J, Jäger D; et al. (2010). "Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors". Brain Pathol. 20 (1): 245–54. doi:10.1111/j.1750-3639.2009.00352.x. PMID 19903171.
  32. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W; et al. (2009). "IDH1 and IDH2 mutations in gliomas". N Engl J Med. 360 (8): 765–73. doi:10.1056/NEJMoa0808710. PMC 2820383. PMID 19228619.
  33. Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A (2008). "Analysis of the IDH1 codon 132 mutation in brain tumors". Acta Neuropathol. 116 (6): 597–602. doi:10.1007/s00401-008-0455-2. PMID 18985363.
  34. Arita H, Narita Y, Matsushita Y, Fukushima S, Yoshida A, Takami H; et al. (2015). "Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas". Brain Tumor Pathol. 32 (1): 22–30. doi:10.1007/s10014-014-0186-0. PMID 24748374.
  35. Setty P, Hammes J, Rothämel T, Vladimirova V, Kramm CM, Pietsch T; et al. (2010). "A pyrosequencing-based assay for the rapid detection of IDH1 mutations in clinical samples". J Mol Diagn. 12 (6): 750–6. doi:10.2353/jmoldx.2010.090237. PMC 2963913. PMID 20847279.
  36. Pang B, Durso MB, Hamilton RL, Nikiforova MN (2013). "A novel COLD-PCR/FMCA assay enhances the detection of low-abundance IDH1 mutations in gliomas". Diagn Mol Pathol. 22 (1): 28–34. doi:10.1097/PDM.0b013e31826c7ff8. PMID 23370430.
  37. Boisselier B, Marie Y, Labussière M, Ciccarino P, Desestret V, Wang X; et al. (2010). "COLD PCR HRM: a highly sensitive detection method for IDH1 mutations". Hum Mutat. 31 (12): 1360–5. doi:10.1002/humu.21365. PMID 20886613.
  38. Pan Y, Qi XL, Wang LM, Dong RF, Zhang M, Zheng DF; et al. (2013). "[Mutation of isocitrate dehydrogenase gene in Chinese patients with glioma]". Zhonghua Bing Li Xue Za Zhi. 42 (5): 292–8. doi:10.3760/cma.j.issn.0529-5807.2013.05.002. PMID 24004584.
  39. Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A; et al. (2009). "Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas". Acta Neuropathol. 118 (4): 469–74. doi:10.1007/s00401-009-0561-9. PMID 19554337.
  40. Sonoda Y, Kumabe T, Nakamura T, Saito R, Kanamori M, Yamashita Y; et al. (2009). "Analysis of IDH1 and IDH2 mutations in Japanese glioma patients". Cancer Sci. 100 (10): 1996–8. doi:10.1111/j.1349-7006.2009.01270.x. PMID 19765000.
  41. Arita H, Narita Y, Yoshida A, Hashimoto N, Yoshimine T, Ichimura K (2015). "IDH1/2 mutation detection in gliomas". Brain Tumor Pathol. 32 (2): 79–89. doi:10.1007/s10014-014-0197-x. PMID 25008158.
  42. van den Bent MJ, Dubbink HJ, Marie Y, Brandes AA, Taphoorn MJ, Wesseling P; et al. (2010). "IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group". Clin Cancer Res. 16 (5): 1597–604. doi:10.1158/1078-0432.CCR-09-2902. PMID 20160062.
  43. Catteau A, Girardi H, Monville F, Poggionovo C, Carpentier S, Frayssinet V; et al. (2014). "A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma". Acta Neuropathol Commun. 2: 58. doi:10.1186/2051-5960-2-58. PMC 4229941. PMID 24889502.
  44. Diplas BH, Liu H, Yang R, Hansen LJ, Zachem AL, Zhao F; et al. (2019). "Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas". Neuro Oncol. 21 (4): 440–450. doi:10.1093/neuonc/noy167. PMC 6422442. PMID 30346624.
  45. Sun ZL, Chan AK, Chen LC, Tang C, Zhang ZY, Ding XJ; et al. (2015). "TERT promoter mutated WHO grades II and III gliomas are located preferentially in the frontal lobe and avoid the midline". Int J Clin Exp Pathol. 8 (9): 11485–94. PMC 4637696. PMID 26617880.
  46. Yang P, Cai J, Yan W, Zhang W, Wang Y, Chen B; et al. (2016). "Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas". Neuro Oncol. 18 (8): 1099–108. doi:10.1093/neuonc/now021. PMC 4933482. PMID 26957363.
  47. Labussière M, Di Stefano AL, Gleize V, Boisselier B, Giry M, Mangesius S; et al. (2014). "TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations". Br J Cancer. 111 (10): 2024–32. doi:10.1038/bjc.2014.538. PMC 4229642. PMID 25314060.
  48. Nencha U, Rahimian A, Giry M, Sechi A, Mokhtari K, Polivka M; et al. (2016). "TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas". J Neurooncol. 126 (3): 441–6. doi:10.1007/s11060-015-1999-3. PMID 26608520.
  49. Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E; et al. (2012). "K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas". Acta Neuropathol. 124 (3): 439–47. doi:10.1007/s00401-012-0998-0. PMC 3422615. PMID 22661320.
  50. Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N; et al. (2019). "H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis". Nat Commun. 10 (1): 1262. doi:10.1038/s41467-019-09140-x. PMC 6425035. PMID 30890717.
  51. Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J; et al. (2012). "Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas". Nat Genet. 44 (3): 251–3. doi:10.1038/ng.1102. PMC 3288377. PMID 22286216.
  52. Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N; et al. (2015). "Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes". Acta Neuropathol. 130 (6): 815–27. doi:10.1007/s00401-015-1478-0. PMC 4654747. PMID 26399631.
  53. Castel D, Grill J, Debily MA (2016). "Histone H3 genotyping refines clinico-radiological diagnostic and prognostic criteria in DIPG". Acta Neuropathol. 131 (5): 795–6. doi:10.1007/s00401-016-1568-7. PMC 4835508. PMID 27038188.
  54. Cordero FJ, Huang Z, Grenier C, He X, Hu G, McLendon RE; et al. (2017). "Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG". Mol Cancer Res. 15 (9): 1243–1254. doi:10.1158/1541-7786.MCR-16-0389. PMC 5581686. PMID 28522693.
  55. Eisenreich S, Abou-El-Ardat K, Szafranski K, Campos Valenzuela JA, Rump A, Nigro JM; et al. (2013). "Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing". PLoS One. 8 (9): e76623. doi:10.1371/journal.pone.0076623. PMC 3785522. PMID 24086756.
  56. Gillet E, Alentorn A, Doukouré B, Mundwiller E, van Thuijl HF, van Thuij H; et al. (2014). "TP53 and p53 statuses and their clinical impact in diffuse low grade gliomas". J Neurooncol. 118 (1): 131–9. doi:10.1007/s11060-014-1407-4. PMID 24590827.
  57. Rodriguez FJ, Schniederjan MJ, Nicolaides T, Tihan T, Burger PC, Perry A (2015). "High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)". Acta Neuropathol. 129 (4): 609–610. doi:10.1007/s00401-015-1400-9. PMC 4696044. PMID 25720745.
  58. 58.0 58.1 Gross appearance of oligodendroglioma. Dr Henry Knipe and Dr Frank Gaillard et al. http://radiopaedia.org/articles/oligodendroglioma
  59. Gross/radiologic findings of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma
  60. 60.0 60.1 Microscopic features of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma
  61. Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 9 October, 2015 Check date values in: |accessdate= (help)
  62. Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
  63. Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D; et al. (2012). "Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity". Acta Neuropathol. 124 (5): 627–41. doi:10.1007/s00401-012-1037-x. PMID 22941225.
  64. Images of microscopic appearance of oligodendroglioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligodendroglioma
  65. Kros JM, Van Eden CG, Stefanko SZ, Waayer-Van Batenburg M, van der Kwast TH (1990). "Prognostic implications of glial fibrillary acidic protein containing cell types in oligodendrogliomas". Cancer. 66 (6): 1204–12. PMID 2205356.
  66. Images of oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma
  67. Smith SF, Simpson JM, Brewer JA, Sekhon LH, Biggs MT, Cook RJ; et al. (2006). "The presence of necrosis and/or microvascular proliferation does not influence survival of patients with anaplastic oligodendroglial tumours: review of 98 patients". J Neurooncol. 80 (1): 75–82. doi:10.1007/s11060-006-9158-5. PMID 16794749.
  68. IHC of oligodendroglioma. Libre Pathology. http://librepathology.org/wiki/index.php/Oligodendroglioma
  69. Hilbig A, Barbosa-Coutinho LM, Netto GC, Bleil CB, Toscani NV (2006). "[Immunohistochemistry in oligodendrogliomas]". Arq Neuropsiquiatr. 64 (1): 67–71. doi:/S0004-282X2006000100014 Check |doi= value (help). PMID 16622556.
  70. Kato Y (2015). "Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas". Brain Tumor Pathol. 32 (1): 3–11. doi:10.1007/s10014-014-0202-4. PMID 25324168.


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