Palmar plantar erythrodysesthesia primary prevention: Difference between revisions

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{{Palmar plantar erythrodysesthesia}}
{{Palmar plantar erythrodysesthesia}}
{{CMG}}
 
{{CMG}}; {{AE}} {{MC}}
 
==Overview==
==Overview==
Avoiding excessive manual work and walking, [[wound]] care to prevent [[infection]], [[limb]] [[elevation]], [[Cold compression therapy|cold compresses]], avoiding extreme [[temperatures]], [[Analgesic|analgesics]], and creams/[[Emollient|emollients]] are suggested to [[Prevention|prevent]], delay onset, and/or decrease the severity of palmar plantar erythrodysesthesia (PPE).
==Primary Prevention==


==Primary prevention==
A number of measures have been suggested to [[Prevention|prevent]], delay onset, and/or decrease the severity of PPE. General measures include:<ref name="pmid2061446">{{cite journal| author=Baack BR, Burgdorf WH| title=Chemotherapy-induced acral erythema. | journal=J Am Acad Dermatol | year= 1991 | volume= 24 | issue= 3 | pages= 457-61 | pmid=2061446 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2061446  }} </ref> <ref name="pmid10071309">{{cite journal| author=Susser WS, Whitaker-Worth DL, Grant-Kels JM| title=Mucocutaneous reactions to chemotherapy. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 3 | pages= 367-98; quiz 399-400 | pmid=10071309 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10071309  }} </ref> <ref name="pmid15341880">{{cite journal| author=Lassere Y, Hoff P| title=Management of hand-foot syndrome in patients treated with capecitabine (Xeloda). | journal=Eur J Oncol Nurs | year= 2004 | volume= 8 Suppl 1 | issue=  | pages= S31-40 | pmid=15341880 | doi=10.1016/j.ejon.2004.06.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15341880  }} </ref> <ref name="pmid12660565">{{cite journal| author=Gerbrecht BM| title=Current Canadian experience with capecitabine: partnering with patients to optimize therapy. | journal=Cancer Nurs | year= 2003 | volume= 26 | issue= 2 | pages= 161-7 | pmid=12660565 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12660565  }} </ref>
The cooling of hands and feet may help prevent PPE (Baack and Burgdorf, 1991; Zimmerman et al, 1995).


* Dr Kuznecovs with his colleagues came to the conclusion that atorvastatin and polyprenol combination can prevent PPE due to capecitabine. https://www.medscape.com/viewarticle/848530
* Avoiding excessive manual work and walking, to [[Prevention|prevent]] excessive pressure or [[friction]] to the [[skin]]
* Application of ointment containing antioxidants with high radical protection factors can effectively prevent the development of PPE.<ref name="pmid23969763">{{cite journal| author=Lademann J, Martschick A, Kluschke F, Richter H, Fluhr JW, Patzelt A et al.| title=Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy. | journal=Skin Pharmacol Physiol | year= 2014 | volume= 27 | issue= 2 | pages= 66-70 | pmid=23969763 | doi=10.1159/000351801 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23969763  }}</ref>
*[[Wound]] care to [[Prevention|prevent]] [[infection]]
* In a randomized control trial in patients that were using pegylated liposomal doxorubicin, it was proven that reduction of dose intensity can effectively prevent PPE. When the dose of PLD is not in excess of 10mg/m(2) weekly, PPE can be easily managed. As the literature support is limited, panel of experts advise patient education and supportive measures for prevention and treatment of PPE.<ref name="pmid18331788">{{cite journal| author=von Moos R, Thuerlimann BJ, Aapro M, Rayson D, Harrold K, Sehouli J et al.| title=Pegylated liposomal doxorubicin-associated hand-foot syndrome: recommendations of an international panel of experts. | journal=Eur J Cancer | year= 2008 | volume= 44 | issue= 6 | pages= 781-90 | pmid=18331788 | doi=10.1016/j.ejca.2008.01.028 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18331788  }}</ref>
*[[Limb]] elevation to reduce [[edema]]
* In another study, a group of patients were given topical ointment with PLD and observed for the development of PPE. Among the patients, 60% regularly applied cream and effectively did not develop PPE. The rest of the 40% of patients interrupted their application of ointment, from which, six developed PPE and thereafter resumed the application of ointment. As a result of restarting application, palmar plantar erythrodysesthesia completely disappeared or was strongly reduced.<ref name="pmid239697632">{{cite journal| author=Lademann J, Martschick A, Kluschke F, Richter H, Fluhr JW, Patzelt A et al.| title=Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy. | journal=Skin Pharmacol Physiol | year= 2014 | volume= 27 | issue= 2 | pages= 66-70 | pmid=23969763 | doi=10.1159/000351801 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23969763  }}</ref>
*[[Cold compression therapy|Cold compresses]]
* Avoiding extreme [[temperatures]]
*[[Analgesic|Analgesics]]
* Creams and [[Emollient|emollients]]


==References==
==References==

Latest revision as of 19:27, 8 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D. [2]

Overview

Avoiding excessive manual work and walking, wound care to prevent infection, limb elevation, cold compresses, avoiding extreme temperatures, analgesics, and creams/emollients are suggested to prevent, delay onset, and/or decrease the severity of palmar plantar erythrodysesthesia (PPE).

Primary Prevention

A number of measures have been suggested to prevent, delay onset, and/or decrease the severity of PPE. General measures include:[1] [2] [3] [4]

References

  1. Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
  2. Susser WS, Whitaker-Worth DL, Grant-Kels JM (1999). "Mucocutaneous reactions to chemotherapy". J Am Acad Dermatol. 40 (3): 367–98, quiz 399-400. PMID 10071309.
  3. Lassere Y, Hoff P (2004). "Management of hand-foot syndrome in patients treated with capecitabine (Xeloda)". Eur J Oncol Nurs. 8 Suppl 1: S31–40. doi:10.1016/j.ejon.2004.06.007. PMID 15341880.
  4. Gerbrecht BM (2003). "Current Canadian experience with capecitabine: partnering with patients to optimize therapy". Cancer Nurs. 26 (2): 161–7. PMID 12660565.