Toxic epidermal necrolysis causes: Difference between revisions

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{{Toxic epidermal necrolysis}}
{{Toxic epidermal necrolysis}}
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==Overview==
==Overview==
Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, [[nonsteroidal anti-inflammatory drugs]], [[allopurinol]], [[antiretroviral drugs]], [[corticosteroids]] and [[anticonvulsant]]s such as [[phenobarbital]], [[phenytoin]], [[carbamazepine]], and [[valproic acid]].  The condition might also result from immunizations,  infection with agents such as ''[[Mycoplasma pneumoniae]]'' or  [[herpes virus]] and [[Organ transplant|transplant]]s of [[bone marrow]] or organs.
Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, [[nonsteroidal anti-inflammatory drugs]], [[allopurinol]], [[antiretroviral drugs]], [[corticosteroids]] and [[anticonvulsant]]s such as [[phenobarbital]], [[phenytoin]], [[carbamazepine]], and [[valproic acid]].  The condition might also result from immunizations,  infection with agents such as ''[[Mycoplasma pneumoniae]]'' or  [[herpes virus]] and [[Organ transplant|transplant]]s of [[bone marrow]] or organs.
==Causes==
==Causes==
===Life-threatening Causes===
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common.
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
*[Cause] is a life-threatening cause of [disease].
===Common Causes===
Common causes of [disease name] may include:
*[Cause1]
*[Cause2]
*[Cause3]


OR
*[Disease name] is caused by an infection with [pathogen name].
*[Pathogen name] is caused by [pathogen name].
===Less Common Causes===
Less common causes of [disease name] include:
*[Cause1]
*[Cause2]
*[Cause3]
===Genetic Causes===
*[Disease name] is caused by a mutation in the [gene name] gene.
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}
===Causes in Alphabetical Order===
Drug Side Effects
Drug Side Effects
* [[Acetaminophen]]
* [[Acetaminophen]]
*[[Amoxycillin]]
* [[Amifostine]]
*[[Cytarabine]]
* [[Amoxycillin]]
* [[Aztreonam]]
* [[Butalbital]]
* [[Cefadroxil]]
* [[Cefaclor]]
* [[Ceftibuten]]
* [[Cefotaxime sodium]]
* [[Cefotetan disodium]]
* [[Ceftazidime]]
* [[Certolizumab pegol]]
* [[Cladribine]]
* [[Clobazam]]
* [[clofarabine]]
*[[Cysteamine]]
* [[Cytarabine]]
* [[Dactinomycin]]
* [[diclofenac (patch)]]
* [[Doripenem]]
* [[Etravirine]]
* [[Flurbiprofen]]
*[[Idelalisib]]
* [[Piperacillin/tazobactam]]
*[[Pralatrexate]]
* [[Lacosamide]]
* [[Rifampin]]
* [[Ritonavir]]
* [[Ibritumomab tiuxetan]]
* [[Isotretinoin]]
* [[Isotretinoin]]
*[[Meropenem]]
* [[Meropenem]]
*[[Terconazole]]
*[[Oxaprozin]]
*[[Sorafenib]]
* [[Terconazole]]
*[[Spironolactone]]
* [[[[Tolmetin]]
*[[Sulfasalazine]]
* [[Piperacillin]]
* [[Sorafenib]]
* [[Spironolactone]]
* [[Sulfasalazine]]
* [[Sulfacetamide]]
* [[Sulfamethoxazole/Trimethoprim (oral)]]
* [[Trovafloxacin mesylate]]
 
* [[Valdecoxib]],


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
[[Category:Dermatology]]
[[Category:Medical emergencies]]
[[Category:Emergency medicine]]
[[Category:Disease]]
[[Category:Needs content]]
[[Category:Needs causes]]


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Latest revision as of 15:57, 15 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, nonsteroidal anti-inflammatory drugs, allopurinol, antiretroviral drugs, corticosteroids and anticonvulsants such as phenobarbital, phenytoin, carbamazepine, and valproic acid. The condition might also result from immunizations, infection with agents such as Mycoplasma pneumoniae or herpes virus and transplants of bone marrow or organs.

Causes

Life-threatening Causes

  • Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
  • Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
  • [Cause] is a life-threatening cause of [disease].

Common Causes

Common causes of [disease name] may include:

  • [Cause1]
  • [Cause2]
  • [Cause3]


OR


  • [Disease name] is caused by an infection with [pathogen name].
  • [Pathogen name] is caused by [pathogen name].

Less Common Causes

Less common causes of [disease name] include:

  • [Cause1]
  • [Cause2]
  • [Cause3]

Genetic Causes

  • [Disease name] is caused by a mutation in the [gene name] gene.

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes


Causes in Alphabetical Order

Drug Side Effects

References

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