VIPoma other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2] Homa Najafi, M.D.[3]
Overview
Other diagnostic studies for VIPoma include immunohistochemical staining test, which demonstrates staining for markers such as chromogranin A, cytokeratin 19, synaptophysin, Ki-67, neuron specific enolase, PGP 9.5.
Other Diagnostic Studies
- Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for:[1]
- Chromogranin A
- Cytokeratin 19 positive stain is an independent marker of aggressive behavior in pancreatic neuroendocrine tumors.
- Synaptophysin
- Ki-67 (indicates the percentage of neoplastic cells immunolabeled for the marker of proliferation Ki67)
- NSE (neuron-specific enolase)
- PGP 9.5 (protein gene product 9.5)
References
- ↑ Chetty R (2008). "An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology". Arch Pathol Lab Med. 132 (8): 1285–9. doi:10.1043/1543-2165(2008)132[1285:AOOPII]2.0.CO;2. PMID 18684027.