Thyroid nodule secondary prevention

Jump to navigation Jump to search

Thyroid nodule Microchapters


Patient Information


Historical Perspective




Differentiating Thyroid nodule from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic study of choice

History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Thyroid nodule secondary prevention On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Thyroid nodule secondary prevention

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Thyroid nodule secondary prevention

CDC on Thyroid nodule secondary prevention

Thyroid nodule secondary prevention in the news

Blogs on Thyroid nodule secondary prevention

Directions to Hospitals Treating Thyroid nodule

Risk calculators and risk factors for Thyroid nodule secondary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]


Secondary prevention of thyroid nodules focuses on prevention of recurrence of nodules. Different prevention strategies may be used depending upon whether the nodule is benign or malignant. In case of a malignant nodule, the major focus is on the prevention of recurrence after removal of a primary nodule. Post-operative periodic monitoring with serum thyroglobulin levels, radioactive iodine scanning, neck ultrasound and thyroid stimulating hormone (TSH) may decrease the chances of recurrence.

Secondary Prevention

Secondary prevention of thyroid nodules focuses on prevention of recurrence of nodules. Different prevention strategies may be used depending upon whether the nodule is benign or malignant:[1][2]

Prevention of benign nodules

Prevention of malignant nodules

Secondary prevention of a thyroid nodule is aimed at the prevention of recurrence after removal of a primary nodule (specially in case of malignant lesions). The following steps outline the secondary prevention of malignant thyroid nodules:

1. Routine screening for disease recurrence

2. Serum TSH goals

  • Maintain TSH levels between:
    • Non-stimulated thyroglobulin < 0.2 ng/ml : TSH should be 0.5-2.0 mU/L
    • Non-stimulated thyroglobulin greater than equal to 0.2 ng/ml: TSH should be 0.1-0.5 mU/L

3. Evaluation of response to therapy

4a. Excellent response to therapy


  1. Snook KL, Stalberg PL, Sidhu SB, Sywak MS, Edhouse P, Delbridge L (2007). "Recurrence after total thyroidectomy for benign multinodular goiter". World J Surg. 31 (3): 593–8, discussion 599–600. doi:10.1007/s00268-006-0135-0. PMID 17308855.
  2. Moalem J, Suh I, Duh QY (2008). "Treatment and prevention of recurrence of multinodular goiter: an evidence-based review of the literature". World J Surg. 32 (7): 1301–12. doi:10.1007/s00268-008-9477-0. PMID 18305998.