Sphingosine kinase 1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
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View/Edit Human

Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.

Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P) SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of Phospholipase D (PLD)

Sphingosine-1-phosphate (S1P) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of S1P by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of S1P and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.

Interactions

SPHK1 has been shown to interact with TRAF2.

Further reading

• Tsukahara T, Mizuno H, Igarashi Y (Mar 2002). "[Molecular diversity of sphingosine kinase]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 47 (4 Suppl): 509–13. PMID 11915350.
• Sudo K, Chinen K, Nakamura Y (Nov 1994). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics. 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S (Jun 2000). "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform". The Journal of Biological Chemistry. 275 (26): 19513–20. doi:10.1074/jbc.M002759200. PMID 10751414.
• Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S (May 2000). "Functional characterization of human sphingosine kinase-1". FEBS Letters. 473 (1): 81–4. doi:10.1016/S0014-5793(00)01510-6. PMID 10802064.
• Melendez AJ, Carlos-Dias E, Gosink M, Allen JM, Takacs L (Jun 2000). "Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution". Gene. 251 (1): 19–26. doi:10.1016/S0378-1119(00)00205-5. PMID 10863092.
• Pitson SM, D'andrea RJ, Vandeleur L, Moretti PA, Xia P, Gamble JR, Vadas MA, Wattenberg BW (Sep 2000). "Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes". The Biochemical Journal. 350 Pt 2 (2): 429–41. doi:10.1042/0264-6021:3500429. PMC 1221270. PMID 10947957.
• Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA (Mar 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological Chemistry. 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. PMC 3234989. PMID 11777919.
• Melendez AJ, Khaw AK (May 2002). "Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells". The Journal of Biological Chemistry. 277 (19): 17255–62. doi:10.1074/jbc.M110944200. PMC 3617247. PMID 11856736.
• Hayashi S, Okada T, Igarashi N, Fujita T, Jahangeer S, Nakamura S (Sep 2002). "Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein". The Journal of Biological Chemistry. 277 (36): 33319–24. doi:10.1074/jbc.M201442200. PMID 12077123.
• Lacaná E, Maceyka M, Milstien S, Spiegel S (Sep 2002). "Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity". The Journal of Biological Chemistry. 277 (36): 32947–53. doi:10.1074/jbc.M202841200. PMID 12080051.
• Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM (Sep 2002). "PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)". The Journal of Biological Chemistry. 277 (38): 35257–62. doi:10.1074/jbc.M203033200. PMID 12124383.
• Pitson SM, Moretti PA, Zebol JR, Zareie R, Derian CK, Darrow AL, Qi J, D'Andrea RJ, Bagley CJ, Vadas MA, Wattenberg BW (Dec 2002). "The nucleotide-binding site of human sphingosine kinase 1". The Journal of Biological Chemistry. 277 (51): 49545–53. doi:10.1074/jbc.M206687200. PMID 12393916.
• Nava VE, Hobson JP, Murthy S, Milstien S, Spiegel S (Nov 2002). "Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells". Experimental Cell Research. 281 (1): 115–27. doi:10.1006/excr.2002.5658. PMID 12441135.
• MacKinnon AC, Buckley A, Chilvers ER, Rossi AG, Haslett C, Sethi T (Dec 2002). "Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents". Journal of Immunology. 169 (11): 6394–400. doi:10.4049/jimmunol.169.11.6394. PMID 12444147.

External links

• Paugh SW, Kapitonov D, Spiegel S (2007-11-08). "Sphingosine kinase 1". UCSD-Nature Molecule Pages. Signaling Gateway: University of California San Diego (UCSD) and Nature Publishing Group. doi:10.1038/mp.a002219.01. Retrieved 2008-09-15.