Serotype

Agglutination of HLA-A3 positive red blood cells (RBCs) with anti-A3 alloreactive antisera containing Anti-A3 IgM

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Overview

For the term's use in bacteriology, see serovar.

Serotype (Allograft)

Transplants between genetically non-identical humans induce the creation of antibodies in the recipient. These non-identical cell-surface receptors between the donor and recipient produce antiserum reactive to the donor proteins. Under selection conditions one or two isoform specificities are obtained. This results in a serotype that is capable of identifying other individuals who have those proteins. This serotyping along with new-PCR based techniques are how tissues for organ-donor programs are characterized. (for more detailed information see Human leukocyte antigens and HLA Serotype tutorial)

Serotypes according the HLA (MHC) locus

HLA	# of	Broad	Split
Locus	Serotypes	Antigens	Antigens
A	25	4	15
B	50	9	24
C*	12	1	2
DR	21	4	8
DQ	8	2	5
DP*
*DP and many Cw require SSP-PCR for typing.

External links

• Molecular Anthropology Yahoo Group
  
• HLA Allele and Haplotype Frequency Database