SPARCL Study
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SPARCL Study On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Objective
To study the effects of statins on incidence of recurrent stroke after a recent episode of stroke or transient ischemic attack
Methods
Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) was a double blinded study with subjects who had at least one episode of stroke in the last one to six months and LDL levels of 100 to 190 mg/dl with no history of coronary artery disease. These patients were randomly assorted to receive either 80 mg of atorvastatin daily or placebo. The primary end point for the study was first fatal or non-fatal stroke.
Results
- During the mean follow up period of 4.9 years, 11.2% of patients from the atorvastatin group and 13.1% of patients from the placebo experienced fatal/non-fatal stroke, with a 5 year absolute risk reduction of 2.2%.
- The 5 year absolute risk reduction in major cardiovascular events was 3.5%.
- The overall mortality rates were similar in both the groups.
Conclusion
Atorvastatin (80 mg daily) reduced the incidence of recurrent stroke and cardiovascular events in patients with a recent episode of stroke or transient ischemic attacks. However, the incidence of hemorrhagic stroke increased in the atorvastatin group.[1]
References
- ↑ Amarenco P, Bogousslavsky J, Callahan A; et al. (2006). "High-dose atorvastatin after stroke or transient ischemic attack". The New England Journal of Medicine. 355 (6): 549–59. doi:10.1056/NEJMoa061894. PMID 16899775. Unknown parameter
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