Psoriasis other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Skin biopsy may be helpful in the diagnosis of psoriasis. Common findings include perivascular and dermal inflammatory cell infiltration, vascular dilation, and absent granular layer.
Other Diagnostic Studies
Skin Biopsy
Skin biopsy may be helpful in the diagnosis of psoriasis. On an hematoxylin and eosin (H&E) stain, the following findings may be observed:[1]
- Perivascular and dermal inflammatory cell infiltration
- Vascular dilation
- Absent granular layer
- Elongation of dermal papillae
- Parakeratosis
- Spongiform pustules of Kogoj (pathognomic of psoriasis)
- Munro's micro abscesses (pathognomic of psoriasis)
- Edema of dermal papillae
- In psoriasis, skin biopsy of the affected area of skin shows that the epidermal/suprapapillary thickness ratio is increased
- Basal cell layer is expanded
References
- ↑ Werner B, Bresch M, Brenner FM, Lima HC (2008). "Comparative study of histopathological and immunohistochemical findings in skin biopsies from patients with psoriasis before and after treatment with acitretin". J. Cutan. Pathol. 35 (3): 302–10. doi:10.1111/j.1600-0560.2007.00800.x. PMID 18251745.