Post-thrombotic syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Causes
Despite ongoing research, the cause of PTS is not entirely clear. Inflammation is thought to play a role [1][2] as well as damage to the venous valves from the thrombus itself. This valvular incompetence combined with persistent venous obstruction from thrombus increases the pressure in veins and capillaries. Venous hypertension induces a rupture of small superficial veins, subcutaneous hemorrhage[3] and an increase of tissue permeability. That is manifested by pain, swelling, discoloration, and even ulceration.[4]
References
- ↑ Shbaklo H, Holcroft CA, Kahn SR. Levels of inflammatory markers and the development of the post-thrombotic syndrome. Thromb Haemost 2009; 101:505-12.
- ↑ Roumen-Klappe EM, Janssen MC, Van Rossum J, Holewijn S, Van Bokhoven MM, Kaasjager K, et al. Inflammation in deep vein thrombosis and the development of post-thrombotic syndrome: a prospective study. J Thromb Haemost 2009;7:582-7.
- ↑ Pirard D., Bellens B., Vereecken P. The post-thrombotic syndrome - a condition to prevent. Dermatology Online Journal 14 (3): 13
- ↑ Vedantham S. Valvular dysfunction and venous obstruction in the post-thrombotic syndrome. Thromb Res 2009; 123 Suppl 4: S62-5.