Myxoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2] Maria Fernanda Villarreal, M.D. [3]


Cardiac myxoma was first described in 1845. In 1951, Prichard described a kind of microscopic endocardial structure of the atrial septum, which was suggested to be associated with cardiac myxoma. Clarence Crafoord, a Swedish cardiovascular surgeon successfully removed a cardiac myxoma for the first time in 1954. Before 1951, cardiac myxoma diagnosis was made only at post-mortem examination.

Historical perspective

  • In 1845, the first description of a left atrial myxoma was reported by King.[1]

Landmark Events in the Development of Treatment Strategies

  • In 1954, Clarence Crafoord (1899 – 1984), a Swedish cardiovascular surgeon, successfully removed a cardiac myxoma for the first time. This case also represents the first extirpation of a cardiac tumor on cardiopulmonary support.[7][8]


  1. King TW. On simple vascular growths in the left auricle of the heart. Lancet 1845; 2:428-9
  2. Amano J, Kono T, Wada Y, Zhang T, Koide N, Fujimori M, Ito K (2003). "Cardiac myxoma: its origin and tumor characteristics". Ann Thorac Cardiovasc Surg. 9 (4): 215–21. PMID 13129418.
  3. Guhathakurta S, Riordan JP (2000). "Surgical treatment of right atrial myxoma". Tex Heart Inst J. 27 (1): 61–3. PMC 101023. PMID 10830633.
  4. Pinede L, Duhaut P, Loire R (2001). "Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases". Medicine (Baltimore). 80 (3): 159–72. PMID 11388092.
  5. Carney JA, Hruska LS, Beauchamp GD, Gordon H (1986). "Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity". Mayo Clin. Proc. 61 (3): 165–72. PMID 3945116.
  6. Mabuchi T, Shimizu M, Ino H, Yamguchi M, Terai H, Fujino N, Nagata M, Sakata K, Inoue M, Yoneda T, Mabuchi H (2005). "PRKAR1A gene mutation in patients with cardiac myxoma". Int. J. Cardiol. 102 (2): 273–7. doi:10.1016/j.ijcard.2004.05.053. PMID 15982496.
  7. Chitwood WR (1992). "Clarence Crafoord and the first successful resection of a cardiac myxoma". Ann. Thorac. Surg. 54 (5): 997–8. PMID 1417305.
  8. Chitwood WR (November 1992). "Clarence Crafoord and the first successful resection of a cardiac myxoma". Ann. Thorac. Surg. 54 (5): 997–8. doi:10.1016/0003-4975(92)90676-u. PMID 1417305.

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