Multiple sclerosis primary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.


Effective measures for the primary prevention of multiple sclerosis include: Vitamin D supplement, smoking cessation, and early exposure to infections.

Primary Prevention

Effective measures for the primary prevention of multiple sclerosis include:

  • Smoking cessation: Smoking cessation proved to be beneficial in reducing the incidence of MS disease.[4]


  1. Hollis BW (February 2005). "Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D". J. Nutr. 135 (2): 317–22. PMID 15671234.
  2. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R (July 2005). "Estimates of optimal vitamin D status". Osteoporos Int. 16 (7): 713–6. doi:10.1007/s00198-005-1867-7. PMID 15776217.
  3. Vieth R (May 1999). "Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety". Am. J. Clin. Nutr. 69 (5): 842–56. PMID 10232622.
  4. Hernán MA, Olek MJ, Ascherio A (July 2001). "Cigarette smoking and incidence of multiple sclerosis". Am. J. Epidemiol. 154 (1): 69–74. PMID 11427406.
  5. Warner HB, Carp RI (December 1981). "Multiple sclerosis and Epstein-Barr virus". Lancet. 2 (8258): 1290. PMID 6118702.
  6. Bach JF (September 2002). "The effect of infections on susceptibility to autoimmune and allergic diseases". N. Engl. J. Med. 347 (12): 911–20. doi:10.1056/NEJMra020100. PMID 12239261.

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