Microscopic polyangiitis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
There are no known direct causes for Microscopic polyangiitis. Microscopic polyangiitis can affect individuals from all ethnicities and of any age group.Vasculitis is a common term that refers to inflammation of the blood vessels in the body. When the inflammation progress it lead to weakening and stretch of the blood vessels and forms a an aneurysm.
Causes
Common Causes
There are no known direct common causes for Microscopic polyangiitis. However microscopic polyangiitis may be caused by:[1][2][3]
- Autoimmune mechanism
- Infections
- Drugs
Less Common Causes
- Silica exposure
- Malignancy
Genetic Causes
- HLA-DRB1*09:01-DQB1*03:03 haplotype genes shows a significant increase in the association with Microscopic polyangiitis.[4]
- These haplotypes are mostly found in Japanese population.[5]
- Activation of NK/ T cells may also lead to predisposition to Microscopic polyangiitis.[6][7]
References
- ↑ Kallenberg CG, Rarok A, Stegeman CA, Limburg PC (February 2002). "New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis". Autoimmun Rev. 1 (1–2): 61–6. PMID 12849060.
- ↑ Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ (March 2007). "Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study". Clin J Am Soc Nephrol. 2 (2): 290–9. doi:10.2215/CJN.03501006. PMC 4049534. PMID 17699427.
- ↑ Tsuchiya N (2012). "Genetics of microscopic polyangiitis in the Japanese population". Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
- ↑ Tsuchiya N (2012). "Genetics of microscopic polyangiitis in the Japanese population". Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
- ↑ Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (January 2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese". Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405.
- ↑ Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M (February 2005). "Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals". Cancer Immunol. Immunother. 54 (2): 172–8. doi:10.1007/s00262-004-0575-z. PMID 15248031.
- ↑ Miyashita R, Tsuchiya N, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (March 2006). "Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis". Arthritis Rheum. 54 (3): 992–7. doi:10.1002/art.21653. PMID 16508981.