Mantle cell lymphoma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing and FISH.

Laboratory tests

Laboratory tests for mantle cell lymphoma include:

• Complete blood count (CBC) with differential count

• Pancytopenia or a leukemic presentation with extensive leukocytosis.

• Comprehensive metabolic panel
• LDH levels: Normal range is 100–190 U/L
• Hepatitis B testing if treatment with rituximab is planned
• Uric acid levels: Normal range is 2.4-6.0 mg/dL in females and 3.4-7.0 mg/dL in males.
• Beta-2-microglobulin: Normal range is 0-3 µg/mL.
• Pregnancy testing in woman of child-bearing age
• Flow cytometry
• Immunohistochemistry

• CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
• Overexpression of Cyclin D1
• SOX11 expression

• Genetic testing

• Translocation t(11;14)(q13;q32) in virtually all cases
• Mutation or deletions of ATM gene

• FISH (fluorescence in situ hybridization):
  • FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients.