Langerhans cell histiocytosis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Common symptoms of Langerhans cell histiocytosis include bone pain, rash, fever, and failure to thrive.[1][2][3]

History

  • When evaluating a patient for Langerhans cell histiocytosis, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:[3]
    • Review family history for members with positive history of the disease
    • Growth velocity chart
    • Any history of excessive thirst and urination

Symptoms

  • Common symptoms of Langerhans cell histiocytosis among children include:[1][2][3]
  • Common symptoms of Langerhans cell histiocytosis among adults include: [4][5][6][7]

References

  1. 1.0 1.1 Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016
  2. 2.0 2.1 Langerhans cell histiocytosis. Radiopeadia (2015) http://radiopaedia.org/articles/langerhans-cell-histiocytosis Accessed on February, 3 2016
  3. 3.0 3.1 3.2 Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version. National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016
  4. Elena Gkrouzman, Rene H. Cuadra & Jason Jacob (2015). "Langerhans Cell Histiocytosis of the Bone Presenting as Back Pain: An Unusual Diagnosis for a Common Complaint". Connecticut medicine. 79 (7): 409–414. PMID 26411178. Unknown parameter |month= ignored (help)
  5. Hiroyuki Tsuchie, Kyoji Okada, Hiroyuki Nagasawa, Michihiro Yano, Hiroshi Nanjyo & Yoichi Shimada (2009). "Langerhans cell histiocytosis of the sternum". Upsala journal of medical sciences. 114 (2): 121–125. doi:10.1080/03009730802642360. PMID 19396700.
  6. Koray Aydogdu, Ersin Gunay, Gokturk Findik, Sibel Gunay, Yetkin Agackiran, Sadi Kaya, Nurettin Karaoglanoglu & Irfan Tastepe (2013). "Pulmonary Langerhans cell histiocytosis; characteristics of 11 cases". Tuberkuloz ve toraks. 61 (4): 333–341. PMID 24506750.
  7. A. Artigues Barcelo, P. Guiscafre Fontirroig, P. de Miguel Sebastian, R. M. Salgado & M. T. Albiol Varella (2005). "[Fever and hyperprolactinaemia as the onset of Langerhans cell histiocytosis]". Anales de medicina interna (Madrid, Spain : 1984). 22 (11): 535–537. PMID 16454588. Unknown parameter |month= ignored (help)


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