Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1Bgene.[1][2]
Function
LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.[3]
References
↑Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res. 60 (7): 1961–7. PMID10766186.
↑Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID11384978.
Further reading
Liu CX, Musco S, Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics. 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID11031110.
Langbein S, Szakacs O, Wilhelm M, et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer". Lab. Invest. 82 (5): 639–43. doi:10.1038/labinvest.3780458. PMID12004004.
Li Y, Knisely JM, Lu W, et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID12194987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Cam JA, Zerbinatti CV, Knisely JM, et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID15126508.
Tanaga K, Bujo H, Zhu Y, et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID15166012.
Sonoda I, Imoto I, Inoue J, et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID15172977.
Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID15963947.
Pastrana DV, Hanson AJ, Knisely J, et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin". Biochim. Biophys. Acta. 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID16095885.
Nakagawa T, Pimkhaokham A, Suzuki E, et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMID16918994.
Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID17227771.
