Incidentaloma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Most adrenocortical carcinomas are sporadic, but some occur as a component of hereditary cancer syndromes such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and Multiple endocrine neoplasia type 1(MEN1).
Risk Factors
Most adrenocortical carcinomas are sporadic, but some occur as a component of hereditary cancer syndromes.[1][2]
- Hereditary cancer syndromes:
- Li-Fraumeni syndrome (associated with inactivating mutations of the TP53 tumor suppressor gene on chromosome 17p):
- Breast cancer
- Soft tissue and bone sarcoma
- Brain tumors
- Beckwith-Wiedemann syndrome (associated with abnormalities in 11p15):
- Multiple endocrine neoplasia type 1 (MEN1) (associated with inactivating mutations of the MEN1 gene on chromosome 11q):
- Li-Fraumeni syndrome (associated with inactivating mutations of the TP53 tumor suppressor gene on chromosome 17p):
References
- ↑ Sidhu S, Sywak M, Robinson B, Delbridge L (2004). "Adrenocortical cancer: recent clinical and molecular advances". Curr Opin Oncol. 16 (1): 13–8. PMID 14685087.
- ↑ Lynch HT, Radford B, Lynch JF (1990). "SBLA syndrome revisited". Oncology. 47 (1): 75–9. PMID 2300390.