Hypertriglyceridemia omega-3 fatty acids

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]


Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].

Trial Supportive Data

Study name Source & year Study question Study Design Study Population Time period Intervention Results Conclusions
Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia [4] Heart, 2001 To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia Double blinded randomized controlled trial 59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l 1 year Omacor (84% omega-3 fatty acid) 2 g BD or placebo
  • Decrease in serum triglycerides by 20-30% (p<0.005)
  • Decrease in very low-density lipoprotein (VLDL) cholesterol by 30-40% (p<0.005)


Researchers say diets rich in Omega-3 fatty acids can help people with heart disease live longer, but why these oils are so beneficial remains unclear. A new study looks at how higher fish oil levels in the blood may protect the caps on chromosomes, which help measure biological aging

External Links



  1. "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
  2. Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
  3. "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
  4. Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.

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